Dithroderm

Dithroderm Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dithroderm is a brand name. Its generic name is Anthralin.

Introduction

Dithroderm (also known as dithranol) is a topical therapy used to treat psoriasis of the skin, scalp, and nails. It is also used to treat a variety of other skin conditions including eczema, lichen planus, and alopecia areata. The active ingredient in anthralin is derived from the bark of the araroba tree, which is native to South America. Dithroderm was first used in the 1950s to treat a variety of skin conditions, and it has become a commonly used treatment for psoriasis in recent years.

Uses

Dithroderm is used to treat a variety of skin conditions, such as psoriasis, eczema, and alopecia areata. It can be used on the skin, scalp, and nails. It is also used to treat lichen planus.

Mechanism of Action

Dithroderm works by promoting the shedding of dead skin cells. It also decreases inflammation, making psoriasis lesions appear less red and scaly. It helps the skin regenerate and return to its normal state by preventing the buildup of new cells.

How Long Does it Take to Work?

Dithroderm typically takes a few weeks to start working. It may take up to three months for some patients to see the full effects of anthralin therapy.

Absorption

When applied topically, anthralin is absorbed through the skin and into the bloodstream. The amount of anthralin absorbed into the bloodstream can vary depending on the concentration of the medication, the amount applied, and the area of skin in which it is applied.

Route of Elimination

After it is absorbed into the bloodstream, anthralin is eliminated from the body through the liver and kidneys.

Dosage

The dosage of anthralin depends on the severity of the condition being treated, as well as the patient’s age and weight. The generally recommended starting dose is 0.25 to 0.5 percent anthralin cream or solution applied to the affected area once to twice a day. The concentration may be increased gradually, up to a maximum of 4 percent.

Administration

Dithroderm should be applied directly to the affected areas of skin, scalp, or nails. It is important to avoid contact with the eyes and mouth, as it may cause irritation.

Side Effects

The most common side effects of anthralin include skin irritation, burning, and itching. Other side effects may include redness, peeling, and dryness of the skin.

Toxicity

Dithroderm is generally considered safe and has low potential for toxicity. However, it is important to use it as directed by a healthcare provider to reduce the risk of side effects.

Precautions

Dithroderm should not be used in people with known hypersensitivity to any of the ingredients in the formulation. It is also important to avoid getting the product in your eyes or mouth, as it may cause irritation.

Interaction

Dithroderm may interact with other topical medications, such as topical steroids. It is important to tell your healthcare provider about all medications, vitamins, and supplements you are taking before using anthralin.

Disease Interaction

People with certain medical conditions should talk to their doctor before using anthralin. These include people with kidney disease, liver disease, active tuberculosis, and diabetes.

Drug Interaction

Dithroderm may interact with other medications, such as topical steroids. It is important to tell your healthcare provider about all medications, vitamins, and supplements you are taking before using anthralin.

Food Interactions

No food interactions have been reported with anthralin.

Pregnancy Use

Dithroderm is not recommended for use during pregnancy. It is important to tell your healthcare provider if you are pregnant or breastfeeding before using this medication.

Lactation Use

Dithroderm is not recommended for use while breastfeeding. It is important to tell your healthcare provider if you are breastfeeding before using this medication.

Acute Overdose

No cases of acute overdose with anthralin have been reported.

Contraindication

Dithroderm should not be used in people with known hypersensitivity to any of the ingredients in the formulation.

Use Directions

Dithroderm should only be applied to the affected areas of skin, scalp, or nails. Avoid contact with the eyes, nose, and mouth. It should be applied once or twice daily and the affected areas may be covered with a bandage.

Storage Conditions

Dithroderm should be stored at room temperature, away from direct light. It should not be exposed to freezing temperatures.

Volume of Distribution

The volume of distribution of anthralin is unknown.

Half Life

The half-life of anthralin is unknown.

Clearance

The clearance of anthralin is unknown.

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