Glocerin
Glocerin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Glocerin is a brand name. Its generic name is Diacerein.
What is Glocerin?
Glocerin is an anti-inflammatory drug and is used as a disease-modifying anti-rheumatic drug (DMARD). Glocerin is an oral therapy approved for symptomatic treatment of osteoarthritis.
Uses for Glocerin
Glocerin is indicated for the symptomatic treatment of mild to moderate active osteoarthritis of the hip and knee. The drug is especially useful in improving mobility and reducing pain in those suffering from osteoarthritis. It may also have beneficial effects with regards to slowing down the progression of the disease.
Mechanism of Action
Glocerin works by inhibiting the release of various cytokines (chemicals released by cells and tissues) that promote inflammation and contribute to OA symptoms. It works by blocking the enzymes responsible for inflammation and by stimulating the endogenous Joint protective substances, like proteoglycans and chondroitin sulfate.The drug also stimulates the synthesis of cartilage components, like collagen and hyaluronic acid.
How Long Does It Take to Work?
Glocerin is slow acting and it usually takes up to six weeks for the drug to have a maximum effect. However, it can take up to one year to feel the full effects of the drug. The effects are also more gradual than with nonsteroidal anti-inflammatory drugs (NSAIDs).
Absorption
Glocerin is highly absorbable by the gastrointestinal tract, and the bioavailability of the drug is greater than 80%.
Route of Elimination
Glocerin is mainly eliminated by the kidney. It is metabolized in the liver into smaller metabolites that are later excreted in the urine.
Dosage
Glocerin should be taken twice daily, before meals, with a full glass of water. The usual dosage is 1-2 capsules/tablets each time, taken orally. A lower dosage may be recommended by a doctor depending on response and side effects. The dosage may be increased gradually, if necessary. The maximum recommended daily dosage of Glocerin is 2 capsules twice a day (4 capsules/day).
Administration
Glocerin can be taken with or without food. It is advised that Glocerin should be taken with a full glass of water. It is also important to take the medication on a regular basis in order to gain maximum benefit.
Side Effects
The most common side effects of Glocerin include nausea, vomiting, stomach pain, bloating, gas, constipation, and diarrhea. Less common side effects may include headache, drowsiness, allergies, rash, and dizziness. In rare cases, Glocerin may cause kidney problems.
Toxicity
The estimated acute lethal dose of Glocerin in humans is 400-500 mg/kg. In cases of overdose, supportive measures should be taken and gastric lavage may be necessary.
Precaution
Patients should avoid taking Glocerin with other medications as this may increase the risk of side effects. It is advised to consult a doctor before taking Glocerin if the patient is taking any other medication or has any known allergies.
Interaction
Glocerin can interact with anticoagulants (e.g warfarin), as well as other medications such as aspirin and NSAIDS, decreasing their efficacy. Patients should inform their doctor about any other medications they are taking before taking Glocerin.
Disease Interactions
Glocerin may worsen kidney and liver diseases, and patients with pre-existing kidney or liver diseases should take extra precaution. Glocerin may also increase the risk of bleeding in people with clotting disorders.
Drug Interaction
Glocerin can interact with certain drugs, such as warfarin, anticoagulants, aspirin and NSAIDs. Patients should inform their doctor of any other medications they are taking before starting on Glocerin.
Food Interactions
Glocerin should be taken with a full glass of water and should not be taken with food. If patients experience nausea or upset stomachs after taking the drug, they should try taking it with food.
Pregnancy Use
Glocerin should not be used by pregnant women. Glocerin may cause harm to an unborn baby. Women of childbearing age should use effective birth control methods while taking the drug.
Lactation Use
It is unknown whether Glocerin passes into breast milk, or if it could harm a nursing infant. Women should not use Glocerin if they are breast feeding.
Acute Overdose
In case of an overdose, seek immediate medical attention. Overdose symptoms may include nausea, vomiting, stomach pain and diarrhea.
Contraindication
Glocerin is contraindicated in patients with known hypersensitivity to the drug, or patients with pre-existing gastrointestinal disorders such as ulcers, or in patients with impaired renal function.
Use Direction
Patients should take Glocerin exactly as prescribed by their doctor. Do not take more or less of the medication than prescribed. The usual dosage is 1-2 capsules/tablets each time, taken orally, with or without food, twice daily before meals with a full glass of water.
Storage Condition
Glocerin should be stored at room temperature, away from light and moisture, and should also be kept away from children. Discard any expired drug.
Volume of Distribution
The volume of distribution of diacerein in humans is 0.49 L/kg.
Half-Life
The half-life of diacerein is 3-8 hours in humans.
Clearance
The clearance of diacerein from the body is 3.7 mL/min/kg in humans.
Here you find in details version of Glocerin
Some Frequently Asked Questions About Glocerin
What is Glocerin?
Glocerin is an active pharmaceutical ingredient used to treat pain, inflammation, and stiffness related to osteoarthritis. It is a type of glucosamine which is a naturally occurring glucose-containing compound.
How does Glocerin work?
Glocerin works by blocking the release of an important inflammatory chemical known as interleukin-1 from the cells in the joints. By blocking this action, Glocerin helps reduce the inflammation and pain associated with osteoarthritis.
What are the benefits of taking Glocerin?
Glocerin has been shown to provide relief from the pain, inflammation, and stiffness associated with osteoarthritis. It can also help reduce joint deterioration and improve mobility and function.
How should I take Glocerin?
Glocerin should be taken orally, with food, usually once daily. Your doctor will provide you with the correct dosage and treatment plan.
Are there any side effects associated with taking Glocerin?
Yes, there are some possible side effects associated with taking Glocerin, including nausea, upset stomach, and diarrhea. If these persist or worsen, contact your doctor immediately.
Who should not use Glocerin?
Glocerin should not be used by pregnant or breastfeeding women, children, or those with a known hypersensitivity to the drug or any of its ingredients.
What are the drug interactions associated with Glocerin?
Glocerin may interact with other medications, including anti-inflammatory drugs, corticosteroids, immunosuppressants, nonsteroidal anti-inflammatory drugs, and probenecid. Talk to your doctor about any possible drug interactions before taking Glocerin.
Can I take Glocerin with alcohol?
No, Glocerin should not be taken with alcohol.
Are there any special precautions I should take when taking Glocerin?
Yes, you should not take Glocerin if you are allergic to any of its components. Also, tell your doctor if you have ever had any kidney or liver problems before taking Glocerin.
What should I avoid while taking Glocerin?
You should avoid taking any other medications that have not been approved by your doctor while taking Glocerin. It is also important to avoid alcohol, as it can make the side effects of Glocerin worse.
How long will it take for Glocerin to work?
The effects of Glocerin can take several weeks to become fully apparent. It is important to take the medication as directed and to continue taking it even if you do not see immediate relief.
Is it safe to take Glocerin long-term?
Yes, it is generally safe to take Glocerin long-term, as long as it is taken as directed. However, it is important to discuss any long-term use with your doctor.
What happens if I miss a dose of Glocerin?
If you miss a dose of Glocerin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the usual time. Do not double up on doses or take it more frequently than prescribed.
Can I take Glocerin with other pain medications?
Glocerin should not be taken with other pain medications without the approval of your doctor. Some other medications may interact with Glocerin and could cause serious side effects.
What is the recommended dosage for Glocerin?
The recommended dosage of Glocerin depends on your age, weight, and medical condition. Your doctor will provide you with the appropriate dosage.
What should I do if I experience severe side effects with Glocerin?
If you experience any severe side effects while taking Glocerin, contact your doctor right away. In some cases, these side effects may indicate a more serious underlying problem. Do not stop taking Glocerin without speaking to your doctor first.
Are there any natural alternatives to Glocerin?
Yes, there are some natural alternatives to Glocerin such as fish oil, curcumin, and boswellia. These can help reduce inflammation, but should not be taken in place of a doctor-prescribed medication such as Glocerin.
Are there any over-the-counter medications that interact with Glocerin?
Yes, there are some over-the-counter medications that can interact with Glocerin including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and corticosteroids. It is important to discuss any medications you are taking with your doctor to avoid potential drug interactions.
Is Glocerin addictive?
No, Glocerin is not addictive. It is important to take it as directed and not to take more than the prescribed dosage.
Can Glocerin be used to treat other conditions?
No, Glocerin is only approved for use in treating the pain, inflammation, and stiffness related to osteoarthritis. It should not be used for any other purpose without the approval of your doctor.
Can Glocerin be used in combination with other medications?
Yes, Glocerin can be used in combination with other medications as long as they have been approved by your doctor and do not clash with other drugs you are taking.
What are the common side effects of taking Glocerin?
The common side effects of taking Glocerin include nausea, diarrhea, and stomach upset. Less common side effects may include dizziness, rash, headache, and fatigue.
Does Glocerin increase the risk of bleeding or blood clotting?
Yes, Glocerin may increase the risk of bleeding or blood clotting, so it should be used with caution in people with any history of bleeding or coagulation disorders.
What are the possible drug interactions associated with Glocerin?
Glocerin may interact with other medications, including anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs, corticosteroids, immunosuppressants, and probenecid. Talk to your doctor about any possible drug interactions before taking Glocerin.
Can Glocerin be used in children?
No, Glocerin should not be used by children under 18 years of age without the approval of a doctor.
Can Glocerin be used during pregnancy?
No, Glocerin should not be used during pregnancy without the approval of a doctor. It is advised not to take any medication during pregnancy unless it is necessary.
Can Glocerin be used if I have liver problems?
No, Glocerin should not be taken if you have any known liver problems. Speak to your doctor if you have any questions before taking Glocerin.
Can Glocerin cause allergic reactions?
Yes, Glocerin can cause allergic reactions in some people. If you experience any allergic reactions, such as rash, itching, or swelling, contact your doctor immediately.
What is the shelf life of Glocerin?
The shelf life of Glocerin is typically two to three years when stored at room temperature. It is important to check the expiration date before using Glocerin.
Can I take Glocerin if I have kidney problems?
No, you should not take Glocerin if you have any known kidney problems, as it could worsen existing kidney issues. Speak to your doctor if you have any questions before taking Glocerin.
Can Glocerin cause dizziness?
Yes, Glocerin can cause dizziness in some people. If you experience this side effect, contact your doctor immediately.
Do I need to take a break from taking Glocerin?
No, you do not need to take a break from taking Glocerin. However, it is important to take it as directed and to speak with your doctor about any long-term use.
Can Glocerin cause stomach upset?
Yes, Glocerin can cause stomach upset in some people. If this side effect occurs, it is important to contact your doctor immediately.
Is there a generic version of Glocerin available?
Yes, there is a generic version of Glocerin available. Speak to your doctor about generic options before taking Glocerin.
Can Glocerin cause weight gain?
No, Glocerin is not known to cause weight gain. However, it is important to speak to your doctor if you notice any changes in your weight while taking Glocerin.
Can Glocerin be used to treat gout?
No, Glocerin should not be used for gout as it has not been approved for this purpose. Speak to your doctor about treatment options for gout.
Can Glocerin be taken with food?
Yes, Glocerin should ideally be taken with food to help promote absorption. However, it is important to check with your doctor for specific instructions.
Can Glocerin be taken long-term?
Yes, Glocerin can be taken long-term as long as it is taken as directed. However, it is important to discuss any long-term use with your doctor.
Can Glocerin be taken with other arthritis medications?
Yes, Glocerin can be taken with other arthritis medications as long as they do not interact with each other. It is important to talk to your doctor before taking any other medications alongside Glocerin.
Can Glocerin be used to treat rheumatoid arthritis?
Yes, Glocerin has been shown to be effective in treating the pain, inflammation, and stiffness associated with rheumatoid arthritis. However, it is important to talk to your doctor about other treatment options before taking Glocerin.
Is Glocerin a steroid?
No, Glocerin is not a steroid. It is an active pharmaceutical ingredient commonly used to treat the symptoms of osteoarthritis.