Fenoprofeno
Fenoprofeno Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Fenoprofeno is a brand name. Its generic name is Fenoprofen.
Introduction
Fenoprofeno is a nonsteroidal anti-inflammatory drug (NSAIDs) used to reduce inflammation and swelling due to illnesses like arthritis, bursitis, tendinitis, and other musculoskeletal injuries. It works by blocking certain enzymes in the body that are involved in making inflammation-causing chemicals, such as prostaglandins.
Uses
Fenoprofeno is used to reduce pain, redness, and swelling associated with certain rheumatologic and musculoskeletal conditions. Common uses include: rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, bursitis, tendinitis, muscle strains, tendinitis, plantar fasciitis, and dental pain.
Mechanism of Action
Fenoprofeno works by blocking the cyclooxygenase enzyme (COX-1 and COX-2), which helps prevent the formation of substances in the body, such as prostaglandins, thromboxanes, and leukotrienes. This inhibition helps reduce pain, swelling, and discomfort associated with rheumatologic and musculoskeletal conditions.
How Long Does It Take to Work
The effects of fenoprofen will usually be felt within 2 to 5 days. It is important to continue taking the medication as prescribed, even if you begin to feel better.
Absorption
Fenoprofeno is easily absorbed from the gastrointestinal system and reaches peak levels in the bloodstream in 1 to 4 hours. It is 80-90% bound to plasma proteins and has a half-life of 2–4 hours.
Route of Elimination
Fenoprofeno is metabolized in the liver and then excreted in the urine. Approximately 60% of an oral dose is eliminated unchanged in the urine within 24 hours.
Dosage and Administration
The recommended dose of fenoprofen calcium for adults is 200-400 mg orally every 4-8 hours. The maximum recommended dose is 3.2 g daily. It should be taken with meals or with a full glass of water to reduce stomach irritation. Do not crush, chew, or break the tablets. Swallow the tablets whole with water.
Side Effects
Common side effects include: nausea, dizziness, drowsiness, headache, diarrhea, abdominal pain, and rash. Less common but serious side effects can include: allergic reactions, blood disorders, liver damage, kidney damage, and worsening of asthma. Contact your doctor if you experience any side effects.
Toxicity
Overdosage of fenoprofen may cause renal and/or hepatic injury, gastroenteritis, and decrease in platelet count. Symptoms of overdose include dizziness, drowsiness, nausea, vomiting, abdominal pain, confusion, and coma. Treatment of overdose is supportive, including correction of electrolyte disturbances and the patient's airway. Dialysis is not effective in removing fenoprofen.
Precautions
When taking fenoprofen, make sure to:
- Inform your doctor of any allergies or medical conditions (such as asthma, high blood pressure, stomach ulcers).
- Avoid alcohol and other medications that may affect kidney function.
- Do not take if you are pregnant or breast-feeding.
- Use caution when driving or operating machinery.
Interaction
Fenoprofeno interacts with many medications. Talk to your doctor or pharmacist before taking any other over-the-counter medications, including vitamins, minerals, and herbal supplements.
Disease Interaction
Fenoprofeno may interact with certain diseases. Inform your doctor if you have any of the following diseases:
- Diabetes
- Heart disease
- High blood pressure
- Liver disease
- Kidney disease
- Stomach ulcers
- Gastrointestinal bleeding
Drug Interactions
Fenoprofeno can interact with several medications. Common drug interactions include:
- ACE inhibitors (captopril, enalapril, lisinopril, ramipril)
- Antacids (calcium carbonate, magaldrate, aluminum hydroxide)
- Diuretics (furosemide, hydrochlorothiazide, spironolactone)
- Cyclosporine
- Lithium
- Methotrexate
- Warfarin
- Diuretics (furosemide, hydrochlorothiazide, spironolactone)
Food Interactions
Fenoprofeno calcium may interact with certain foods. Avoid taking antacids, grapefruit juice and other acidic foods and drinks that may decrease the absorption of the medication.
Pregnancy Use
Fenoprofeno should be avoided in pregnancy unless clearly needed. If you are pregnant or are planning to become pregnant, talk to your doctor about the potential risks of taking fenoprofen during pregnancy.
Lactation Use
Fenoprofeno is excreted in breast milk and is not recommended for use in nursing mothers. If you are breastfeeding, it is recommended that you avoid taking this medication.
Acute Overdose
If you think you have taken too much fenoprofen, contact your health provider immediately. Symptoms of overdose include nausea, vomiting, dizziness, drowsiness, confusion, and abdominal pain. Treatment of overdose is supportive, including correction of electrolyte disturbances and the patient's airway.
Contraindications
Fenoprofeno calcium should not be used in patients with a known hypersensitivity to fenoprofen. It should also not be used in combination with other NSAIDs, such as ibuprofen or naproxen, due to an increased risk of gastrointestinal bleeding.
Use Directions
Take fenoprofen as directed by your doctor and follow the directions on the label. Do not take more or less of the medication than prescribed. Do not stop taking the medication without talking to your doctor.
Storage Conditions
Fenoprofeno should be kept in a cool dry place and should not be stored in the bathroom. Keep the medication away from heat, light, and moisture.
Volume of Distribution
The volume of distribution (Vd) of fenoprofen is 0.9 L/kg in healthy subjects. It is distributed in body tissues and is not significantly bound to plasma proteins.
Half-Life
The half-life of fenoprofen calcium is 1.9-2.3 hours in healthy subjects. It is metabolized in the liver and excreted via the kidneys.
Clearance
The clearance of fenoprofen calcium is 13-26 mL/min. It is largely eliminated unchanged in the urine. It has a low potential for producing drug interactions due to its low protein binding.
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