Combair Respiratory
Combair Respiratory Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Combair Respiratory is a brand name. Its generic name is Salbutamol + Ipratropium Bromide.
Introduction
Combair Respiratory is a combination of two medications called bronchodilators. It is used as a bronchodilator for treating bronchospasm (airway spasms) and chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.Uses For
Combair Respiratory is used to treat bronchospasm, which is difficulty in breathing caused by airway narrowing. It is often used to treat acute exacerbations of COPD. It is also used in the prophylaxis of asthma attacks.Mechanism of Action
Combair Respiratory contains two bronchodilators: Salbutamol, which is a selective β2-adrenoceptor agonist and Ipratropium Bromide, which is an anticholinergic agent. Salbutamol relaxes smooth airway muscle cells while Ipratropium Bromide works by reducing the amount of bronchoconstricting mucous and reducing nerve reflexes that cause bronchoconstrictive airway narrowing.How Long Does It Take to Work?
The effects of Combair Respiratory can usually be felt within 5 minutes of taking the medication. Maximum bronchodilation can be seen after about 30 minutes after inhalation.Absorption
Combair Respiratory is rapidly and completely absorbed from the lungs. It is converted to its active metabolite Salbutamol sulfate, and Ipratropium bromide is partially metabolized.Route of Elimination
The metabolites of Combair Respiratory are mostly eliminated through the kidney. Both Salbutamol and Ipratropium bromide are eliminated unchanged in the urine.Dosage
The recommended adult dose of Combair Respiratory is one inhalation 4 times per day. The doses may be increased to two inhalations four times per day as needed. The recommended dosage for pediatric patients is one inhalation 3-4 times per day. Patients should follow the directions given by their physician.Administration
Combair Respiratory should be used with an inhaler device. Patients should shake the inhaler canister well before each use. The inhaler should be held upright into the mouth and inhaled fully.Side Effects
Some of the common side effects of Combair Respiratory include headache, dizziness, nausea, nervousness, tremor, insomnia, palpitations and chest tightness. More serious side effects can include pulmonary edema, chest pain and arrhythmia.Toxicity
The maximum recommended dose of Combair Respiratory is two inhalations four times per day. If higher doses are used, toxicity can occur due to accumulation of the medications.Precautions
Patients should be advised not to stop taking Combair Respiratory without consulting their physician, as their symptoms may worsen. It is important to use regular inhalation technique to ensure the optimal effects of the medication. Patients should also be aware of drug interactions and should inform their physician of any other medications they are taking.Interactions
Combair Respiratory may interact with other medications, including oral beta-blockers, epinephrine, digoxin, and diuretics. Patients should inform their physician of all other medications they are taking prior to using this medication.Disease Interactions
Combair Respiratory may worsen congestive heart failure, hyperthyroidism, diabetes, angle-closure glaucoma, and benign prostate hypertrophy. Patients should inform their physician of such conditions prior to using this medication.Drug Interactions
Combair Respiratory may interact with a variety of medications including antacids, diuretics, digitalis glycosides, beta-blockers, anticholinergics, and adrenergic agonists. Patients should inform their physician of any other medications they are taking prior to using this medication.Food Interactions
Food has no known effect on the effectiveness of Combair Respiratory.Pregnancy Use
The use of Combair Respiratory has not been studied in pregnant women. Patients should inform their physician if they are pregnant prior to using this medication.Lactation Use
It is not known if Combair Respiratory is excreted in breast milk. Patients should consult their physician prior to taking this medication if they are breastfeeding.Acute Overdose
An acute overdose of Combair Respiratory could lead to serious side effects such as hypotension, tachycardia, and arrhythmia. It is important to seek medical attention immediately if any signs of an overdose are experienced.Contraindications
Combair Respiratory should not be used in patients with hypersensitivity to the drug or any of its components. It should also not be used in patients with severe asthma, tachyarrhythmia, or tachycardia.Direction for Use
Combair Respiratory should be used as directed by the physician or according to the directions provided on the package label. Patients should use the correct technique while using an inhaler device.Storage Condition
Combair Respiratory should be stored at room temperature, away from light and moisture. It should be kept out of the reach of children.Volume of Distribution
The volume of distribution of Combair Respiratory is not known.Half Life
The half-life of Combair Respiratory is not known.Clearance
The clearance of Combair Respiratory is not known.Here you find in details version of Combair Respiratory