Dolonil

Dolonil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dolonil is a brand name. Its generic name is Tramadol.

Dolonil

Dolonil, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Dolonil also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Dolonil is available in both immediate-release and extended-release forms.

Uses For Dolonil

Dolonil is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Dolonil is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Dolonil works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Dolonil also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Dolonil typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Dolonil is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Dolonil is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Dolonil depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Dolonil can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Dolonil include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Dolonil is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Dolonil should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Dolonil should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Dolonil may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Dolonil may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Dolonil can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Dolonil should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Dolonil is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Dolonil should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Dolonil is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Dolonil should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Dolonil should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Dolonil has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Dolonil has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Dolonil has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Dolonil

Some Frequently Asked Questions About Dolonil

What is Dolonil?

Dolonil is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Dolonil?

Dolonil's generic name is Ultram.

What is the mechanism of action of Dolonil?

Dolonil works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Dolonil a controlled substance?

Yes, Dolonil is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Dolonil work?

Dolonil works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Dolonil be taken?

Dolonil should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Dolonil?

The most common side effects of Dolonil include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Dolonil together?

Yes, acetaminophen and Dolonil can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Dolonil?

Signs of an overdose of Dolonil include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Dolonil be used for back pain?

Yes, Dolonil is often prescribed for the treatment of back pain.

Is Dolonil addictive?

Yes, Dolonil can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Dolonil?

If you forget to take a dose of Dolonil, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Dolonil be taken with alcohol?

No, Dolonil should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Dolonil?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Dolonil safe for long-term use?

Dolonil is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Dolonil be taken during pregnancy?

Dolonil should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Dolonil if I have a history of drug abuse?

No, Dolonil should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Dolonil show up on a drug test?

Yes, Dolonil may show up on a drug test, though the results may vary depending on the type of test.

Can I take Dolonil if I have liver or kidney disease?

Dolonil should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Dolonil with anti-anxiety medications?

No, Dolonil should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Dolonil?

If you experience any side effects from Dolonil, contact your doctor as soon as possible.

What other pain relievers can be taken with Dolonil?

Dolonil can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Dolonil?

The maximum daily dose of Dolonil is 400 milligrams per day for adults.

Does Dolonil cause constipation?

Yes, constipation is a common side effect of Dolonil.

Can I take Dolonil and Dolonil Plus together?

No, Dolonil and Dolonil Plus should not be taken together as it may increase the risk of adverse reactions.

Can Dolonil be taken for headaches?

Yes, Dolonil is often prescribed for the treatment of headaches.

Is Dolonil ever prescribed for arthritis?

Yes, Dolonil is sometimes prescribed for the treatment of arthritis.

Does Dolonil interact with other medications?

Yes, Dolonil may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Dolonil.

Can Dolonil be taken for menstrual cramps?

Yes, Dolonil can be prescribed for the treatment of menstrual cramps.

Can Dolonil be crushed for easier swallowing?

No, Dolonil should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Dolonil be used to treat?

Dolonil may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Dolonil while breastfeeding?

No, Dolonil should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Dolonil be taken with anti-depressants?

Yes, Dolonil can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Dolonil be taken with vitamins or supplements?

Yes, Dolonil can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Dolonil.

Can Dolonil be taken with antihistamines?

Yes, Dolonil can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Dolonil with other pain relievers?

No, Dolonil should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Dolonil metabolized by the liver?

Yes, Dolonil is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Dolonil.

How long will Dolonil stay in my system?

Dolonil can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Dolonil?

If you miss a dose of Dolonil, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Dolonil while taking other medications?

Yes, Dolonil can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Dolonil.

Does Dolonil affect blood pressure?

Yes, Dolonil may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Dolonil HCL?

Dolonil HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Dolonil?

The withdrawal symptoms of Dolonil may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Dolonil cause hallucinations?

Yes, Dolonil can cause hallucinations, especially at higher doses.

Is Dolonil the same as Vicodin?

No, Dolonil and Vicodin are different medications. Dolonil is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Dolonil be taken with other medications for pain?

Yes, Dolonil can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Dolonil.