Dulonor P
Dulonor P Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dulonor P is a brand name. Its generic name is Flunarizine + Propranolol.
Introduction
Flunarizine and Propranolol are medications used for treating a variety of conditions, including anxiety, high blood pressure, and heart rhythm disturbances. Flunarizine is a calcium channel blocker while Propranolol is a beta-blocker. Together, these two medications can help regulate abnormal heart rhythms and reduce the risk of a stroke or heart attack.Uses
The combination of Flunarizine and Propranolol is used to treat conditions such as abnormally fast heart rate (tachycardia), hypertension, angina, migraine headaches, and for preventing strokes and heart attacks.Mechanism of Action
Flunarizine is a type of calcium channel blocker, meaning it blocks the calcium channels in the body. This helps to reduce spasm of the arteries and arterioles, leading to lowered blood pressure. Propranolol is a beta-blocker, which blocks certain hormones and chemicals from reaching the heart, such as adrenaline. This reduces the heart rate and blood pressure, resulting in a lower risk of stroke and heart attack.How Long Does it Take to Work?
Flunarizine and Propranolol usually start to work within 1-2 hours after taking it. However, it may take up to 2 weeks for the full effects to be seen.Absorption
Flunarizine is rapidly absorbed into the bloodstream after ingestion and is bioavailable about 75% when taken by mouth. Propranolol is also rapidly absorbed into the bloodstream after ingestion and is bioavailable about 90%.Route of Elimination
Flunarizine is metabolized in the liver and the metabolites are excreted in the urine and feces. Propranolol is also metabolized in the liver and is mainly excreted in the urine with some excreted in the feces.Dosage
The recommended dosage of Flunarizine and Propranolol is based on the condition being treated. Generally the recommended initial dose of Flunarizine is 10-20mg per day, and the recommended dose of Propranolol is 8-160mg per day. This dose can be adjusted according to the condition of the patient and the response to the medication.Administration
Flunarizine and Propranolol are usually administered orally with some food. The dose should be taken at the same time each day to maintain even levels of the medication in the body.Side Effects
The most common side effects of Flunarizine and Propranolol include tiredness, nausea, dizziness, headache, vomiting, abdominal pain, and diarrhea. In rare cases, more serious side effects can occur such as fainting, difficulty breathing, rash, and hives.Toxicity
The toxic effects of Flunarizine and Propranolol are usually mild and reversible with treatment. Overdose of either medication can cause dizziness, low blood pressure, fainting, irregular heart beats, confusion, difficulty breathing, and coma.Precautions
Flunarizine and Propranolol should not be used in patients with certain health conditions, such as asthma, allergies to either medication, severe heart failure, uncontrolled heart rhythm disturbances, or during breastfeeding. Patients should tell their healthcare provider about all medications they are currently taking, as some medications may interact with Flunarizine and Propranolol.Interactions
Flunarizine and Propranolol can interact with other medications, including some antibiotics, antifungals, antidepressants, and heart medications. Patients should talk to their healthcare provider before taking any new medications while taking these medications.Disease Interaction
Flunarizine and Propranolol may interact with certain diseases, including liver or kidney disease, heart problems, lung problems, high blood pressure, low blood pressure, and diabetes. Patients should talk to their healthcare provider to ensure the medications are safe to take with their existing medical condition.Drug Interaction
Flunarizine and Propranolol may interact with certain drugs, including antacids, sodium bicarbonate, antidepressants, antifungals, antibiotics, and blood thinners. Patients should talk to their healthcare provider before taking any new medications or supplements while taking these medications.Food Interactions
Flunarizine and Propranolol should be taken with food to reduce the risk of side effects. Grapefruit can increase the amount of medication absorbed in the body, so patients should avoid taking Flunarizine and Propranolol with grapefruit or grapefruit juice.Pregnancy Use
Flunarizine and Propranolol should be used with caution in pregnant women. There is limited research on the effects of these medications in pregnant women and the potential risks of taking them.Lactation Use
Flunarizine and Propranolol should be used with caution in breastfeeding women. There is limited research on the effects of these medications in breastfeeding women and the potential risks of taking them.Acute Overdose
The symptoms of an acute overdose of Flunarizine and Propranolol may include dizziness, low blood pressure, irregular heart beats, confusion, difficulty breathing, and coma. It is important to seek medical attention right away if any of these symptoms occur.Contraindication
Flunarizine and Propranolol should not be used in patients with certain health conditions, including severe heart failure, uncontrolled heart rhythm disturbances, asthma, allergies to either medication, and during breastfeeding.Use Direction
Flunarizine and Propranolol should be taken exactly as prescribed by a healthcare provider. Patients should not take more or less of the medication or skip doses as this can increase the risk of side effects and reduce the effectiveness of the medications.Storage Condition
Flunarizine and Propranolol should be stored at room temperature in a tightly-closed container away from moisture and heat.Volume of Distribution
Flunarizine has a volume of distribution of 1.2-1.3 L/kg and Propranolol has a volume of distribution of 2-3 L/kg.Half Life
Flunarizine has a half-life of 6-14 hours and Propranolol has a half-life of 3-10 hours.Clearance
Flunarizine has a clearance of 27.6 ml/min/kg and Propranolol has a clearance of 17-28 ml/min/kg.Here you find in details version of Dulonor P