Contramal Dt
Contramal Dt Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Contramal Dt is a brand name. Its generic name is Tramadol.
Contramal Dt
Contramal Dt, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Contramal Dt also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Contramal Dt is available in both immediate-release and extended-release forms.
Uses For Contramal Dt
Contramal Dt is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Contramal Dt is sometimes prescribed for the treatment of opioid dependence.
Mechanism Of Action
Contramal Dt works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Contramal Dt also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.
How Long Does It Take To Work?
Contramal Dt typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.
Absorption
Contramal Dt is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.
Route Of Elimination
Contramal Dt is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.
Dosage
Dosage of Contramal Dt depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.
Administration
Contramal Dt can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.
Side Effect
Common side effects of Contramal Dt include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.
Toxicity
Contramal Dt is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.
Precautions
Contramal Dt should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Contramal Dt should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.
Interaction
Contramal Dt may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.
Disease Interaction
Contramal Dt may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.
Drug Interaction
Contramal Dt can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.
Food Interactions
Contramal Dt should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.
Pregnancy Use
Contramal Dt is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.
Lactation Use
Contramal Dt should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.
Acute Overdose
Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.
Contraindication
Contramal Dt is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.
Use Direction
Contramal Dt should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.
Storage Condition
Contramal Dt should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.
Volume Of Distribution
Contramal Dt has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.
Half Life
Contramal Dt has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.
Clearance
Contramal Dt has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.
Here you find in details version of Contramal Dt
Some Frequently Asked Questions About Contramal Dt
What is Contramal Dt?
Contramal Dt is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.
What is the generic name of Contramal Dt?
Contramal Dt's generic name is Ultram.
What is the mechanism of action of Contramal Dt?
Contramal Dt works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.
Is Contramal Dt a controlled substance?
Yes, Contramal Dt is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.
How fast does Contramal Dt work?
Contramal Dt works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.
How should Contramal Dt be taken?
Contramal Dt should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.
What are the side effects of Contramal Dt?
The most common side effects of Contramal Dt include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.
Can I take acetaminophen and Contramal Dt together?
Yes, acetaminophen and Contramal Dt can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.
What are the signs of an overdose of Contramal Dt?
Signs of an overdose of Contramal Dt include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.
Can Contramal Dt be used for back pain?
Yes, Contramal Dt is often prescribed for the treatment of back pain.
Is Contramal Dt addictive?
Yes, Contramal Dt can be addictive when taken in large amounts or for long periods of time.
What should I do if I forget to take a dose of Contramal Dt?
If you forget to take a dose of Contramal Dt, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can Contramal Dt be taken with alcohol?
No, Contramal Dt should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.
Should I avoid caffeine while taking Contramal Dt?
Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.
Is Contramal Dt safe for long-term use?
Contramal Dt is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.
Can Contramal Dt be taken during pregnancy?
Contramal Dt should not be taken during pregnancy as it can cause harm to the fetus.
Can I take Contramal Dt if I have a history of drug abuse?
No, Contramal Dt should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.
Will Contramal Dt show up on a drug test?
Yes, Contramal Dt may show up on a drug test, though the results may vary depending on the type of test.
Can I take Contramal Dt if I have liver or kidney disease?
Contramal Dt should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.
Can I take Contramal Dt with anti-anxiety medications?
No, Contramal Dt should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.
What should I do if I experience any side effects from Contramal Dt?
If you experience any side effects from Contramal Dt, contact your doctor as soon as possible.
What other pain relievers can be taken with Contramal Dt?
Contramal Dt can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.
What is the maximum daily dose of Contramal Dt?
The maximum daily dose of Contramal Dt is 400 milligrams per day for adults.
Does Contramal Dt cause constipation?
Yes, constipation is a common side effect of Contramal Dt.
Can I take Contramal Dt and Contramal Dt Plus together?
No, Contramal Dt and Contramal Dt Plus should not be taken together as it may increase the risk of adverse reactions.
Can Contramal Dt be taken for headaches?
Yes, Contramal Dt is often prescribed for the treatment of headaches.
Is Contramal Dt ever prescribed for arthritis?
Yes, Contramal Dt is sometimes prescribed for the treatment of arthritis.
Does Contramal Dt interact with other medications?
Yes, Contramal Dt may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Contramal Dt.
Can Contramal Dt be taken for menstrual cramps?
Yes, Contramal Dt can be prescribed for the treatment of menstrual cramps.
Can Contramal Dt be crushed for easier swallowing?
No, Contramal Dt should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.
What other conditions can Contramal Dt be used to treat?
Contramal Dt may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.
Can I take Contramal Dt while breastfeeding?
No, Contramal Dt should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.
Can Contramal Dt be taken with anti-depressants?
Yes, Contramal Dt can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).
Can Contramal Dt be taken with vitamins or supplements?
Yes, Contramal Dt can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Contramal Dt.
Can Contramal Dt be taken with antihistamines?
Yes, Contramal Dt can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.
Can I take Contramal Dt with other pain relievers?
No, Contramal Dt should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.
Is Contramal Dt metabolized by the liver?
Yes, Contramal Dt is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Contramal Dt.
How long will Contramal Dt stay in my system?
Contramal Dt can stay in the system for up to 24 hours after the last dose.
What should I do if I miss a dose of Contramal Dt?
If you miss a dose of Contramal Dt, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can I take Contramal Dt while taking other medications?
Yes, Contramal Dt can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Contramal Dt.
Does Contramal Dt affect blood pressure?
Yes, Contramal Dt may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.
What is Contramal Dt HCL?
Contramal Dt HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.
What are the withdrawal symptoms of Contramal Dt?
The withdrawal symptoms of Contramal Dt may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.
Can Contramal Dt cause hallucinations?
Yes, Contramal Dt can cause hallucinations, especially at higher doses.
Is Contramal Dt the same as Vicodin?
No, Contramal Dt and Vicodin are different medications. Contramal Dt is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.
Can Contramal Dt be taken with other medications for pain?
Yes, Contramal Dt can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Contramal Dt.