Dried Aluminium Hydroxide
Dried Aluminium Hydroxide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dried Aluminium Hydroxide is a brand name. Its generic name is Aluminum hydroxide.
Aluminum Hydroxide
Aluminum Hydroxide is an antacid that is used to reduce stomach acid and provide relief from stomach and occasional heartburn. It is a basic compound that combines with acidic compounds to form a salt and water. It is available in oral form and is available in combination with certain other medications such as ranitidine and famotidine.
Introduction
Aluminum Hydroxide is used to treat excessive stomach acid production and heartburn due to gastroesophageal reflux disease. It decreases the production of stomach acid by binding with and blocking the production of an enzyme (gastric acid-producing H+/K+-ATPase) necessary for acid production. It can be used alone or in combination with other medications to treat mild to severe symptoms.
Uses
- Treating gastroesophageal reflux disease (GERD).
- Relieving heartburn, indigestion, and acid reflux.
- Preventing and treating ulcers.
- Alleviating symptoms of gastritis.
Mechanism of Action
Aluminum Hydroxide works by binding to and neutralizing enzymes necessary for acidic production in the stomach. It works by forming a gel that coats the stomach lining, thus decreasing the amount of acid that reaches the lower esophagus and stomach and providing short-term relief of symptoms.
How Long Does it Take to Work?
Aluminum Hydroxide typically works within minutes to provide relief of symptoms. The effects usually last up to four hours.
Absorption
Aluminum Hydroxide is not absorbed into the bloodstream and thus does not reach systemic circulation.
Route of Elimination
Aluminum Hydroxide is eliminated in the stool with very little absorption in the gastrointestinal tract.
Dosage
The recommended adult dosage of Aluminum Hydroxide is as follows:
- For mild to moderate symptoms: 250-500 mg taken orally four times daily.
- For severe symptoms: 500-1000 mg taken orally four times daily.
Administration
Aluminum Hydroxide is generally taken orally, with or without food, and should be taken as directed by a physician.
Side Effects
Common side effects of Aluminum Hydroxide include constipation, nausea, vomiting, and abdominal pain. Rare but serious side effects may include dehydration, electrolyte imbalances, and kidney damage.
Toxicity
Aluminum Hydroxide is considered to be of low toxicity and no fatalities have been reported. However, prolonged exposure to high doses of aluminum may cause toxicity. Prolonged absorption of aluminum into the body can lead to bone disease, anemia, dementia, and Alzheimer-like symptoms.
Precautions
- Patients with kidney impairment should take Aluminum Hydroxide with caution as it can accumulate in the body and cause toxicity and an increased risk of side effects.
- Patients should avoid taking Aluminum Hydroxide with other medications that contain aluminum as it can increase the side effects.
- Patients should avoid taking Aluminum Hydroxide with other medications that cause constipation.
- Patients should avoid taking Aluminum Hydroxide with laxatives, as they may decrease the absorption of aluminum.
Interactions
Aluminum Hydroxide may interact with certain medications, dietary supplements, vitamins, and herbal remedies. People should inform their doctor if they are taking any other medication before taking Aluminum Hydroxide.
Disease Interaction
Dried Aluminium Hydroxide may interact with certain diseases, such as chronic kidney disease, as it can accumulate in the body and cause toxicity and an increased risk of side effects. People should inform their doctor if they have any existing disease before taking Aluminum Hydroxide.
Drug Interaction
Aluminum Hydroxide may interact with certain drugs, such as aspirin, ibuprofen, magnesium citrate, and simethicone. People should inform their doctor if they are taking any other drugs before taking Aluminum Hydroxide.
Food Interaction
Aluminum Hydroxide should be taken at least one hour before or one hour after meals.
Pregnancy Use
The safety of Aluminum Hydroxide during pregnancy has not been established. It is recommended that pregnant women consult a doctor before using Aluminum Hydroxide.
Lactation Use
The safety of Aluminum Hydroxide during lactation has not been established. It is recommended that breastfeeding mothers consult a doctor before using Aluminum Hydroxide.
Acute Overdose
Acute overdose of Aluminum Hydroxide may cause stomach pain, nausea, vomiting, and constipation. Patients should seek immediate medical attention in case of an overdose.
Contraindication
Aluminum Hydroxide should not be used by patients who are allergic to any of its components.
Use Direction
Aluminum Hydroxide should be taken as prescribed by a physician. The dosage should be taken at least one hour before or one hour after meals. The drug should not be taken with other medications that contain aluminum, laxatives, or tend to cause constipation.
Storage Condition
Aluminum Hydroxide should be stored in a cool, dry place and away from direct sunlight. The drug should be used within three months of opening the bottle.
Volume of Distribution
Aluminum Hydroxide is not well distributed in the body because it is not absorbed systemically.
Half Life
The half-life of Aluminum Hydroxide is not known, as it is not absorbed into the bloodstream.
Clearance
Aluminum Hydroxide is not cleared from the body as it is not absorbed into the bloodstream.
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