Degirol
Degirol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Degirol is a brand name. Its generic name is Dequalinium.
What is Degirol
Degirol is an antiseptic, which means it helps kill bacteria, fungi, and other microorganisms on the skin and mucous membranes. It is used to prevent and treat infections caused by various organisms including Gram-positive and Gram-negative bacteria, fungi, and virus. It is available in a variety of forms including topical creams or liquids, oral tablets, and intravenous solutions.
Uses of Degirol
Degirol is mainly used to treat various infections of the skin, throat, and mouth. It can also be used for the treatment of tracheal and bronchial infections, urinary tract infections, and vaginal infections. In some cases, it may also be used to treat infections of the eyes, ears, urinary tract, and gastrointestinal tract.
Mechanism of Action
Degirol works by disrupting cell membranes of bacteria and other microorganisms, allowing it to act as an antiseptic. It is also believed to interfere with the synthesis of DNA and enzymes in bacteria, thus inhibiting their growth. Additionally, it has been suggested that the drug binds to cell receptors and prevents the entry of viruses and other microorganisms into cells.
How Long Does it Take to Work?
The amount of time it takes for Degirol to start working depends on the type of infections and the severity of the infection. Generally, the drug should start to have an effect within a few days. However, it may take up to two weeks for the drug to work effectively.
Absorption
When applied on the skin, Degirol is readily absorbed. It is believed to be well-absorbed orally, with a bioavailability of approximately 40 to 50%. Studies have shown that oral administration of Degirol leads to peak plasma concentrations in 30 minutes to 1 hour and steady-state concentrations in 4 to 5 hours.
Route of Elimination
Degirol is mainly eliminated through the kidneys, with approximately 70-80% of the drug being eliminated through the urine. The rest of the drug is metabolized in the liver and then excreted through the bile.
Dosage
The dosage of Degirol will depend on the type and severity of the infection being treated. Adults should take 8 mg to 16 mg three times daily. For children, the dosage should be adjusted depending on the age and weight. For topical applications, the drug should be applied directly onto the affected area three to four times a day.
Administration
Degirol can be administered orally in the form of tablets or capsules. It can also be administered intravenously in the form of injections. For topical applications, the drug should be applied onto the affected area three to four times a day.
Side Effects
Common side effects associated with Degirol include nausea, vomiting, diarrhea, headache, dizziness, and rash. Rare side effects may include abdominal pain, anorexia, anemia, and abnormal liver function tests. In some cases, hypersensitivity reactions such as hives, wheezing, and rash may occur.
Toxicity
Degirol is generally well-tolerated and has a low toxicity. The drug is considered to be safe when taken as directed. If taken in high doses, however, it can cause impaired liver and kidney function, seizures, and coma.
Precautions
It is important to tell your doctor about any other medications or supplements you are taking before using Degirol. The drug may interact with certain medications and can cause serious side effects. Additionally, the drug should be used with caution in pregnant and breastfeeding women.
Interactions
Degirol may interact with other medications, including antibiotics, antidepressants, and antifungal drugs. It may also interact with dietary supplements, herbs, and other natural products. Always talk to your doctor before taking any new medications or supplements.
Disease Interactions
Degirol may interact with certain diseases, including kidney or liver disease, myasthenia gravis, asthma, and epilepsy. It may also interact with blood diseases, including sickle cell anemia and thalassemia, as well as with HIV/AIDS.
Drug Interactions
Degirol may interact with other drugs, including antibiotics, antifungals, anticoagulants, antipsychotics, and antivirals. It may also interact with aminoglycosides, quinolones, tetracyclines, and sulfonamides. Tell your doctor about all the medications you are taking before using Degirol.
Food Interactions
Degirol should be taken according to the instructions of your doctor or pharmacist. It should not be taken with alcoholic beverages. The drug should not be taken with certain foods, such as dairy products, fruit juices, and soy.
Pregnancy Use
Degirol is classified as a pregnancy Category C drug. This means that it should be used with caution in pregnant women. It is not known whether the drug is safe for use in pregnancy, so pregnant women should consult their doctors before using the drug.
Lactation Use
It is not known whether Degirol is secreted into breastmilk. Therefore, it is recommended that breastfeeding women should take the drug with caution. It is advisable to consult a doctor before taking the drug while breastfeeding.
Acute Overdose
An acute overdose of Degirol can lead to serious side effects, including convulsions, seizures, and coma. If you or someone you know has taken an overdose of the drug, seek medical attention immediately.
Contraindications
Degirol is contraindicated in patients with a known history of hypersensitivity to the drug. It is also contraindicated in patients with glaucoma, heart block, and certain liver or kidney diseases.
Usage Directions
Degirol should be used according to the instructions of your doctor or pharmacist. Follow all directions on the label and/or prescription package carefully. If you have any questions, talk to your doctor or pharmacist before taking the medication.
Storage Condition
Degirol should be stored at room temperature, away from direct sunlight and heat. Keep the medication out of reach of children. Do not store the drug for longer than recommended.
Volume of Distribution
The volume of distribution of Degirol is approximately 11.7 L/kg. It is distributed in the body tissues with the highest concentrations found in the skin, lungs, and gums.
Half Life
The half-life of Degirol is approximately 5.5 hours. This is the amount of time it takes for the drug to be reduced by half its initial concentration in the body.
Clearance
The clearance of Degirol is approximately 4.8 mL/min/kg. This is the amount of drug that is eliminated from the body in a given time frame.
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