Coolora
Coolora Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Coolora is a brand name. Its generic name is Benzydamine.
Introduction
Coolora is a local anesthetic and anti-inflammatory drug used to treat conditions such as mouth ulcers, sore throat, and other inflammation and swelling of the mouth or throat. It is commercially available in a hydrochloride salt or hydrofluoride salt form, and is commonly referred to by its trade name, Difflam.
Uses
Coolora is commonly used to relieve pain and inflammation of the mouth and throat, as well as to reduce swelling in the mouth or throat. It is sometimes used to treat conditions such as canker sores, gum inflammation, and other forms of mouth ulceration or throat infection. It can also be used to reduce swelling and inflammation after dental procedures or other surgeries.
Mechanism of Action
The exact mechanism of action of benzydamine is currently unknown. It is thought to work by blocking the actions of certain inflammatory mediators, such as prostaglandins and leukotrienes, which are naturally-occurring compounds that cause inflammation. It also appears to have some anti-bacterial activity against certain oral bacteria.
How Long Does it Take to Work?
Coolora usually takes about 15 to 20 minutes to start easing the symptoms of pain and swelling, although the time may vary depending on the severity of the condition. For long-term relief, benzydamine should be used regularly as directed by your doctor or pharmacist.
Absorption
Approximately 70% of benzydamine is absorbed in the gastrointestinal tract, although the rate may be lower if the drug is taken with food or other substances. Most of the drug is metabolized by the liver, and the metabolites are then eliminated through the kidneys.
Route of Elimination
Coolora is eliminated primarily through the kidneys. The half-life of the drug is approximately 24 hours, meaning that it takes around 12 days for the drug to be eliminated from the body.
Dosage
The usual recommended adult dose of benzydamine is 15 - 30 mg, three or four times daily. The dose should be taken with food if possible, and for best results it should be taken at regular intervals. The maximum dose for adults is 60mg per day.
Administration
Coolora is administered orally, usually in the form of either a tablet or oral liquid. The tablets can be swallowed whole with water, or the liquid can be mixed with water or other fluids. In some cases, the tablet can also be crushed and mixed with water before being administered.
Side Effect
Common side effects associated with benzydamine use include nausea, vomiting, headache, dizziness, drowsiness, increased salivation, and dry mouth. Rare side effects may include difficulty breathing and skin rashes. In some cases, benzydamine may cause allergic reactions in some individuals, so it should not be used by those who are allergic to it or any of its ingredients.
Toxicity
The typical adult toxicity of benzydamine is very low. It is generally not considered to be toxic, although very high doses have been associated with photosensitivity and anticholinergic effects.
Precautions
Since benzydamine can sometimes cause side effects, it should not be used by those with certain medical conditions, such as allergies, asthma, kidney or liver problems, or if you are pregnant or breastfeeding. It is also important to avoid using benzydamine if you are taking other medications, as they may interact with each other and cause serious side effects.
Interactions
Coolora may interact with certain other drugs, such as anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), methotrexate, and corticosteroids, so it is important to check with your doctor before taking any new medications or supplements. In addition, benzydamine should not be taken at the same time as alcohol, as this may enhance the side effects of the drug.
Disease Interaction
Coolora should not be used if you have certain medical conditions, such as kidney disease, liver disease, or a bleeding disorder. It should also be avoided if you have active ulcers, asthma, or a certain type of eye disorder known as angle-closure glaucoma.
Drug Interaction
Coolora may interact with other drugs, so it is important to check with your doctor before taking any new medications or supplements. This includes over-the-counter medications, herbal remedies, and vitamins. It is also important to avoid using alcohol or recreational drugs while taking benzydamine.
Food Interactions
Coolora is not known to interact with any foods or beverages. However, it should be taken with food if possible, as this may help to reduce the risk of side effects.
Pregnancy Use
There is limited information available about the use of benzydamine during pregnancy, so it should be avoided if possible. If it is necessary to use this drug during pregnancy, the benefits should be weighed against the potential risks.
Lactation Use
It is not known whether benzydamine is safe to use while breastfeeding. It is not recommended to take this drug while breastfeeding due to the potential for side effects, so it is best to avoid it or to discuss other options with your doctor.
Acute Overdose
Symptoms of an overdose of benzydamine may include extreme drowsiness, confusion, difficulty breathing, and heart palpitations. If an overdose is suspected, seek medical help immediately.
Contraindications
Coolora should not be used in individuals with a history of hypersensitivity to benzydamine or any of its excipients. It should also not be used in patients with active ulcers, asthma, or certain types of eye disorders.
Use Direction
Coolora should be taken as directed by your doctor or pharmacist. The tablets should be swallowed whole with water or the liquid can be mixed with water or other fluids. It is important to follow the directions on the medication label carefully and to not exceed the recommended dosage.
Storage Condition
Coolora should be stored at room temperature in a cool, dry place, out of reach of children and pets. It is also important to keep it away from heat and direct sunlight.
Volume of Distribution
The volume of distribution of benzydamine in the body is approximately 200L, indicating that it is widely distributed throughout the body.
Half Life
The half-life of benzydamine is approximately 24 hours, meaning that it takes around 12 days for the drug to be eliminated from the body.
Clearance
The clearance of benzydamine is approximately 5.8ml/min/kg, meaning that it is rapidly cleared from the body.
Here you find in details version of Coolora
Some Frequently Asked Questions About Coolora
1. What is Coolora?
Coolora is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain of the mouth and throat.
2. What is Coolora used for?
Coolora is used to reduce inflammation and pain associated with infectious and non-infectious conditions of the mouth and throat.
3. How long does it take for Coolora to work?
Coolora usually begins to work within 15 minutes of application, although the effects do not last as long as more traditional anti-inflammatory medications.
4. Are there any side-effects associated with Coolora?
Yes,common side effects of Coolora include nausea, vomiting, stinging or burning of the mouth, and a bitter taste in the mouth.
5. Can Coolora be used in children?
Yes, Coolora can be used in children aged over 6 years old, when administered in the correct dose.
6. Is Coolora safe during pregnancy?
No, Coolora is not recommended for use during pregnancy or breastfeeding.
7. Can I take Coolora with other medications?
Yes, it is generally safe to take Coolora with other medications. However, it is important to inform your doctor or pharmacist if you are taking any other medications.
8. Are there any other drugs I should avoid while taking Coolora?
Yes, you should avoid taking any anti-inflammatory drugs such as aspirin, ibuprofen, or naproxen while taking Coolora.
9. If I accidentally take too much Coolora, what should I do?
If you accidentally take too much Coolora, you should seek medical advice immediately.
10. Can I drink alcohol while taking Coolora?
No, it is advisable to avoid drinking alcohol while taking benzydamine as it may increase the risk of side effects.
11. Is Coolora available over the counter?
No, Coolora is available with a prescription from your doctor.
12. What is the usual dosage for Coolora?
The usual dose of Coolora is 1 spray every 3-4 hours. If the symptoms persist, the dose may be increased up to 2 sprays every 3-4 hours.
13. How long can I take Coolora for?
Coolora can be taken for up to 7 days, however if the symptoms persist, it is advisable to visit your doctor for further advice.
14. Is Coolora habit forming?
No, Coolora is not habit forming.
15. Are there any foods or supplements that I should avoid while taking Coolora?
No, there are no known foods or supplements that you should avoid when taking Coolora.
16. What should I do if I miss a dose of Coolora?
If you miss a dose of Coolora, you should take it as soon as you remember. If it is almost time for your next dose, it is best to skip the missed dose and take the next scheduled dose.
17. Can Coolora be used to treat gum infections?
Yes, Coolora can be used to reduce the pain and inflammation associated with gum infections.
18. Are there any drug interactions associated with Coolora?
Yes, Coolora may interact with certain drugs. It is important to inform your doctor or pharmacist if you are taking any other medication.
19. Is Coolora available in generic form?
Yes, Coolora is available in generic form.
20. Is Coolora available in a liquid form?
Yes, Coolora is available in a liquid form as well.
21. What is the difference between Coolora and Ibuprofen?
The main difference between Coolora and ibuprofen is that Coolora is a non-steroidal anti-inflammatory drug (NSAID), while ibuprofen is a non-selective NSAID. Both medications are used to reduce pain and inflammation, but Coolora is more suitable for use in the mouth and throat.
22. Can Coolora be used for toothache pain?
Yes, Coolora can be used to reduce the pain associated with toothache.
23. Can Coolora be used for sore throat?
Yes, Coolora can be used to reduce the pain and inflammation associated with sore throat.
24. Can I take Coolora with other pain relief medications?
No, you should avoid taking any other pain relief medications such as ibuprofen or aspirin while taking Coolora.
25. Are there any specific side effects of taking Coolora?
The most common side effects of taking benzydamine include nausea, vomiting, a bitter taste in the mouth and stinging/burning of the mouth.
26. Is Coolora suitable for long term use?
No, Coolora is not suitable for long term use. If the symptoms persist after taking Coolora for 7 days, it is advisable to visit your doctor for further advice.
27. Can Coolora be taken with other antibiotics?
Yes, it is generally safe to take Coolora with other antibiotics. However, it is important to inform your doctor or pharmacist if you are taking any other medications.
28. What should I do if I experience an allergic reaction to Coolora?
If you experience an allergic reaction to Coolora, you should seek medical help immediately.
29. Is Coolora available in injection form?
No, Coolora is only available in spray and liquid form.
30. How should I store Coolora?
Coolora should be stored at room temperature, away from direct heat and light. It should be kept out of the reach of children and pets.