Eptiba
Eptiba Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Eptiba is a brand name. Its generic name is Eptifibatide.
Introduction
Eptiba is a cyclic heptapeptide used to prevent thrombosis (formation of blood clots) in patients with unstable angina or coronary artery disease. It is often referred to as a glycoprotein IIb/IIIa inhibitor.
Uses for
Eptiba is used to prevent thrombosis (blood clots) in patients with unstable angina or coronary artery disease. It is also used to treat additional cardiac disorders such as myocardial infarction (heart attack).
Mechanism of Action
Eptiba works by blocking the platelet glycoprotein IIb / IIIa receptor, preventing the binding of fibrinogen to platelets, and thus blocking the formation of a thrombus.
How Long Does it take to Work?
Eptiba usually starts to work within 20 minutes of administration. The full therapeutic effect of Eptiba can be accomplished in as little as an hour.
Absorption
Eptiba is rapidly absorbed after intravenous administration and its bioavailability is approximately 100%.
Route of Elimination
Eptiba is eliminated from the body primarily by the kidneys.
Dosage
The standard recommended dose of Eptiba is 180 µg/Kg (maximum of 18 mg) administered by intravenous infusion over 10 minutes. The infusion should be repeated with 90 µg/Kg (maximum of 9 mg) over one hour, followed by an additional infusion of 0.75 µg/Kg/minute (maximum of 7.5 mg per hour) as required.
Administration
Eptiba should only be administered under the supervision of a qualified medical practitioner. It should be given as an intravenous infusion.
Side Effects
Eptiba may cause side effects such as nausea, vomiting, headache, dizziness, back pain, chest pain, diarrhea, weakness, and rash. If any of these side effects are experienced, the patient should contact their physician immediately.
Toxicity
Eptiba is generally well tolerated. Overdose of Eptiba may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators.
Precaution
Eptiba should be used with caution in patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Interaction
Eptiba is known to interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Disease Interaction
Eptiba may be contraindicated in certain patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Drug Interaction
Eptiba may interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Food Interactions
Eptiba is known to interact with certain foods, such as grapefruit juice. Grapefruit juice should be avoided when taking Eptiba.
Pregnancy Use
Eptiba should not be used in pregnant women as safety in this population has not been established.
Lactation Use
Eptiba should be used with caution in breastfeeding women as it is not known if the drug passes into breast milk.
Acute Overdose
Overdose of Eptiba may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators. In cases of serious overdose, seek immediate medical attention.
Contraindication
Eptiba is contraindicated in patients with a history of bleeding disorders, recent surgery, or any other conditions in which bleeding is a risk.
Use Direction
Eptiba must only be administered by a qualified medical practitioner. It must be given as an intravenous infusion per the instruction of the prescribing physician.
Storage Condition
Eptiba should be stored at a temperature between 20-25°C.
Volume of Distribution
The volume of distribution of Eptiba is estimated as 118 liters.
Half Life
The elimination half-life of Eptiba is approximately 4.07 hours.
Clearance
The clearance of Eptiba is estimated as 11 liters/hour.
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