Eylamdo

Eylamdo Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Eylamdo is a brand name. Its generic name is Dorzolamide + Timolol.

Eylamdo: Introduction

Eylamdo is a combination medication used to treat glaucoma, a condition in which increased pressure in the eye may gradually damage the optic nerve, leading to vision loss or blindness. Eylamdo works by reducing pressure in the eye and is a combination of two drugs that act to reduce intraocular pressure (IOP). Usually, these two drugs are used together for the best results.

Uses for Eylamdo

Eylamdo is used to treat patients with open-angle glaucoma or ocular hypertension (high pressure inside the eye). This medication is used to reduce IOP by increasing aqueous humor outflow and by decreasing aqueous humor production, thereby reducing the risk of blindness caused by glaucoma.

Mechanism of Action

Dorzolamide is a topical carbonic anhydrase inhibitor and it works by inhibiting carbonic anhydrase activity in the ciliary processes of the eye. This action reduces the formation of aqueous humour and thereby decreases the intraocular pressure. Timolol is a beta-adrenergic blocking agent which works by blocking the beta-adrenergic receptor, thereby preventing vasoconstriction of the ciliary body. This causes a decreased resistance to the drainage of fluid, reducing the intraocular pressure.

How Long Does it Take to Work?

The effects of the Eylamdo combination can be felt as soon as the first dose is given. It generally takes 2-3 weeks for a full therapeutic effect to be felt.

Absorption

Dorzolamide is only absorbed from the ocular surface and is poorly absorbed systemically, with a relative bioavailability of 0.2%. Timolol is rapidly absorbed into the systemic circulation and reaches peak plasma concentrations within 2-4 hours of administration. Dorzolamide is a weak base with a pKa of 8.3 and is poorly soluble in aqueous solution, whereas Timolol is a neutral compound with a pKa of 7.6 and is highly soluble.

Route of Elimination

The components of Eylamdo are eliminated mainly through the kidneys, via glomerular filtration and tubular secretion. A small amount of Dorzolamide is metabolized to its active sulfate conjugate, which is then excreted in the bile.

Dosage and Administration

Eylamdo should be administered twice daily, with the dose depending on the patient's individual condition and response to treatment. The recommended starting dose for adults is 1 drop of the solution in each affected eye twice daily. The dose can be increased up to three times daily as necessary for the patient's condition.

Side Effects

Common side effects of Eylamdo include: conjunctival hyperemia, burning sensation, dry mouth, itching, stinging in the eyes, bitter taste, chest congestion, headache, blurred vision, and eye pain. Other possible side effects include: diarrhea, dizziness, fatigue, cough, depression, increased sensitivity to light, nasal congestion, and nausea.

Toxicity

Eylamdo is a safe medication when used as prescribed. Overdose symptoms may include drowsiness, dizziness, and confusion. If an overdose is suspected, contact your healthcare provider or seek medical attention immediately.

Precautions

Before taking Eylamdo, tell your doctor if you have a history of any serious eye conditions, vision problems, lung problems, heart disease, diabetes, kidney disease, or thyroid disease. Tell your doctor about any medications you are taking, including non-prescription medications and supplements. Eylamdo can cause an allergic reaction, so if you have swelling of the face, lips, tongue, or throat stop using the medication immediately and contact your healthcare provider.

Interactions

Eylamdo should not be used with certain drugs as it may cause serious interactions. These include other eye medications, certain antibiotics, eye drops that contain preservatives, ritonavir, certain inhalers, epinephrine, antipsychotics, and anti-seizure medications. Eylamdo may also interact with certain herb supplements and herbal teas.

Disease Interactions

The use of Eylamdo may be contraindicated in certain conditions. Patients with a history of chronic obstructive pulmonary disease, asthma, diabetes, seizures, heart disease, lung disease, and thyroid disease should not use this medication. Pregnant and nursing mothers should not use this medication as well.

Drug Interactions

Eylamdo may interact with several drugs. Common drug interactions include other eye medications, certain antibiotics, epinephrine, ritonavir, anti-seizure medications, and certain inhalers. Always tell your doctor if you are taking any other medications, including over the counter medications and supplements.

Food Interactions

Eylamdo may interact with certain foods. Grapefruit, grapefruit juice, and grapefruit seed extract can increase the concentration of Dorzolamide and therefore should not be consumed while using this medication.

Pregnancy Use

The safety of Eylamdo during pregnancy has not been established. This medication should not be used while pregnant unless the benefits to the mother outweigh any potential risks to the unborn child.

Lactation Use

Eylamdo is not recommended for use in breastfeeding women. It is not known whether this medication is excreted into human milk, and potential risks to a nursing infant should be carefully considered before using this medication.

Acute Overdose

The signs and symptoms of an acute overdose of Eylamdo may include nausea, vomiting, confusion, dizziness, drowsiness, bradycardia, hypotension, and respiratory depression. If an overdose is suspected, contact your healthcare provider or seek medical attention immediately.

Contraindications

Eylamdo has several contraindications. This medication should not be used in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma, diabetes, seizures, heart disease, peripheral vascular disease, and thyroid dysfunction. Patients with known hypersensitivity to any of the components of this medication should not use it. Eylamdo should also not be used in pregnancy and lactation.

Use Direction

Patients taking Eylamdo should use the medication exactly as directed by their doctor. The medication should not be applied more frequently than recommended. The patient should not stop taking this medication unless advised by their doctor. If the patient misses a dose, they should take the missed dose as soon as they remember.

Storage Conditions

Eylamdo should be stored at room temperature, away from moisture and heat. Keep this medication out of the reach of children and pets. Do not reuse the medication container and discard any unused medication.

Volume of Distribution

The volume of distribution of Eylamdo is not known. However, Dorzolamide exhibits low ampilification in both eyes and plasma and is not protein bound, while Timolol has a high distribution volume in plasma and is 76-88% protein bound.

Half Life

The half-life of Eylamdo is not known. The half-life of Dorzolamide is about 3 hours and the half-life of Timolol is about 8 hours.

Clearance

The clearance of Eylamdo is not known. The clearance of Dorzolamide is 0.32 L/h/kg, while the clearance of Timolol is 0.95 L/h/kg.

Dosage Information

The recommended starting dose for adults is 1 drop of the solution in each affected eye twice daily. The dose can be increased up to three times daily as necessary for the patient's condition. Patients should not exceed more than six drops a day. It is important to always follow your healthcare provider’s instructions when taking Eylamdo.

Here you find in details version of Eylamdo

Some Frequently Asked Questions About Eylamdo

What is Eylamdo?

Eylamdo is a combination medication containing dorzolamide and timolol, two medications used to treat glaucoma. It works by decreasing the production of fluid within the eye, which decreases eye pressure.

What is Dorzolamide?

Dorzolamide is a carbonic anhydrase inhibitor. It works by decreasing the production of fluid in the eye, thereby reducing eye pressure.

What is Timolol?

Timolol is a beta blocker. It works by decreasing the amount of fluid in the eye, thereby reducing eye pressure.

How is Eylamdo used?

Eylamdo is usually used once or twice a day, depending on the severity of your condition. Your doctor will advise you on how often to use Eylamdo.

What should I do if I forget to take a dose of Eylamdo?

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Is Eylamdo safe?

Eylamdo is generally safe if used as prescribed by your doctor. However, it may cause side effects such as eye irritation, headaches, and nausea. If you experience any side effects, contact your doctor immediately.

Does Eylamdo have any interactions?

Eylamdo may interact with other medications, especially beta blockers. Be sure to inform your doctor of all medications you are taking. Also, discuss any allergies you may have to avoid possible interactions.

What are the most common side effects of Eylamdo?

The most common side effects of Eylamdo are eye irritation, headaches, dizziness, blurred vision, and nausea.

What should I do if I have an allergic reaction to Eylamdo?

If you experience a severe allergic reaction to Eylamdo, stop using the medication immediately and seek medical help right away. Symptoms of a severe allergic reaction include rash, itching, difficulty breathing, and tightness in the chest.

What should I do if I experience eye irritation while taking Eylamdo?

If you experience eye irritation while taking Eylamdo, stop taking the medication and contact your doctor. Eye irritation may be a sign that the medication is not working properly.

Is Eylamdo available over the counter?

No, Eylamdo is not available over the counter. It is a prescription medication and can only be obtained with a valid prescription from a doctor.

How long does it take for Eylamdo to start working?

It typically takes a few weeks for Eylamdo to start working. Your doctor will monitor your progress and adjust the dose as needed.

Does Eylamdo cause weight gain?

No, Eylamdo does not cause weight gain. If you experience weight gain, contact your doctor as it could be a sign of another medical condition.

Can I use Eylamdo with other medications?

It is important to inform your doctor of all medications you are taking before starting Eylamdo as it may interact with other medications, or affect their effectiveness. Speak with your doctor before taking any other medications.

Can I drink alcohol while taking Eylamdo?

It is not recommended to drink alcohol while taking Eylamdo as it can increase the side effects of the medication. Speak with your doctor before having a drink.

Can I take other eye drops while taking Eylamdo?

No, it is not recommended to use other eye drops while taking Eylamdo, as it may interfere with the effectiveness or cause side effects. Speak with your doctor before using any other eye drops.

Can Eylamdo lower blood pressure?

Yes, as Timolol is a beta blocker, Eylamdo may lower blood pressure. Your doctor may recommend that you monitor your blood pressure while taking this medication.

Does Eylamdo treat glaucoma?

Yes, Eylamdo is used to treat glaucoma by decreasing production of fluid within the eye, which decreases eye pressure.

Does Eylamdo make your vision worse?

No, Eylamdo should not make your vision worse. If your vision changes or decreases, contact your doctor as soon as possible.

Can I use contact lenses while taking Eylamdo?

It is not recommended to wear contact lenses while taking Eylamdo, as the medication may cause eye irritation. Speak with your doctor before using contact lenses while taking this medication.

Can I use other eye medications while taking Eylamdo?

No, other eye medications, such as those for dry eyes or allergy relief, should not be used while taking Eylamdo. Speak with your doctor before using any other eye medications.

Can Eylamdo be used for children?

Yes, Eylamdo can be used in children. The dosage and frequency may need to be adjusted depending on the age and severity of the child's condition.

Can pregnant women use Eylamdo?

Women who are pregnant should not use Eylamdo unless prescribed by their doctor. The medication may have an adverse effect on a developing fetus, so speak with your doctor before taking this medication.

Can Eylamdo cause dry eyes?

Yes, Eylamdo can cause dry eyes as a side effect. If you experience dry eyes, contact your doctor.

Can Eylamdo cause blurred vision?

Yes, blurred vision can be a side effect of taking Eylamdo. If you experience blurred vision, contact your doctor.

What should I do if I experience nausea while taking Eylamdo?

If you experience nausea while taking Eylamdo, stop taking the medication and contact your doctor. It may be a sign that the medication is not working properly.

Does Eylamdo interact with birth control?

Eylamdo may interact with certain birth control medications, so it is important to inform your doctor of any medications you are taking before starting this medication. Speak with your doctor about any possible interactions.

Can Eylamdo cause hyperglycemia?

Yes, Eylamdo can cause hyperglycemia in some people. If you experience any of the symptoms of hyperglycemia (increased thirst or urination, increased hunger, fatigue, or weight loss), contact your doctor immediately.

Can I take other medications while taking Eylamdo?

It is important to inform your doctor of all medications you are taking before starting Eylamdo as it may interact with other medications or affect their effectiveness. Speak with your doctor before taking any other medications.

Can I take cold medicine while taking Eylamdo?

It is not recommended to take cold medicine while taking Eylamdo as it may interact with the medication. Speak with your doctor before taking cold medicine while taking this medication.

Can I take other eye medications while taking Eylamdo?

No, other eye medications, such as those for dry eyes or allergy relief, should not be used while taking Eylamdo. Speak with your doctor before using any other eye medications.

Can I wear sunglasses while taking Eylamdo?

Yes, you can wear sunglasses while taking Eylamdo. Sunglasses may be beneficial in reducing glare and protecting your eyes.

Is Eylamdo available in generic form?

Yes, Eylamdo is available in generic form. Some brands of Eylamdo may not be available in generic form.

Can I stop taking Eylamdo suddenly?

No, you should not stop taking Eylamdo suddenly as this can cause your eye pressure to increase suddenly. Check with your doctor before stopping the medication.

Can I take other glaucoma medications while taking Eylamdo?

No, it is not recommended to take other glaucoma medications while taking Eylamdo, as this may interfere with the effectiveness or cause side effects. Speak with your doctor before taking any other glaucoma medications.

Can I take other health supplements while taking Eylamdo?

Yes, other health supplements, such as vitamins or herbal products, can be taken while taking Eylamdo. Speak with your doctor before taking any other supplements.

Can Eylamdo cause headaches?

Yes, headaches can be a side effect of taking Eylamdo. If you experience severe or frequent headaches, contact your doctor as soon as possible.

What should I do if I experience dizziness while taking Eylamdo?

If you experience dizziness while taking Eylamdo, stop taking the medication and contact your doctor. It may be a sign that the medication is not working properly.