Dispartes Plus

Dispartes Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dispartes Plus is a brand name. Its generic name is Artemether + Lumefantrine.

What is Dispartes Plus?

Dispartes Plus (also known as Coartem or artemether + lumefantrine combination) is a combination medication used to treat malaria. It is a fixed-dose combination of two drugs, artemether (an antimalarial drug) and lumefantrine (a lipophilic allylamine).

Uses For Dispartes Plus

Dispartes Plus is used to help treat infected individuals with malaria and to reduce the spread of malaria in areas with a high infection rate. It may also be used to help treat recurrent acute attacks of malaria and lessen the severity of symptoms.

Mechanism of Action

Dispartes Plus works by interfering with the DNA of the Plasmodium parasite and blocking its growth. Artemether affects the building of the parasite's cell membrane and lumefantrine stops the spread of the parasites.

How Long Does it Take to Work?

Dispartes Plus starts to take effect within 2 days. However, it may take up to 2 weeks to clear the infection and up to 4 weeks for full recovery.

Absorption

Dispartes Plus is rapidly and almost completely absorbed from the gastrointestinal tract.

Route of Elimination

Dispartes Plus is primarily eliminated by the kidneys, although it may also be eliminated through bile or feces.

Dosage

The recommended dose for Dispartes Plus is 4 tablets twice daily, with food, for 3 days.

Administration

Dispartes Plus should be taken with food for maximum effectiveness.

Side Effects

The most common side effects of Dispartes Plus include nausea, abdominal pain, vomiting, and diarrhea. Other side effects may include anorexia, dizziness, headache, drowsiness, rash, pruritus, and insomnia.

Toxicity

The toxicity of Dispartes Plus is low. There have been reports of adverse events related to taking the combination medication, such as nausea, vomiting, and abdominal discomfort.

Precaution

Patients should inform their healthcare provider of any history of liver or kidney diseases, allergies, or other medical conditions before taking Dispartes Plus.

Interaction

Dispartes Plus may interact with other medications, including antacids, barbiturates, anticoagulants, penicillins, and phenytoin.

Disease Interaction

Dispartes Plus is not recommended for use in patients with severe renal impairment.

Drug Interaction

Dispartes Plus may interact with certain drugs, including cimetidine, ranitidine, phenobarbital, and rifabutin.

Food Interactions

Food may decrease the absorption of Dispartes Plus. It is best taken with food.

Pregnancy Use

Dispartes Plus may be used during pregnancy.

Lactation Use

Dispartes Plus is not recommended for use in breastfeeding women.

Acute Overdose

If an overdose occurs, it is important to seek medical attention immediately. Symptoms of an acute overdose may include nausea, vomiting, and abdominal pain.

Contraindication

Dispartes Plus is contraindicated in patients with a known hypersensitivity to any components of the medication.

Use Direction

Dispartes Plus should be taken as prescribed by a healthcare provider.

Storage Conditions

Dispartes Plus should be stored at room temperature in a cool, dry place.

Volume of Distribution

The volume of distribution of Dispartes Plus is estimated to be 0.91 L.

Half-Life

The estimated half-life of Dispartes Plus is 11 - 14 hours.

Clearance

The estimated clearance of Dispartes Plus is 0.28 L/hr.

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Some Frequently Asked Questions About Dispartes Plus

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What is Dispartes Plus?

Dispartes Plus is a combination anti-malaria treatment drug. It contains artemether, an antagonist of cholera and lumefantrine, a drug that blocks the malaria parasite.

How does Dispartes Plus work?

Dispartes Plus works by blocking the malaria parasite in two different ways. Artemether interferes with the enzymes of the parasite which in turn limits the ability of the parasite to multiply and spread in the body. Lumefantrine blocks the malaria parasite's ability to process hemoglobin from red blood cells, which further increases the parasite's vulnerability to artemether.

What are the benefits of using Dispartes Plus?

Dispartes Plus has been used effectively to treat and prevent malaria infections, which can be very dangerous. It is fast-acting and can help reduce the risk of death associated with malaria. Additionally, it is up to 94% effective in treating uncomplicated malaria.

Who should take Dispartes Plus?

Dispartes Plus is recommended for adults and children aged three months and older who have uncomplicated malaria. It is also recommended for people living in malaria-endemic areas who need protection against the disease.

What should I do if I miss a dose of Dispartes Plus?

If you miss a dose, take it as soon as possible. If it is within four hours of the next scheduled dose, skip the missed dose and take the next one as normal. If it is more than four hours late, take the missed dose immediately and continue with normal dosing afterwards.

Are there any possible side effects of taking Dispartes Plus?

Yes, some side effects may occur while taking Dispartes Plus, including nausea, vomiting, diarrhea, and head and muscle aches. If any of these side effects become severe or persist, talk to your doctor right away.

What should I do if I experience an allergic reaction to Dispartes Plus?

If you experience any signs of an allergic reaction, such as hives, swelling, dizziness, or difficulty breathing, seek medical attention as soon as possible.

What should I tell my doctor before taking Dispartes Plus?

Tell your doctor about any other medications you are taking, any allergies you have, and any other medical conditions you have. Also tell your doctor if you are pregnant or breastfeeding.

Can I take other medications while taking Dispartes Plus?

You should always consult your doctor or pharmacist before taking any other medication while taking Dispartes Plus. Some medications may interact with this drug, potentially increasing the risk of side effects or reducing its effectiveness.

How long does it take for Dispartes Plus to work?

The effects of Dispartes Plus start within the first day of treatment. It usually takes one to two days to reach its full effect.

Can Dispartes Plus be used to prevent malaria?

Yes, Dispartes Plus can be used to prevent malaria in people who live in malaria-endemic areas or are travelling to such areas.

Is Dispartes Plus safe for children?

Yes, Dispartes Plus is considered safe for children aged three months or older who have uncomplicated malaria. It is not recommended for children younger than three months.

Can I take vitamin supplements while taking Dispartes Plus?

Yes, you can take vitamin supplements while taking Dispartes Plus. However, it is best to consult your doctor first to check for any possible interactions with the drug.

Are there foods I should avoid while taking Dispartes Plus?

You should avoid eating grapefruits or drinking grapefruit juice while taking Dispartes Plus, as this may increase the risk of side effects or reduce the drug's effectiveness.

Can I drink alcohol while taking Dispartes Plus?

It is not recommended to drink alcohol while taking Dispartes Plus, as it may potentially increase the risk of side effects. If you do drink alcohol, make sure to drink in moderation and consult your doctor if you experience any side effects.

Can I take Dispartes Plus if I have kidney disease?

Yes, Dispartes Plus can be taken safely by people with kidney disease. However, if you have kidney disease, tell your doctor before starting treatment.

Can I take Dispartes Plus while pregnant or breastfeeding?

If you are pregnant or breastfeeding, it is best to talk to your doctor before taking Dispartes Plus. This drug should be used with caution in pregnant women due to the possible risk of side effects to the unborn child. For nursing mothers, the drug is generally considered safe, however, it is best to talk to your doctor before taking it.

Can I take Dispartes Plus before or after surgery?

It is best to talk to your doctor before taking Dispartes Plus before or after surgery. This drug may increase the risk of bleeding during surgery or interfere with other medications you may be given before surgery.

What should I do if I experience any unusual symptoms while taking Dispartes Plus?

If you experience any unusual symptoms, such as weakness, confusion, vision changes, or difficulty breathing, while taking Dispartes Plus, seek medical attention right away. These can be signs of a life-threatening allergic reaction called anaphylaxis.

Does Dispartes Plus interact with any foods?

Yes, Dispartes Plus may interact with grapefruits and grapefruit juice, which could potentially increase the risk of side effects or reduce the effectiveness of the drug.

Can I take Dispartes Plus with other anti-malaria drugs?

No, Dispartes Plus should not be taken with any other anti-malaria drugs. Taking multiple anti-malaria drugs increases the risk of side effects and reduces the effectiveness of the drug.

Can I take Dispartes Plus if I have liver disease?

Yes, Dispartes Plus can be taken safely by people with liver disease. However, if you have liver disease, tell your doctor before starting treatment.

How often should I take Dispartes Plus?

Dispartes Plus should be taken twice daily for three consecutive days. The doses should be taken 12 hours apart and should be taken with food or a fatty meal to ensure optimal absorption.

Is Dispartes Plus the same as chloroquine?

No, Dispartes Plus is not the same as chloroquine. Chloroquine is an older anti-malarial drug that is not as effective in treating and preventing certain malaria strains as Dispartes Plus.

Can I take Dispartes Plus if I'm taking birth control pills?

Yes, Dispartes Plus can be taken safely with birth control pills. However, it is best to consult your doctor first to check for any possible interactions with the drug.

Can I take Dispartes Plus while breastfeeding?

Yes, you can take Dispartes Plus while breastfeeding. However, it is best to talk to your doctor before taking it as it can pass into breast milk.

Is Dispartes Plus safe for long-term use?

Yes, Dispartes Plus is generally considered safe for long-term use. However, it is best to consult your doctor before extending your course of treatment.

Can Dispartes Plus be used to treat other forms of malaria?

Yes, Dispartes Plus can be used to treat other forms of malaria, including severe and uncomplicated malaria.

Can Dispartes Plus be used to prevent malaria?

Yes, Dispartes Plus can be used to prevent malaria in people who live in malaria-endemic areas or are travelling to such areas.

What should I do if I experience any side effects while taking Dispartes Plus?

If you experience any side effects while taking Dispartes Plus, such as nausea, vomiting, diarrhea, or dizziness, contact your doctor right away. If you experience severe side effects, seek medical attention immediately.

Does Dispartes Plus interact with any other medications?

Yes, Dispartes Plus may interact with other medications, such as warfarin, antacids, and antibiotics. It is best to consult your doctor or pharmacist before taking any other medication while taking Dispartes Plus.

What is the appropriate dosage of Dispartes Plus?

The recommended dose of Dispartes Plus is based on the age and weight of the patient. The dose for adults and children aged 15 years or older is 4 tablets taken twice daily for three days. The dose for children aged three months to 14 years is based on the child's weight and should be taken twice daily for three days. Consult your doctor for more information on the correct dosage for you or your child.

Can Dispartes Plus be used to treat pregnant women with malaria?

Yes, Dispartes Plus can be used to treat pregnant women with malaria. However, it should only be used with caution and under the supervision of a doctor, as there is a risk of side effects to the unborn child.

Can I take Dispartes Plus if I have an allergy to sulfa drugs?

No, you should not take Dispartes Plus if you have an allergy to sulfa drugs, as this medication contains a sulfonamide antibiotic. Talk to your doctor about other medications that can be taken safely instead.

Can I take Dispartes Plus if I am taking other medications?

Yes, you can take Dispartes Plus while taking other medications. However, it is best to consult your doctor or pharmacist first to check for any possible interactions with the drug.

Is it safe to take Dispartes Plus if I have an irregular heart rate?

Yes, it is generally considered safe to take Dispartes Plus if you have an irregular heart rate. However, it is best to talk to your doctor before taking the medication, as it may interact with other drugs that can affect the heart rate.

Can Dispartes Plus be used for long-term prevention of malaria?

Yes, Dispartes Plus can be used for long-term prevention of malaria in people who live in malaria-endemic areas or are travelling to such areas. However, it is best to consult your doctor before starting long-term treatment.

Can Dispartes Plus be taken with food or a drink?

Yes, Dispartes Plus can be taken with food or a drink. However, it is best to take it with a fatty meal, such as dairy products, in order to aid in the absorption of the drug.