Flonasin

Flonasin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Flonasin is a brand name. Its generic name is Azelastine + Fluticasone Propionate.

Flonasin Introduction

Flonasin is a fixed-dose combination medication used to treat allergic rhinitis (hay fever). The active ingredients of the combination medication are azelastine hydrochloride, an antihistamine, and fluticasone propionate, a glucocorticosteroid. Flonasin is a combination medication used to reduce the symptoms of hay fever including sneezing, itching, runny nose, and congestion.

Uses for Flonasin

Flonasin is used to relieve the symptoms of allergic rhinitis, e.g. sneezing, itching, runny nose, and congestion. It is also used to treat nasal polyps.

Mechanism of Action

Flonasin works by blocking the action of certain chemical messengers that are responsible for allergic reactions in the body. Azelastine is an antihistamine and works by blocking histamine, a chemical messenger that is responsible for allergic symptoms such as runny nose, sneezing, itching, and congestion. Fluticasone propionate is a glucocorticosteroid and works by suppressing inflammation and decreasing the activity of the immune system.

How Long Does It Take to Work?

Flonasin starts to work immediately after you take it. Generally, it takes about 7 to 10 days for the drug to reach its full effect.

Absorption

Flonasin is rapidly absorbed by the body after oral administration.

Route of Elimination

Flonasin is eliminated primarily via the urine and, to a lesser extent, the feces.

Dosage

The recommended dose of Flonasin depends on the patient’s age, weight, and condition. For adults and adolescents 12 years or older, the usual dose is one spray, 0.156 mg azelastine and 50 mcg fluticasone propionate, in each nostril twice daily. The dose for children 6 to 11 years of age is one spray, 0.156 mg of azelastine and 25 mcg of fluticasone propionate, in each nostril twice daily.

Administration

Flonasin should be administered by the intranasal route only. This medication should be sprayed into the external nares (nostrils).

Side Effects

Common side effects of Flonasin include headache, nosebleed, sore throat, cough, nasal discomfort, nose burning/stinging, joint/muscle pain, change in taste, coughing up blood, and difficulty sleeping.

Toxicity

The toxicity of Flonasin is low. When used as directed, it is not expected to cause serious or life-threatening side effects.

Precaution

Flonasin should be used with caution in people with a known sensitivity or allergy to azelastine, fluticasone, or any other ingredients found in this medication. It should also be used cautiously in people with active or quiescent tuberculosis, as it may worsen the condition.

Interaction

Flonasin may interact with other medications, so it is important to tell your healthcare provider about any other medications you are taking, including prescription, over-the-counter, vitamins, herbal supplements, and other alternative medicines.

Disease Interaction

Flonasin may interact with some diseases and conditions, so it is important to tell your healthcare provider about any other medical conditions you may have, including a history of tuberculosis.

Drug Interactions

Flonasin may interact with some other medications. It is important to tell your healthcare provider about all other medications you are taking, including prescription, over-the-counter, vitamins, herbal supplements, and other alternative medicines.

Food Interactions

Flonasin may interact with some foods, so it is important to tell your healthcare provider about any food items you are consuming.

Pregnancy Use

Flonasin is not recommended for use by pregnant women.

Lactation Use

Flonasin should be used with caution in women who are breastfeeding. It is not known if the active ingredients of the medication passes into breast milk.

Acute Overdose

There is no specific antidote for an acute overdose of Flonasin. Symptoms of overdose may include dizziness, nausea, vomiting, blurred vision, and drowsiness.

Contraindication

Flonasin is contraindicated for use in people who are known to be hypersensitive to azelastine or fluticasone, or any of the other ingredients in the medication.

Use Direction

Flonasin should be used as directed by your healthcare provider. The medication should be sprayed into each nostril twice daily. It is important to not exceed the recommended dose as this may cause an increased risk of side effects.

Storage Condition

Flonasin should be stored at room temperature away from moisture and direct light.

Volume of Distribution

The volume of distribution for Flonasin is 6.4L.

Half-Life

The half-life of Flonasin is 8.2 hours.

Clearance

The clearance of Flonasin is 18.8L/hr.

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