Dolodol

Dolodol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dolodol is a brand name. Its generic name is Tramadol.

Dolodol

Dolodol, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Dolodol also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Dolodol is available in both immediate-release and extended-release forms.

Uses For Dolodol

Dolodol is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Dolodol is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Dolodol works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Dolodol also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Dolodol typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Dolodol is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Dolodol is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Dolodol depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Dolodol can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Dolodol include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Dolodol is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Dolodol should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Dolodol should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Dolodol may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Dolodol may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Dolodol can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Dolodol should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Dolodol is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Dolodol should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Dolodol is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Dolodol should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Dolodol should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Dolodol has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Dolodol has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Dolodol has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Dolodol

Some Frequently Asked Questions About Dolodol

What is Dolodol?

Dolodol is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Dolodol?

Dolodol's generic name is Ultram.

What is the mechanism of action of Dolodol?

Dolodol works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Dolodol a controlled substance?

Yes, Dolodol is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Dolodol work?

Dolodol works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Dolodol be taken?

Dolodol should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Dolodol?

The most common side effects of Dolodol include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Dolodol together?

Yes, acetaminophen and Dolodol can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Dolodol?

Signs of an overdose of Dolodol include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Dolodol be used for back pain?

Yes, Dolodol is often prescribed for the treatment of back pain.

Is Dolodol addictive?

Yes, Dolodol can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Dolodol?

If you forget to take a dose of Dolodol, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Dolodol be taken with alcohol?

No, Dolodol should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Dolodol?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Dolodol safe for long-term use?

Dolodol is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Dolodol be taken during pregnancy?

Dolodol should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Dolodol if I have a history of drug abuse?

No, Dolodol should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Dolodol show up on a drug test?

Yes, Dolodol may show up on a drug test, though the results may vary depending on the type of test.

Can I take Dolodol if I have liver or kidney disease?

Dolodol should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Dolodol with anti-anxiety medications?

No, Dolodol should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Dolodol?

If you experience any side effects from Dolodol, contact your doctor as soon as possible.

What other pain relievers can be taken with Dolodol?

Dolodol can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Dolodol?

The maximum daily dose of Dolodol is 400 milligrams per day for adults.

Does Dolodol cause constipation?

Yes, constipation is a common side effect of Dolodol.

Can I take Dolodol and Dolodol Plus together?

No, Dolodol and Dolodol Plus should not be taken together as it may increase the risk of adverse reactions.

Can Dolodol be taken for headaches?

Yes, Dolodol is often prescribed for the treatment of headaches.

Is Dolodol ever prescribed for arthritis?

Yes, Dolodol is sometimes prescribed for the treatment of arthritis.

Does Dolodol interact with other medications?

Yes, Dolodol may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Dolodol.

Can Dolodol be taken for menstrual cramps?

Yes, Dolodol can be prescribed for the treatment of menstrual cramps.

Can Dolodol be crushed for easier swallowing?

No, Dolodol should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Dolodol be used to treat?

Dolodol may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Dolodol while breastfeeding?

No, Dolodol should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Dolodol be taken with anti-depressants?

Yes, Dolodol can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Dolodol be taken with vitamins or supplements?

Yes, Dolodol can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Dolodol.

Can Dolodol be taken with antihistamines?

Yes, Dolodol can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Dolodol with other pain relievers?

No, Dolodol should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Dolodol metabolized by the liver?

Yes, Dolodol is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Dolodol.

How long will Dolodol stay in my system?

Dolodol can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Dolodol?

If you miss a dose of Dolodol, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Dolodol while taking other medications?

Yes, Dolodol can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Dolodol.

Does Dolodol affect blood pressure?

Yes, Dolodol may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Dolodol HCL?

Dolodol HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Dolodol?

The withdrawal symptoms of Dolodol may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Dolodol cause hallucinations?

Yes, Dolodol can cause hallucinations, especially at higher doses.

Is Dolodol the same as Vicodin?

No, Dolodol and Vicodin are different medications. Dolodol is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Dolodol be taken with other medications for pain?

Yes, Dolodol can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Dolodol.