G Cyte

G Cyte Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? G Cyte is a brand name. Its generic name is Filgrastim.

G Cyte

G Cyte is a biosynthetic form of human granulocyte colony-stimulating factor (G-CSF). It is used to treat a variety of chronic and acute hematologic conditions, including malignancies, myelodysplastic syndromes, and immunodeficiencies. In malignancies, it is used to increase blood cell counts in patients undergoing chemotherapy and to prevent neutropenia (low levels of neutrophils). G Cyte is also used to increase the number of stem cells collected from the patient's bone marrow for autologous transplantation.

Uses

G Cyte is used to treat neutropenia caused by a variety of conditions, including chemotherapy, radiation therapy, bone marrow transplantation, and some immunologic disorders. It is also used to increase the number of stem cells collected from the bone marrow for autologous transplantation, and to reduce the risk of infection in patients with HIV/AIDS.

Mechanism of Action

G Cyte stimulates the production of neutrophils (white blood cells) in the bone marrow. It binds to the membrane-bound receptor G-CSFR, which activates the JAK/STAT pathway to induce the production of neutrophils. It also promotes the release of neutrophils from the bone marrow into the bloodstream.

How Long Does It Take to Work?

The effects of filgrastim can be seen within 24-48 hours, but it can take up to 2 weeks for the full effects of the drug to be seen. The peak effects of the drug occur 1-2 days after administration.

Absorption

G Cyte is almost completely absorbed after subcutaneous or intramuscular administration. Peak concentrations are reached in 2-4 hours.

Route of Elimination

G Cyte is primarily eliminated by the kidneys. Approximately 70-80% of the drug is excreted unchanged in the urine.

Dosage

The recommended dosage of filgrastim is 5 to 10 mcg per kilogram of body weight administered once a day. The dose can be adjusted up to a maximum of 30 mcg per kilogram depending on the patient’s response. The dosage should be given 1-2 days before chemotherapy or radiation therapy and continued until the patient’s blood cell count returns to normal.

Administration

G Cyte can be administered by subcutaneous or intramuscular injection. The injection should be given in the upper arm, thigh, abdomen, or buttocks.

Side Effect

Common side effects of filgrastim include nausea, vomiting, bone pain, headache, muscle pain, and fatigue. Rare but serious side effects include bone marrow suppression, allergic reactions, and severe respiratory disorders.

Toxicity

G Cyte is not known to be toxic, however long-term use of high doses of the drug can lead to bone marrow suppression.

Precaution

G Cyte should be used with caution in patients with pre-existing hematologic disorders or in those with an increased risk of bleeding. It should not be used in patients with genetic defects in the interleukin-3 (IL-3) receptor alpha chain, and it should be used with caution in patients with renal impairment.

Interaction

There are no known drug or disease interactions with filgrastim.

Food Interactions

No food interactions with filgrastim are known.

Pregnancy Use

G Cyte should be used during pregnancy only if absolutely necessary and only under the supervision of a healthcare provider.

Lactation Use

G Cyte is not known to be excreted in breast milk and should not affect the nursing infant.

Acute Overdose

There is no specific antidote for an overdose of filgrastim and treatment is symptomatic and supportive. Intravenous fluids and electrolyte replacement may be necessary.

Contraindication

G Cyte is contraindicated in patients with a known hypersensitivity to recombinant G-CSF or any of the components of the product.

Use Direction

G Cyte should be administered by subcutaneous or intramuscular injection. The injection should be given in the upper arm, thigh, abdomen, or buttocks.

Storage Condition

G Cyte should be stored at temperatures between 20° and 25°C. It should be protected from light and kept away from heat and moisture.

Volume of Distribution

After intravenous administration, the volume of distribution of filgrastim is approximately 3.7 liters per kilogram.

Half Life

The elimination half-life of filgrastim is approximately 3 hours.

Clearance

The total body clearance of filgrastim is approximately 26 liters per hour per kilogram.

Here you find in details version of G Cyte

Some Frequently Asked Questions About G Cyte

What is G Cyte?

G Cyte is an injectable biologic prescription medicine used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease.

What is the active ingredient in G Cyte?

The active ingredient in G Cyte is recombinant human granulocyte-colony stimulating factor, which is a recombinant DNA-derived human protein.

How does G Cyte work?

G Cyte helps the body to produce more neutrophils, which are a type of white blood cell that fights infection. This helps to reduce the chance of infection in people with cancer or Chronic Granulomatous Disease (CGD).

What are some of the side effects of G Cyte?

The most common side effects of G Cyte include bone pain, injection site reactions, headache, and fatigue. Tell your doctor if you have any side effects.

How is G Cyte given?

G Cyte is given as a single injection under your skin. Your doctor will advise when and how to use it.

Who should not take G Cyte?

Do not take G Cyte if you are allergic to it, had a severe allergic or hypersensitivity reaction after receiving filgrastim in the past, or suffered from a splenic rupture before.

What is G Cyte used for?

G Cyte is used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

What should I tell my healthcare provider before taking G Cyte?

Tell your healthcare provider if you are pregnant, breastfeeding, have liver or kidney disease, or have any allergies.

What if I forget a dose of G Cyte?

If you miss a dose of G Cyte, contact your healthcare provider for advice on when to take your next dose.

Can G Cyte be used during pregnancy?

G Cyte should not be used during pregnancy unless clearly necessary. Talk to your doctor about any potential risks to your pregnancy.

Who should not take G Cyte?

Do not take G Cyte if you are allergic to it, had a severe allergic or hypersensitivity reaction after receiving filgrastim in the past, or suffered from a splenic rupture before.

What is the recommended dose of G Cyte?

The recommended dose of G Cyte is determined by your healthcare provider and depends on your age, body weight, and medical condition.

Are there any drug interactions with G Cyte?

Yes, G Cyte may interact with other medications such as anticoagulants, corticosteroids, and other immunosuppressants. Talk to your doctor or pharmacist about any potential drug interactions.

Does G Cyte have any side effects?

The most common side effects of G Cyte include bone pain, injection site reactions, headache, and fatigue. Tell your doctor if you have any side effects.

Can children take G Cyte?

Yes, G Cyte is approved for use in children two years of age and older. Talk to your doctor to determine if G Cyte is right for your child.

What should I do if I experience any side effects from G Cyte?

If you experience any side effects from G Cyte, contact your doctor or healthcare provider immediately.

Can I take G Cyte if I'm breastfeeding?

G Cyte should not be taken while breastfeeding due to the risk of side effects in the infant. Talk to your doctor for more information.

Can G Cyte be used for chronic granulomatous disease?

Yes, G Cyte is used to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

Are there any risks associated with taking G Cyte?

Yes, there is a risk of serious side effects associated with taking G Cyte, such as splenic rupture. Talk to your doctor or healthcare provider for more information.

What should I do if I miss a dose of G Cyte?

If you miss a dose of G Cyte, contact your healthcare provider for advice on when to take your next dose.

What should I avoid while taking G Cyte?

You should avoid activities that may put you at risk of infection, such as contact sports or swimming in public pools.

Can I take other medications with G Cyte?

You should tell your healthcare provider about all the medications you are taking, including prescription and non-prescription drugs, vitamins, and herbal supplements, as they may interact with G Cyte.

Can I drive or operate machinery while taking G Cyte?

You should avoid driving or operating machinery while taking G Cyte, as it may cause side effects such as dizziness or fatigue.

What should I do if I experience any signs of infection while taking G Cyte?

If you experience any signs of infection while taking G Cyte, such as fever, chills, or sore throat, contact your doctor or healthcare provider immediately.

How long should I take G Cyte?

The length of treatment with G Cyte will depend on your individual needs and should be determined by your doctor.

Are there alternative treatments for reducing infection risk?

Yes, other treatments such as antibiotics or immune-modulating drugs may be used to reduce infection risk.

How should I store G Cyte?

G Cyte should be stored in a refrigerator at 2°C – 8°C (36°F – 46°F). Keep out of reach of children and away from heat and light.

Can I take G Cyte if I have liver or kidney disease?

Talk to your doctor before taking G Cyte if you have liver or kidney disease. Your doctor may adjust your dose or recommend an alternative treatment.

Will G Cyte affect my fertility?

G Cyte has been known to affect fertility in animal studies. Talk to your doctor if you are concerned about a possible effect on your fertility.

Should I avoid certain activities while taking G Cyte?

You should avoid contact sports and activities that may put you at risk of infection while taking G Cyte.

What other drugs are similar to G Cyte?

Other drugs similar to G Cyte include pegfilgrastim and biosimilars. Talk to your doctor or pharmacist about the differences between these drugs.

Can G Cyte be used to treat cancer?

No, G Cyte is used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

What if I overdose on G Cyte?

If you have overdosed on G Cyte, contact your healthcare provider or poison control center right away.

Are there any food restrictions while taking G Cyte?

No, there are no food restrictions while taking G Cyte.

How long does G Cyte stay in the body?

G Cyte typically stays in the body for about 24 hours.

Is there a generic version of G Cyte available?

Yes, there is a generic version of G Cyte available.

What happens if I take too much G Cyte?

If you take too much G Cyte, contact your doctor or healthcare provider right away.

Can G Cyte be used to reduce the risk of infection in the elderly?

Yes, G Cyte can be used to reduce the risk of infection in the elderly.

Can I use G Cyte if I'm allergic to other drugs?

You should tell your healthcare provider about any allergies you may have in order to determine if G Cyte is safe for you to use.

Can I drink alcohol while taking G Cyte?

It is best to avoid drinking alcohol while taking G Cyte. Talk to your doctor for more information.

Can G Cyte cause weight gain?

Weight gain has been reported in people taking G Cyte; however, it is not known if this is due to the drug itself or to other factors such as diet or lifestyle changes.

What should I do if I have an allergic reaction to G Cyte?

If you have an allergic reaction to G Cyte, stop taking it and contact your doctor or healthcare provider right away.

Is G Cyte covered by insurance?

G Cyte may be covered by some insurance plans. Check with your insurance provider to see if G Cyte is covered.

When will I start to notice an effect from taking G Cyte?

The effect of G Cyte will depend on your individual needs and should be determined by your doctor. Talk to your doctor for more information.