Detemir
Detemir Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Detemir is a brand name. Its generic name is Insulin Detemir.
Introduction
Detemir is an insulin analog that is used as a long-acting insulin for adults and children with diabetes mellitus. It has a "tail" attached to it that binds to body tissues and slows the absorption and action of insulin. This helps it to provide more even levels of blood glucose control for up to 24 hours.Uses for
Detemir is used to lower blood glucose in people who have type 1 diabetes (diabetes mellitus) and to help control blood glucose levels in people who have type 2 diabetes. It is usually used together with a short-acting insulin that is taken before meals.Mechanism of Action
Detemir works by stimulating the uptake of glucose into cells, increasing the production of glycogen, and inhibiting the production of glucose by the liver. It also helps to reduce ketoacidosis (high levels of ketones in the blood due to an insufficiency of insulin).How Long Does It Take To Work
Detemir typically begins to work after 30 minutes and can be effective for up to 24 hours.Absorption
Detemir is slowly absorbed by the body, with peak levels typically occurring between 6 and 8 hours after administration.Route of Elimination
Detemir is eliminated from the body by renal excretion and metabolism in the liver.Dosage
Dosage of Detemir is individualized and based on the needs and response of the patient. The usual starting dose for adults with type 1 diabetes is 8–16 U per day. The dosage should be adjusted according to the patient's blood glucose levels, usually every five to 10 days.Administration
Detemir can be taken either subcutaneously by injection or by an insulin pump.Side Effects
Common side effects of Detemir include hypoglycemia (low blood sugar), weight gain, headaches, nausea, and injection site reactions.Toxicity
Detemir is considered to be well tolerated, however high doses may lead to hypoglycemia (low blood sugars).Precautions
Patients taking Detemir should monitor their blood glucose levels regularly and follow instructions for proper injection techniques. Additionally, patients should monitor for side effects such as hypoglycemia, weight gain, or injection site reactions.Interaction
Detemir may interact with certain medications (such as barbiturates, beta-blockers, diuretics, and oral antidiabetics) or alcohol. Therefore it is important to tell your doctor about any medications or supplements you are taking before starting Detemir.Disease Interaction
Detemir should not be used in patients with type 1 diabetes mellitus who are at risk for ketoacidosis, as well as in patients with unstable or severe renal or hepatic impairment.Drug Interaction
Drugs that can interact with Detemir include barbiturates, beta-blockers, diuretics, and oral antidiabetic agents.Food Interactions
Foods that can interact with Detemir include those that are high in sugar, particularly simple sugars such as candy, fruit juices, soda, and baked goods.Pregnancy Use
Detemir is not recommended for use in pregnant women unless clearly needed. Women who are pregnant or planning to become pregnant should discuss the benefits and risks of taking Detemir with their doctor.Lactation Use
Detemir should be used with caution in breastfeeding mothers. Before taking it, women should discuss any potential risks with their doctor.Acute Overdose
Overdose of Detemir can cause hypoglycemia (low blood sugar) and seizures. Treatment of overdose should include the administration of sugar or glucose and close monitoring of the patient’s blood glucose levels.Contraindication
Detemir is contraindicated in patients who have had an allergic reaction to it or any of its ingredients, as well as those with type 1 diabetes mellitus who are at risk for ketoacidosis.Use Direction
Detemir should be taken as prescribed by your doctor. It should not be taken without the supervision of a healthcare provider.Storage Condition
Detemir should be stored in the refrigerator between 2-8°C (36-46°F). It should be protected from light and should not be frozen.Volume of Distribution
The volume of distribution for Detemir is 79.2 L.Half Life
The half life of Detemir is 23.3 hours.Clearance
The clearance of Detemir is 200 mL/min.Here you find in details version of Detemir
Some Frequently Asked Questions About Detemir
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=139825,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL2104391,
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001090,
http://www.pharmgkb.org/drug/PA164746470,
http://www.rxlist.com/levemir-drug.htm,
https://www.drugs.com/monograph/insulin-detemir.html,
http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=lev1746.html&contentName=Levemir&contentId=435,
https://en.wikipedia.org/wiki/Insulin_detemir,