Depten Sr

Depten Sr Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Depten Sr is a brand name. Its generic name is Atenolol + Nifedipine.

Depten Sr Introduction

Depten Sr is a combination of two medications, atenolol and nifedipine, used to treat high blood pressure. Atenolol is a beta-blocker that blocks certain hormones, while nifedipine is a calcium channel blocker that prevents calcium from entering the cells. Together, these medications provide synergistic action to reduce blood pressure.

Uses for Depten Sr

Depten Sr is used to treat high blood pressure (hypertension) in adults. This combination medication may also be used to prevent heart attacks and strokes in certain high-risk patients.

Mechanism of Action

Depten Sr works by blocking certain hormones (beta-blockers) and preventing calcium from entering the cells (calcium channel blockers). These two medications work together to reduce overall blood pressure.

How Long Does It Take To Work?

Depten Sr can take up to two weeks to become fully effective, though most people begin to see a decrease in their blood pressure within a few days of starting the medication.

Absorption

Depten Sr is rapidly absorbed after oral administration, with peak blood concentrations reached 1 to 4 hours after dosing.

Route of Elimination

Depten Sr is metabolised in the liver and excreted in the urine.

Dosage

The standard starting dose for Depten Sr is one tablet taken once daily. Your doctor may adjust your dose depending on your response to the medication. It is important to take Depten Sr at the same time every day and to not stop taking it suddenly.

Administration

Depten Sr can be taken with or without food; with food may reduce the risk of side effects. Swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets.

Side Effects

Depten Sr can cause side effects such as dizziness, lightheadedness, fatigue, nausea, vomiting, or diarrhea. If you experience any serious side effects, such as chest pain or difficulty breathing, contact your doctor immediately.

Toxicity

Depten Sr is generally well-tolerated, but it is possible to overdose on the medication. Symptoms of overdose include sluggishness, confusion, and shallow breathing. If you suspect an overdose, seek medical attention immediately.

Precaution

Depten Sr should be used with caution in patients with kidney or liver disease, diabetes, thyroid disorders, cardiac arrest, and in those taking medications known to interact with Depten Sr.

Interaction

Depten Sr can interact with certain medications, including blood thinners, tricyclic antidepressants, and aspirin. It is important to tell your doctor about any medications you are taking before starting Depten Sr.

Disease Interaction

Depten Sr can interact with certain diseases, including diabetes, thyroid disorders, and heart failure. If you have any of these conditions, speak to your doctor before starting Depten Sr.

Drug Interaction

Depten Sr may interact with certain other medications, such as blood thinners, tricyclic antidepressants, and aspirin. It is important to tell your doctor about any medications you are taking before starting Depten Sr.

Food Interactions

Depten Sr can be taken with or without food; with food may reduce the risk of side effects.

Pregnancy Use

Depten Sr is not recommended for use during pregnancy, as it may cause harm to the fetus.

Lactation Use

Depten Sr is not recommended for use during breastfeeding as it may cause harm to the baby.

Acute Overdose

An acute overdose of Depten Sr may cause symptoms such as slowed heartbeat, confusion, and shallow breathing. If you suspect an overdose, seek medical attention immediately.

Contraindication

Depten Sr is contraindicated in patients with a known hypersensitivity or allergy to either of its components. It should also not be used by patients with a history of bradycardia, severe coronary artery disease, asthma, or COPD.

Use Direction

Depten Sr should be taken as directed by your doctor. It is important to take Depten Sr at the same time every day and to not stop taking it suddenly.

Storage Condition

Depten Sr should be stored at room temperature away from moisture, heat, and light. It should also not be stored in the bathroom.

Volume of Distribution

Depten Sr has a volume of distribution of 36.85-44.38 L/kg.

Half Life

Depten Sr has a half-life of 3-6 hours.

Clearance

Depten Sr has an average clearance of 12.50 +- 3.3 L/hr/kg.

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