Dalium
Dalium Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dalium is a brand name. Its generic name is Desvenlafaxine.
Introduction
Dalium, also known by its brand name Pristiq, is an antidepressant medication used to treat major depressive disorder (MDD). It is a serotonin-norepinephrine reuptake inhibitor (SNRI). It belongs to the same class of medications as venlafaxine (Effexor) and duloxetine (Cymbalta).Uses For
Dalium is used to treat adults with major depressive disorder (MDD). It is also used to treat generalized anxiety disorder (GAD), panic disorder, post-traumatic stress disorder (PTSD), and social anxiety disorder.Mechanism of Action
The exact mechanism of action of desvenlafaxine is not known. It is thought to work by increasing the amount of serotonin and norepinephrine in the brain, which are two neurotransmitters that are associated with feelings of wellbeing and mood balance.How Long Does It Take to Work?
Dalium usually starts to work within one to three weeks. It can take six weeks or longer before its full effects are felt. The response to treatment may vary from patient to patient.Absorption
Dalium is rapidly absorbed after oral administration with peak concentrations occurring within 1-2 hours. It is highly bioavailable with an absolute oral bioavailability of approximately 70%.Route of Elimination
Dalium is primarily metabolized in the liver by the cytochrome P450 isoenzyme CYP2D6 and to a lesser extent by CYP2C19 and CYP3A4. It is eliminated by the kidneys in unchanged form and as metabolites.Dosage
Dalium is available as an extended-release tablet taken by mouth once daily. The usual starting dose is 50 mg once daily. This drug may be increased up to 100 mg daily, depending on the patient’s response.Administration
Dalium should be taken by mouth once daily with or without food. The tablet can be swallowed whole or dissolved in water to form a suspension for easier ingestion if needed.Side Effect
Dalium may cause side effects such as nausea, vomiting, constipation, dry mouth, insomnia, headache, dizziness, and drowsiness. If these side effects do not go away or become bothersome, contact your doctor for advice.Toxicity
Dalium has low toxicity and is unlikely to cause serious adverse effects. Severe to life-threatening reactions have been reported but typically only occur in the setting of overdose.Precaution
Patients should be monitored for underlying medical conditions, particularly depression and suicidal thoughts. Patients should be monitored for changes in behavior, especially during the first few months of treatment.Interaction
Dalium can interact with certain medications (e.g. antidepressants, heart medications, blood thinners, etc.). It can also interact with certain foods and beverages (e.g. alcohol, grapefruit juice, etc.). Patients should discuss all potential drug and food interactions with their doctor prior to taking desvenlafaxine.Disease Interaction
Dalium may interact with certain diseases, such as bipolar disorder, glaucoma, liver disease, and kidney disease. Patients should discuss any known disease interactions with their doctor prior to taking desvenlafaxine.Drug Interaction
Dalium may interact with certain drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants, and antiarrhythmics. Patients should discuss all potential drug interactions with their doctor prior to taking desvenlafaxine.Food Interaction
Dalium may interact with certain foods and beverages, such as alcohol, grapefruit juice, and caffeine. Patients should discuss all potential food and beverage interactions with their doctor prior to taking desvenlafaxine.Pregnancy Use
Dalium should be used in pregnancy only when the benefit outweighs the risk. Patients should discuss all concerns with their doctor prior to taking desvenlafaxine.Lactation Use
Dalium is excreted in breast milk and should be avoided in nursing mothers. Patients should discuss all concerns with their doctor prior to taking desvenlafaxine.Acute Overdose
Acute overdose of desvenlafaxine can be life-threatening. Symptoms of overdose may include somnolence, confusion, coma, and seizures. If an acute overdose is suspected, immediate medical attention should be sought.Contraindication
Dalium is contraindicated in patients with hypersensitivity to the drug or any of its components. It is also contraindicated in patients with certain underlying medical conditions, such as bipolar disorder, glaucoma, liver disease, and kidney disease.Use Direction
Dalium should be taken as directed by your doctor. The usual dose is 50-100 mg taken orally once daily with or without food. Do not take more than the recommended dose.Storage Condition
Dalium should be stored at room temperature, away from moisture and heat. Do not store in the bathroom. Keep this and all medication out of the reach of children.Volume of Distribution
The volume of distribution of desvenlafaxine is approximately 42 liters/kg.Half Life
The elimination half-life of desvenlafaxine is approximately 11 hours.Clearance
The clearance of desvenlafaxine is approximately 0.95 mL/min/kg.Here you find in details version of Dalium
Some Frequently Asked Questions About Dalium
What is Dalium?
Dalium, also known as Pristiq, is an antidepressant medication that belongs to a class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the levels of certain chemicals in the brain that are responsible for regulating mood.
What is the purpose of Dalium?
Dalium is used to treat depression in adults. It works by restoring the balance of certain natural chemicals (neurotransmitters) in the brain.
How long before Dalium begins to work?
Dalium may begin to work within 1 to 4 weeks. It is important to continue taking it as prescribed by your doctor even if you do not immediately feel an improvement in your symptoms.
Is Dalium used to treat other conditions?
No, Dalium is only approved for the treatment of major depressive disorder in adults.
How should Dalium be taken?
Dalium should be taken exactly as prescribed by your doctor. It should be taken with food or milk, and at about the same time each day. The tablets should not be chewed, crushed or broken open.
Is there a difference between Dalium and other antidepressants?
Yes, Dalium belongs to a different class of antidepressants known as serotonin norepinephrine reuptake inhibitors (SNRIs). This type of medication works by restoring the balance of certain natural chemicals in the brain, and it is often prescribed when other treatments, such as selective serotonin inhibitors (SSRIs), have not been effective.
Can Dalium be taken with other medications?
Yes, Dalium can be taken with other medications, however, it is important to speak to your doctor or pharmacist before combining Dalium with any other medications.
What are the side effects of Dalium?
The most common side effects of Dalium include insomnia, nausea, dry mouth, headache, constipation, dizziness, loss of appetite, increased sweating, decreased sexual desire, fatigue, and drowsiness.
What should I do if I experience any side effects?
If you experience any of the side effects listed above, you should contact your doctor or pharmacist. Your doctor or pharmacist can help you manage the side effects and may be able to recommend ways to reduce or prevent them.
Are there any risks associated with taking Dalium?
Yes, as with all medications, there are risks associated with taking Dalium. Some of these include an increased risk of suicidal thoughts, especially in young adults, as well as an increased risk for serotonin syndrome (a serious condition caused by the body having too much serotonin). It is important to discuss any risks with your doctor before taking Dalium.
What should I do if I miss a dose?
If you miss a dose of Dalium, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the missed dose and take your next dose at the regular time. You should not take two doses at once.
What should I do if I overdose on Dalium?
If you believe that you have taken too much Dalium, you should contact your local poison control center or seek emergency medical attention right away. An overdose of Dalium can be fatal.
Are there any interactions between Dalium and other medications?
Yes, Dalium can interact with other medications and can cause serious side effects. It is important to tell your doctor about all medications and supplements that you are taking before starting Dalium. Your doctor can help you determine if any of your medications could potentially interact with Dalium.
Is Dalium addictive?
No, Dalium is not addictive. However, as with all medications, it is important to take it as prescribed by your doctor. If you experience any withdrawal symptoms when stopping Dalium, you should contact your doctor immediately.
Can Dalium cause weight gain?
Yes, Dalium can cause weight gain. However, this is not always the case, as some people may even experience weight loss. It is important to speak to your doctor if you experience any changes in your weight while taking this medication.
Can Dalium be used while pregnant?
It is generally not recommended to take Dalium during pregnancy unless it is clearly necessary. If you are pregnant and are considering taking Dalium, you should discuss the risks and benefits of the medication with your doctor.
Can Dalium be used while breastfeeding?
Dalium has been found to be present in human breast milk. Therefore, it is generally not recommended to take Dalium while breastfeeding. You should discuss the risks and benefits of the medication with your doctor if you are considering taking it while breastfeeding.
Can I drink alcohol while taking Dalium?
It is not recommended to drink alcohol while taking Dalium as this may increase the risk of adverse side effects. If you choose to drink alcohol, it is important to do so in moderation and only after discussing this with your doctor.
Does Dalium have any effect on blood pressure?
Yes, Dalium may cause a temporary increase in blood pressure. It is important to have your blood pressure checked regularly, especially if you have pre-existing hypertension.
Is it safe to take Dalium for a long period of time?
Yes, it is safe to take Dalium for a long period of time as long as you continue to monitor your symptoms and have regular follow-up appointments. However, it is important to talk to your doctor if you experience any side effects or if you do not feel that the medication is working.
Can Dalium cause liver damage?
Dalium does not typically cause liver damage. However, if you have pre-existing liver conditions, you should be closely monitored for any signs of liver damage, such as jaundice, dark urine, or abdominal pain.
Can I drive while taking Dalium?
It is generally recommended not to drive while taking Dalium as it may cause drowsiness or dizziness, which could affect your ability to drive safely. If you experience these symptoms, you should refrain from driving until the effects have passed.
Can Dalium be used for children?
Dalium is not approved for use in children. If your child is suffering from depression, you should speak to their doctor about other treatments or medications that might be suitable.
How often should I have my blood pressure checked while taking Dalium?
It is recommended to have your blood pressure checked every 3 to 6 months while taking Dalium, especially if you have pre-existing hypertension. Your doctor can determine how often your blood pressure should be checked.
Can I take Dalium if I have a history of seizures?
It is generally recommended not to take Dalium if you have a history of seizures. If you are taking any other medications that can increase your risk of seizures, you should discuss these with your doctor before taking Dalium.
Is there a generic version of Dalium available?
Yes, Dalium is available in a generic form, known as Dalium succinate. It is important to check with your pharmacist to determine if a generic version of your medication is available and if it is right for you.
What is the recommended dose of Dalium?
The recommended dose of Dalium is 50mg per day. Your doctor may start you at a lower dose and gradually increase the dose to minimize the risk of side effects. It is important to discuss your individual dose with your doctor.
Are there any lab tests that I should get while taking Dalium?
Your doctor may order some laboratory tests while you are taking Dalium. These may include complete blood count (CBC), kidney function tests, and liver function tests. Having these tests done will help your doctor monitor your progress and adjust the dose of the medication if needed.
Does Dalium cause withdrawal symptoms?
Yes, if Dalium is abruptly stopped, you may experience withdrawal symptoms such as anxiety, dizziness, headache, nausea, and sleep disturbances. It is important to follow your doctor's instructions when discontinuing this medication and to talk to your doctor if you experience any of these symptoms.
Are there any alternatives to Dalium?
Yes, there are several alternatives to Dalium, such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and monoamine oxidase inhibitors (MAOIs). Talk to your doctor to determine which medication may be right for you.
Is Dalium associated with any risks for the elderly?
Yes, elderly patients may be more prone to certain side effects of Dalium, such as increased blood pressure, falls, confusion, and cognitive impairment. It is important to have regular follow-up visits with your doctor if you are taking Dalium and are over the age of 65.
What are the symptoms of an allergic reaction to Dalium?
Symptoms of an allergic reaction to Dalium may include hives, difficulty breathing, swelling of the face, lips, tongue or throat, and itching or rash. If you experience any of these symptoms, you should seek emergency medical attention right away.
Does Dalium interact with grapefruit?
Yes, Dalium can interact with grapefruit. It is important to avoid consuming grapefruit or grapefruit juice while taking Dalium as this can increase the risk of side effects.
Does Dalium require refrigeration?
No, Dalium does not require refrigeration. It should be stored at room temperature between 59-86°F (15-30°C). It is important to keep the medication away from moisture and direct light.
Is Dalium available in different forms?
Yes, Dalium is available as tablets, extended release tablets, and oral suspension. Talk to your doctor or pharmacist to determine which form of the medication would be best for you.
Can Dalium be taken with food?
Yes, Dalium can be taken with food or milk. Taking the medication with food may help reduce stomach upset. However, it is important to take Dalium at the same time each day to ensure consistent levels in the body.
Can Dalium be used for anxiety?
No, Dalium is not approved for the treatment of anxiety. However, some people may experience improvements in anxiety symptoms while taking Dalium for depression. If your doctor has prescribed it for this purpose, it is important to discuss any changes in symptoms with your doctor.