Diflam
Diflam Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Diflam is a brand name. Its generic name is Kalium Diklofenak.
Diflam Introduction
Kalium diklofenak is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for the treatment of pain and inflammation in a variety of conditions. It belongs to the family of related drugs called phenylacetic acids. It acts by inhibiting the enzyme cyclooxygenase (COX) which is responsible for the synthesis of prostaglandins, which are mediators of inflammation, fever, and pain.Uses for Diflam
Kalium diklofenak is used to treat pain, inflammation and swelling in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, bursitis, tendinitis, dental pain, sprains, strains, menstrual cramps, back pain, headache, migraine, and other musculoskeletal pain. It is also indicated for the relief of acute gout symptoms and can be used to reduce fever.Mechanism of Action
The mechanism of action of Kalium diklofenak is inhibition of the enzyme cyclooxygenase (COX), which is responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, fever, and pain, and thus inhibition of their synthesis leads to reduced inflammation, fever, and pain.How Long Does it Take to Work?
Kalium diklofenak usually begins to work within an hour of taking it but it may take longer for some people. Pain relief may not be immediate, and it may take several days to reach its full effect.Absorption, Route of Elimination, Dosage, Administration, Side Effects, Toxicity, and Precaution
Kalium diklofenak is rapidly absorbed from the gastrointestinal tract following oral administration. It is metabolized by the liver and then eliminated primarily via the kidneys. It is generally well tolerated but may cause GI irritation, abdominal pain, nausea and diarrhea. It should be taken with food to reduce GI side effects. The recommended dose of Kalium diklofenak is 75-150 mg/day, divided into two to three doses in adults. In pediatric patients three doses of 25-50 mg/ day may be given, depending on the age. The maximum daily dose should not exceed 150 mg/day. Common side effects of Kalium diklofenak include abdominal pain, diarrhea, nausea, and vomiting. It can also cause allergic reactions, including skin rashes, itching, and anaphylaxis. More serious side effects may include anemia, bleeding, renal failure, and liver injury. Kalium diklofenak is generally safe and well tolerated when taken at the recommended dosage. However, its use should be avoided in patients with a history of allergic reactions to NSAIDs or other drugs, kidney or liver disease, active GI bleeding, or peptic ulcer disease.Interaction, Disease Interaction, Drug Interaction, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose, Contraindication, and Use Direction
Kalium diklofenak should not be taken with other NSAIDs, corticosteroids, or anticoagulants due to increased risk of GI bleeding. It may also interact with other drugs, including aspirin, antacids, diuretics, lithium, methotrexate, and warfarin. Kalium diklofenak should be avoided in pregnant and lactating women. It is not recommended for use in children under 12 years of age. In case of an acute overdose, treatment includes supportive measures and gastric lavage. There is no specific antidote for Kalium diklofenak overdose.Storage Condition, Volume of Distribution, Half Life, Clearance
Kalium diklofenak should be stored at room temperature, away from light and moisture. The volume of distribution is 0.2-0.9 L/kg. The half-life of Kalium diklofenak is approximately 4-6 hours. Its clearance ranges from 1.3 to 4.2 mL/min/kg.Here you find in details version of Diflam