Coromax
Coromax Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Coromax is a brand name. Its generic name is Eptifibatide.
Introduction
Coromax is a cyclic heptapeptide used to prevent thrombosis (formation of blood clots) in patients with unstable angina or coronary artery disease. It is often referred to as a glycoprotein IIb/IIIa inhibitor.
Uses for
Coromax is used to prevent thrombosis (blood clots) in patients with unstable angina or coronary artery disease. It is also used to treat additional cardiac disorders such as myocardial infarction (heart attack).
Mechanism of Action
Coromax works by blocking the platelet glycoprotein IIb / IIIa receptor, preventing the binding of fibrinogen to platelets, and thus blocking the formation of a thrombus.
How Long Does it take to Work?
Coromax usually starts to work within 20 minutes of administration. The full therapeutic effect of Coromax can be accomplished in as little as an hour.
Absorption
Coromax is rapidly absorbed after intravenous administration and its bioavailability is approximately 100%.
Route of Elimination
Coromax is eliminated from the body primarily by the kidneys.
Dosage
The standard recommended dose of Coromax is 180 µg/Kg (maximum of 18 mg) administered by intravenous infusion over 10 minutes. The infusion should be repeated with 90 µg/Kg (maximum of 9 mg) over one hour, followed by an additional infusion of 0.75 µg/Kg/minute (maximum of 7.5 mg per hour) as required.
Administration
Coromax should only be administered under the supervision of a qualified medical practitioner. It should be given as an intravenous infusion.
Side Effects
Coromax may cause side effects such as nausea, vomiting, headache, dizziness, back pain, chest pain, diarrhea, weakness, and rash. If any of these side effects are experienced, the patient should contact their physician immediately.
Toxicity
Coromax is generally well tolerated. Overdose of Coromax may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators.
Precaution
Coromax should be used with caution in patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Interaction
Coromax is known to interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Disease Interaction
Coromax may be contraindicated in certain patients with a history of bleeding disorders or any other conditions in which bleeding is a risk.
Drug Interaction
Coromax may interact with certain other drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and heparin, which may increase the risk of bleeding.
Food Interactions
Coromax is known to interact with certain foods, such as grapefruit juice. Grapefruit juice should be avoided when taking Coromax.
Pregnancy Use
Coromax should not be used in pregnant women as safety in this population has not been established.
Lactation Use
Coromax should be used with caution in breastfeeding women as it is not known if the drug passes into breast milk.
Acute Overdose
Overdose of Coromax may cause serious hypotension, which may be treated with intravenous fluids and/or vasodilators. In cases of serious overdose, seek immediate medical attention.
Contraindication
Coromax is contraindicated in patients with a history of bleeding disorders, recent surgery, or any other conditions in which bleeding is a risk.
Use Direction
Coromax must only be administered by a qualified medical practitioner. It must be given as an intravenous infusion per the instruction of the prescribing physician.
Storage Condition
Coromax should be stored at a temperature between 20-25°C.
Volume of Distribution
The volume of distribution of Coromax is estimated as 118 liters.
Half Life
The elimination half-life of Coromax is approximately 4.07 hours.
Clearance
The clearance of Coromax is estimated as 11 liters/hour.
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