Codapane Forte 500/30mg
Codapane Forte 500/30mg Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Codapane Forte 500/30mg is a brand name. Its generic name is paracetamol + codeine phosphate hemihydrate.
Paracetamol and Codeine Phosphate Hemihydrate
Introduction: Paracetamol and Codeine Phosphate Hemihydrate is a combination of two medicines, paracetamol and codeine phosphate hemihydrate. Paracetamol is a pain relieving medicine, while codeine phosphate hemihydrate is an opioid medicine, which acts on the brain to produce a calming effect and relief from pain. Both these medicines work together to provide relief from mild to moderate pain. It is used to treat pain ranging from mild to moderate pain and fever.
Uses:
Paracetamol and codeine phosphate hemihydrate is used to treat mild to moderate pain and fever. It can be used to treat headaches, toothaches, sore throats, colds, flu and other mild to moderate pains.
Mechanism of Action:
Paracetamol acts by blocking the production of chemical messengers in the brain that are responsible for pain and fever. Codeine phosphate hemihydrate is an opioid agonist that binds to certain opioid receptors in the brain and spinal cord, which causes the brain to release chemicals that block the transmission of pain signals. This results in a calming effect and relief from pain.
How Long Does it Take to Work?
The effects of paracetamol and codeine phosphate hemihydrate begin to be felt within 30 minutes after administration and peak after about 2 to 4 hours.
Absorption:
Paracetamol is rapidly and completely absorbed from the gut, while codeine phosphate hemihydrate is also rapidly absorbed from the gut, but may be incompletely bioavailable.
Route of Elimination:
Both paracetamol and codeine phosphate hemihydrate are mostly eliminated via the kidneys.
Dosage:
The recommended adult oral dose is 1 to 2 tablets taken every 4 to 6 hours as required, to a maximum of 8 tablets in 24 hours. The recommended adult dose for other preparations is up to 2 tablets every 4 hours if necessary, to a maximum of 8 tablets in 24 hours. Children’s doses should be calculated according to age and bodyweight.
Administration:
Paracetamol and codeine phosphate hemihydrate can be administered orally, with or without food. However, it is important to read the manufacturer’s instructions before taking paracetamol and codeine phosphate hemihydrate.
Side Effects:
Side effects include drowsiness, lightheadedness, nausea, vomiting, constipation, and confusion. Rarely, allergic reactions such as skin rashes and hives may occur.
Toxicity:
Paracetamol and codeine phosphate hemihydrate can be toxic in large doses. The toxicity of paracetamol and codeine phosphate hemihydrate can be increased with the use of other medications, alcohol, and/or certain medical conditions. Overdose can result in serious complications such as liver failure.
Precautions:
Paracetamol and codeine phosphate hemihydrate should be used with caution in patients with liver or kidney disease, asthma or bronchospasm, and in pregnancy or breastfeeding. It is not suitable for use in children under the age of 12 years.
Interactions:
Paracetamol and codeine phosphate hemihydrate may interact with other medications, including anticoagulants, antihistamines and medications for depression, anxiety, and insomnia. Taking paracetamol and codeine phosphate hemihydrate with alcohol or sedatives can increase the risk of serious side effects, such as breathing problems. Therefore, the combination should be avoided.
Disease Interaction:
Paracetamol and codeine phosphate hemihydrate should be used with caution in patients with liver or kidney disease, asthma or bronchospasm, and in pregnancy or breastfeeding.
Drug Interactions:
Paracetamol and codeine phosphate hemihydrate may interact with other medications, including anticoagulants, antihistamines and medications for depression, anxiety, and insomnia. Taking paracetamol and codeine phosphate hemihydrate with alcohol or sedatives can increase the risk of serious side effects, such as breathing problems. Therefore, the combination should be avoided.
Food Interactions:
Paracetamol and codeine phosphate hemihydrate can be taken with or without food. However, it is important to read the manufacturer’s instructions before taking paracetamol and codeine phosphate hemihydrate.
Pregnancy Use:
Paracetamol and codeine phosphate hemihydrate should be avoided during pregnancy unless absolutely necessary. If the medicine is required during pregnancy, it should be used at the lowest effective dose for the shortest possible period of time.
Lactation Use:
Paracetamol and codeine phosphate hemihydrate are not recommended for use during breastfeeding. If the medicine is required during breastfeeding, the benefits and risks should be carefully considered.
Acute Overdose:
Overdose of paracetamol and codeine phosphate hemihydrate can lead to serious complications, including liver failure, and should be treated as a medical emergency. Treatment of a paracetamol overdose should be started as soon as possible.
Contraindication:
Paracetamol and codeine phosphate hemihydrate is contraindicated in patients with a known hypersensitivity to any of the ingredients in the preparation, or in patients with severe hepatic impairment. It should also be avoided in patients with head injuries or with increased intracranial pressure.
Use Directions:
Paracetamol and codeine phosphate hemihydrate should be taken as directed by the doctor or pharmacist. The dose and frequency should be adjusted according to the patient's age, bodyweight, and severity of symptoms. It should not be used for longer than necessary and should not be used by children under the age of 12 years.
Storage Condition:
Paracetamol and codeine phosphate hemihydrate should be stored in a cool, dry place, away from direct sunlight and moisture. It should be kept away from children.
Volume of Distribution:
The volume of distribution of paracetamol and codeine phosphate hemihydrate is approximately 10-20 L/kg for paracetamol and 0.6-1.2 L/kg for codeine.
Half-Life:
Paracetamol and codeine phosphate hemihydrate has a plasma half-life of 2-3 hours for paracetamol and 2-4 hours for codeine.
Clearance:
The clearance of paracetamol and codeine phosphate hemihydrate is approximately 15-30 ml/min/kg for paracetamol and 0.25-0.50 ml/min/kg for codeine.
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