Eselex
Eselex Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Eselex is a brand name. Its generic name is Selegiline.
Introduction
Eselex is an antidepressant drug used mainly in the treatment of major depressive disorder (MDD) and Parkinson's disease (PD). It is a monoamine oxidase (MAO) inhibitor and has a relatively milder side effect profile compared to other MAO inhibitors.Uses
Eselex is used to treat major depression, Parkinson's disease and certain other disorders such as cognitive impairment.Mechanism of Action
Eselex works through the inhibition of the enzyme monoamine oxidase (MAO). By blocking MAO, the drug prevents the breakdown of neurotransmitters such as norepinephrine, serotonin, and dopamine. This, in turn, increases the availability of these neurotransmitters in the body and brain, which can lead to increased mood and improved motor control in patients with Parkinson's disease.How Long Does it Take to Work?
The effects of selegiline usually begin to take effect within several weeks. The full effect may take several months. It is important to continue to take the medication as prescribed even if symptoms improve after a few weeks.Absorption
Eselex is rapidly and almost completely absorbed from the gastrointestinal tract (GI) after oral administration. Absorption is highest when taken with a meal.Route of Elimination
Eselex is metabolized mainly in the liver by the enzyme MAO, and is then rapidly eliminated, mainly in the urine.Dosage
Eselex is available in the form of tablets ranging from 5 to 10 mg. The usual starting dose is 5 mg once daily in the morning. The dose can be increased gradually up to 10 mg once daily. If therapy is stopped, the dose should be gradually reduced over several weeks.Administration
Eselex should be taken with food, once daily in the morning. It should be swallowed whole with a glass of water.Side Effects
Common side effects of selegiline include nausea, dizziness, drowsiness, insomnia, sexual dysfunction, dry mouth, and headache. Rarely, more serious side effects such as depression, high blood pressure, and irregular heart rate can occur.Toxicity
Eselex is generally well-tolerated and has no known serious toxicity. However, in high doses, it can cause symptoms such as nervousness, agitation, tremors, and high blood pressure.Precautions
Eselex should not be taken with certain other medications, such as corticosteroids, meperidine, serotonin reuptake inhibitors, and amphetamines. In addition, selegiline should not be taken by pregnant or nursing women, or by patients with certain medical conditions such as liver, kidney, or thyroid disease.Interaction
Eselex can interact with other medications, such as MAO inhibitors, alcohol, and certain anti-depressants. It may also interact with certain supplements. Therefore, it is important to always tell healthcare providers about all medications and supplements that are being taken.Disease Interaction
Eselex may worsen certain medical conditions, such as hypertension, heart failure, and seizures. Therefore, patients with these conditions should be monitored closely while taking selegiline.Drug Interaction
Certain drugs that affect the central nervous system, such as lithium, reserpine, and opioid painkillers, can interact with selegiline. Therefore, it is important to inform healthcare providers about all drugs that are currently being taken.Food Interactions
Certain foods, such as elderberry, avocado, and fermented foods, can interact with selegiline and should be avoided when taking this medication.Pregnancy Use
Eselex is classified as a pregnancy category C drug, meaning it is not recommended for use during pregnancy.Lactation Use
Eselex is classified as a lactation category L2 drug, meaning it is not recommended for use while breastfeeding.Acute Overdose
An acute overdose of selegiline can cause severe side effects such as nervousness, agitation, and tremors. If an overdose is suspected, medical attention should be sought immediately.Contraindication
Eselex should not be used in patients with narrow-angle glaucoma, cardiovascular disease, or certain types of dementia.Use Direction
Eselex should be taken as directed by a healthcare provider. Patients should not take more or less medication than directed, and should not stop taking the medication suddenly, as this can cause withdrawal symptoms.Storage Condition
Eselex should be stored in a cool, dry place away from direct light. It should also be kept away from children and pets.Volume of Distribution
The volume of distribution of selegiline is approximately 8.8 L/kg.Half Life
The half-life of selegiline is approximately 0.3 to 4.5 hours.Clearance
The clearance of selegiline is approximately 6.9 L/hr/kg.Here you find in details version of Eselex
Some Frequently Asked Questions About Eselex
What is selegiline?
Eselex is an antidepressant medication that is sometimes used to treat major depression in adults. It is also used to treat Parkinson’s disease, as well as symptoms caused by the disease. It works by increasing dopamine, a neurotransmitter in the brain that helps regulate movement and other functions.
How does selegiline work?
Eselex works by blocking the enzyme monoamine oxidase B (MAO-B). This enzyme is involved in the breakdown of dopamine. By blocking this enzyme, selegiline increases the level of dopamine in the brain, which helps to regulate movement and other functions.
What is the recommended dosage of selegiline?
The dosage of selegiline depends on the condition being treated. For the treatment of Parkinson’s disease, the typical starting dose is 5 mg once a day. The dose can be increased to 10 mg once a day, but should not be increased beyond that dose. For the treatment of major depression, the typical starting dose is 6 mg once a day. The dose can be increased to 12 mg once a day, but should not be increased beyond that dose.
What are the side effects of selegiline?
Common side effects of selegiline include dizziness, headache, nausea, vomiting, insomnia, dry mouth, and constipation. Serious side effects include confusion, agitation, seizures, hallucinations, chest pain, fainting, or irregular heartbeat. If you experience any of these side effects, tell your healthcare provider right away.
Is selegiline safe?
Eselex is generally safe when used as directed. However, like all medications, it can cause side effects. It is important to talk to your healthcare provider about possible side effects and any other concerns you may have.
What is the difference between selegiline and levodopa?
Eselex and levodopa are both used to treat Parkinson’s disease. Eselex works by blocking the enzyme monoamine oxidase B (MAO-B), which helps to increase the level of dopamine in the brain. Levodopa is converted to dopamine in the brain, which helps to regulate movement and other functions. Levodopa is more effective than selegiline in treating the symptoms of Parkinson’s, so it is usually prescribed first.
What drugs interact with selegiline?
Eselex should not be taken with certain medications that can interact with it, such as MAO inhibitors, anti-psychotics, antibiotics, and some antidepressants. Always check with your healthcare provider before taking any new medications.
Does selegiline cause weight gain?
Eselex can cause weight gain, although this is not usually a severe side effect. If you are concerned about weight gain, talk to your healthcare provider about other treatment options.
Does selegiline cause sleep problems?
Eselex can cause insomnia, which is difficulty falling asleep or staying asleep. If you experience insomnia while taking selegiline, tell your healthcare provider so they can help you manage your symptoms and adjust your dosage if needed.
Is selegiline a controlled substance?
No, selegiline is not a controlled substance. It is a prescription medication that is available as a tablet, capsule, or oral solution.
Can children take selegiline?
No, selegiline is not approved by the FDA for use in children. It should only be used by adults 18 years and older.
Can pregnant women take selegiline?
Eselex should not be taken by pregnant women. It is an FDA category C medication, which means it is not known if it is safe for use during pregnancy.
Can selegiline be taken with other medications?
Yes, selegiline can be taken with other medications, however, some medications may interact with each other and should not be taken together. Always check with your healthcare provider before starting or stopping any medications.
What are the most common side effects of selegiline?
The most common side effects of selegiline include dizziness, headache, nausea, vomiting, insomnia, dry mouth, and constipation.
Can selegiline cause confusion?
Yes, selegiline can cause confusion. This is considered to be a serious side effect and should be reported to your healthcare provider right away.
Does selegiline cause a euphoric feeling?
No, selegiline does not usually cause a euphoric feeling. In fact, selegiline may cause decreased pleasure and difficulty in motivating oneself. These side effects should be reported to your healthcare provider.
Does selegiline cause withdrawal symptoms?
Yes, selegiline can cause withdrawal symptoms when it is stopped abruptly. It is important to follow your healthcare provider’s instructions for tapering off of the medication to avoid withdrawal symptoms.
Can selegiline be used to treat anxiety?
No, selegiline is not approved by the FDA to treat anxiety. It is approved for the treatment of major depressive disorder and Parkinson’s disease.
Can selegiline cause depression?
No, selegiline is not known to cause depression. In fact it is used to treat major depression in adults. However, it can cause other side effects such as confusion, agitation, insomnia, and dry mouth.
Can selegiline cause hallucinations?
Yes, selegiline can cause hallucinations. This is considered to be a serious side effect and should be reported to your healthcare provider right away.
What is the recommended dosage for the treatment of Parkinson's disease?
The recommended starting dosage for the treatment of Parkinson’s disease is 5 mg once a day. The dose can be increased to 10 mg once a day, but should not be increased beyond that dose.
What is the recommended dosage for the treatment of major depression?
The recommended starting dosage for the treatment of major depression is 6 mg once a day. The dose can be increased to 12 mg once a day, but should not be increased beyond that dose.
Does selegiline treat the symptoms of Parkinson's disease?
Yes, selegiline helps to treat the symptoms of Parkinson’s disease by increasing dopamine in the brain, which helps to regulate movement and other functions.
Can selegiline be taken with other antidepressants?
Yes, selegiline can be taken with other antidepressants, however, some medications may interact with each other and should not be taken together. Always check with your healthcare provider before taking any new medications.
Does selegiline help to reduce symptoms of depression?
Yes, selegiline can help to reduce the symptoms of depression. It is an antidepressant that works by increasing dopamine in the brain, which can help to reduce symptoms of depression.
Can selegiline be used to treat dementia?
No, selegiline is not approved by the FDA to treat dementia. It is only approved for the treatment of major depressive disorder and Parkinson’s disease.
Should selegiline be taken with food?
Yes, selegiline should be taken with food, preferably with a meal. This helps to prevent nausea and other gastrointestinal side effects.
How long does it take for selegiline to start working?
The effects of selegiline can vary from person to person. You may start to feel the effects within a few weeks, although it can take up to 6 weeks to feel the full effects of the medication.
Can selegiline cause an increase in blood pressure?
Yes, selegiline can cause an increase in blood pressure. It is important to monitor your blood pressure regularly while taking selegiline.
Does selegiline increase appetite?
Yes, selegiline can cause an increase in appetite. This may lead to weight gain, so it is important to talk to your healthcare provider about possible ways to manage your weight while taking selegiline.
Can selegiline cause a decrease in libido?
Yes, selegiline can cause a decrease in libido. This side effect can be managed by reducing the dose or switching to another medication.
Can selegiline be taken long-term?
Yes, selegiline can be taken long-term. However, long-term use of the medication should be monitored by your healthcare provider to ensure that it is safe and effective.
Can selegiline cause liver damage?
Eselex has been known to cause liver damage. It is important to tell your healthcare provider if you notice any signs or symptoms of liver damage such as dark urine, yellowing of the eyes or skin, or abdominal pain.
What are the symptoms of overdose with selegiline?
Symptoms of a selegiline overdose may include agitation, seizures, coma, and irregular heartbeat. If you suspect an overdose, seek medical attention immediately.
Should selegiline be taken at night or in the morning?
The best time to take selegiline will depend on when your symptoms are worse. Your healthcare provider can advise you on the best time of day to take your medication.
Can selegiline be used to treat bipolar disorder?
No, selegiline is not approved by the FDA to treat bipolar disorder. It is approved for the treatment of major depressive disorder and Parkinson’s disease.
Can selegiline cause dizziness?
Yes, selegiline can cause dizziness. This is a common side effect of the medication, and should improve as your body adjusts to the medication. However, if the dizziness persists, talk to your healthcare provider.
Can selegiline cause nausea?
Yes, selegiline can cause nausea. It is important to take the medication with food to help reduce nausea. If the nausea persists, talk to your healthcare provider.
Is selegiline addictive?
No, selegiline is not known to be addictive. However, sudden discontinuation of the medication can cause withdrawal symptoms. It is important to discuss tapering off of the medication with your healthcare provider.
Can selegiline be used to treat dementia-related symptoms?
No, selegiline is not approved by the FDA to treat dementia-related symptoms. It is approved for the treatment of major depressive disorder and Parkinson’s disease.