Dormodor
Dormodor Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dormodor is a brand name. Its generic name is Flurazepam Hydrochloride.
Introduction
Flurazepam hydrochloride (brand name Dalmane) is a benzodiazepine drug used primarily for the treatment of insomnia. It is most commonly prescribed for short-term treatment of severe insomnia, and with appropriate medical supervision, it is considered an excellent and effective sleep aid.
Uses
Flurazepam is commonly used to treat the following conditions:
- Short-term, severe insomnia
- Sleep disturbances that are associated with depression
- Anxiety
Mechanism of Action
Flurazepam works by increasing the action of the brain chemical gamma-Aminobutyric acid (GABA). GABA is a neurotransmitter responsible for regulating several different activities, including the control of the body’s sleep-wake cycle and anxiety levels. When taken, flurazepam enhances the activity of GABA receptors, helping to bring about an enhanced sense of calm and relaxation. As a result, it can help reduce the amount of time it takes to fall asleep as well as decreasing the amount of night awakenings.
How Long Does it Take to Work?
Flurazepam usually begins to work within 30 to 60 minutes after ingestion.
Absorption
Flurazepam is rapidly absorbed into the bloodstream after oral administration. The peak plasma concentration of the drug is reached after about two to three hours.
Route of Elimination
Flurazepam is mainly excrete via the urine, with a small percentage being metabolized in the liver.
Dosage
The recommended adult dose for flurazepam is 15-30 mg at bedtime. Patients should take the lowest effective dose and for no longer than 14 days. The maximum dose should not exceed 30 mg per day. The dose for elderly patients (aged 65 and above) should be reduced to 15 mg per day.
Administration
Flurazepam is usually taken immediately before going to bed. It should be taken only as prescribed by a doctor and should not be taken in larger amounts or for a longer period of time than directed. It is not recommended to take the medication with food or alcohol.
Side Effects
Common side effects associated with flurazepam include:
- Drowsiness
- Fatigue
- Dizziness
- Lightheadedness
- Memory loss
Toxicity
Flurazepam has a low potential for toxicity when used in correct doses. The half-life of flurazepam ranges from 18 to 40 hours, so common symptoms of toxicity can last up to two days.
Precautions
Flurazepam should only be taken under the supervision of a doctor. Patients should not stop taking flurazepam suddenly as withdrawal symptoms could occur. Flurazepam should not be taken with alcohol or other Central Nervous System (CNS) depressants.
Interactions
Flurazepam may interact with certain medications, including antidepressants, sedatives, tranquilizers, and alcohol. Patients should tell their doctor about any other medications or supplements they are taking before using flurazepam.
Disease Interactions
Flurazepam should not be used by patients with narrow-angle glaucoma, severe liver disease, sleep apnea, depression, or by pregnant or breastfeeding women. Patients with underlying health problems should discuss the use of flurazepam with their doctor.
Drug Interactions
Flurazepam may interact with other drugs, including:
- Fluoxetine
- Sertraline
- Omeprazole
- Paroxetine
- Nortriptyline
Food Interactions
Flurazepam may interact with certain foods, including alcohol, caffeine, and grapefruit juice. Patients should avoid these foods while taking flurazepam.
Pregnancy Use
Flurazepam should not be used by pregnant women. The safety of this drug has not been established in pregnant women. It is not recommended to use flurazepam during breastfeeding.
Lactation Use
Flurazepam should not be used by breastfeeding mothers. The safety of this drug has not been established in breastfeeding mothers.
Acute Overdose
The effects of an overdose of flurazepam can range from mild to life threatening. Overdoses usually cause unusual sleepiness, confusion, slurred speech, blurred vision, nausea, and vomiting. If an overdose is suspected, seek medical attention immediately.
Contraindication
Flurazepam should not be used by patients with narrow-angle glaucoma, severe liver disease, sleep apnea, depression, or by pregnant or breastfeeding women.
Use Direction
Flurazepam should be taken exactly as prescribed by a doctor. The recommended dose is 15-30 mg at bedtime. The dose for elderly patients (aged 65 and above) should be reduced to 15 mg per day. Flurazepam should not be taken with food or alcohol.
Storage Condition
Flurazepam should be stored at room temperature, away from heat, light, and moisture.
Volume of Distribution
Flurazepam has a volume of distribution of 80 liters.
Half Life
Flurazepam has a half life of 18 to 40 hours.
Clearance
Flurazepam has a clearance of 0.1 liters per minute.
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