Cocalate

Cocalate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cocalate is a brand name. Its generic name is Calcium Dobesilate.

Cocalate

Cocalate is a medication used to improve blood circulation and reduce swelling of the extremities, as well as to treat acute or chronic venous ulcers and venous stasis. It is available in a variety of forms, such as tablets and topical gels, and is used primarily for local relief.

Uses

Cocalate is commonly used to improve blood circulation and reduce swelling of the extremities, as well as to treat acute or chronic venous ulcers and venous stasis. It is also used to treat eye disorders such as diabetic retinopathy and macular edema.

Mechanism of Action

The exact mechanism of action of Cocalate is not fully understood, however, it is believed to work by increasing the activity of antioxidant enzymes, decreasing vascular permeability, and decreasing vascular reactivity. Additionally, it is thought to act as an anti-inflammatory.

How Long Does It Take To Work?

Cocalate typically takes several weeks to months to take full effect. It is important to note that it is not an immediate relief medication.

Absorption

Cocalate is poorly absorbed after oral administration. The bioavailability of oral Cocalate is approximately 15%.

Route of Elimination

Cocalate is eliminated mainly in the urine within 24 hours of administration.

Dosage

Cocalate is available in tablets containing 250 mg, 500 mg, or 1000 mg; topical gels containing 2.5 mg/g; and eyedrops containing 0.5 mg/mL. The recommended dosage for dilated penile veins is 25–50 mg, two to three times daily. The usual starting dosage of Cocalate for venous ulcers is 1000 mg, three times daily. The dosage for venous stasis is 1000 mg, two times daily.

Administration

Cocalate can be administered orally, topically, or as an eyedrop. For oral administration, take with food or milk. For topical administration, apply to the affected area as directed by your doctor. For eyedrop administration, instill one drop in the affected eye twice daily.

Side Effects

Some common side effects associated with Cocalate include nausea, vomiting, constipation, headache, dizziness, and facial flushing. Contact your doctor if any of these side effects become severe or persist.

Toxicity

Cocalate is considered to be safe when used as directed. Overdose symptoms may include nausea, vomiting, dizziness, and tachycardia. If any of these symptoms occur, contact emergency medical services.

Precautions

Before taking Cocalate, tell your doctor if you are pregnant, breastfeeding, or have a history of liver disease, renal failure, or kidney disease. Cocalate may also make you more sensitive to sunlight, so use sun protection and limit your time in direct sunlight.

Interactions

Cocalate may interact with other medications you are taking, so be sure to tell your doctor about all the drugs and supplements you are taking. Cocalate may also increase the levels of bilirubin in your blood, so monitor your liver function while taking this medication.

Disease Interactions

Cocalate may cause a decrease in the effectiveness of some diseases, such as high blood pressure and diabetes. Be sure to tell your doctor about any and all health conditions to ensure that Cocalate is safe for you to take.

Drug Interactions

Cocalate may interact with certain drugs, including anticoagulants (blood thinners), diuretics, and some antibiotics. Check with your doctor before taking any other drugs while taking Cocalate.

Food Interactions

It is not known if Cocalate interacts with food. Be sure to take Cocalate with food or milk, as this may help to reduce side effects.

Pregnancy Use

Cocalate is likely not safe for use during pregnancy as it may be toxic to a developing fetus. Women should not take Cocalate during pregnancy unless instructed to do so by their healthcare provider.

Lactation Use

Cocalate is not recommended for use in breastfeeding women. It is not known if Cocalate passes into breast milk and could potentially harm an infant.

Acute Overdose

If an acute overdose of Cocalate is suspected, consult with a doctor or call emergency medical services immediately. Symptoms of an acute overdose may include nausea, vomiting, dizziness, and tachycardia.

Contraindication

Cocalate is contraindicated in individuals with a known hypersensitivity to the medication. It is also contraindicated in patients with severe congestive heart failure, liver disease, or kidney disease.

Use Direction

Follow all instructions given by your doctor when taking Cocalate. Take Cocalate orally, topically, or as an eyedrop, as per the prescribed dosage and instructions. Ensure you read all package instructions to ensure the correct dosage and method of administration.

Storage Conditions

Cocalate should be stored in a cool, dry place, away from direct sunlight and heat. Keep out of reach of children and away from pets.

Volume of Distribution

The volume of distribution of Cocalate is not known.

Half Life

The half life of Cocalate is approximately 5 hours.

Clearance

The renal clearance of Cocalate is not known.

Here you find in details version of Cocalate

Some Frequently Asked Questions About Cocalate

What is Cocalate?

Calcium dobesilate is a medication used to reduce swelling in the blood vessels, improve microcirculation, and relieve symptoms associated with chronic venous insufficiency. It works by preventing the leakage of albumin into the blood stream.

How does Cocalate work?

Calcium dobesilate works by inhibiting a key enzyme needed for the leakage of albumin from the blood vessel walls. In doing so, it improves microcirculation and reduces swelling in the affected area. It also increases the elasticity of the blood vessels, which can help to reduce symptoms of chronic venous insufficiency.

What are the potential side effects of Cocalate?

The most common potential side effects of calcium dobesilate include headache, dizziness, diarrhea, constipation, and stomach upset. If any of these symptoms develop, contact your doctor immediately. Other potential side effects may include nausea, rash, itching, and low or high blood pressure.

Who should not take Cocalate?

Calcium dobesilate should not be taken by pregnant or nursing mothers, patients who have low amounts of calcium in their blood (hypocalcemia), or people with an allergy or sensitivity to calcium dobesilate.

Does Cocalate have any interactions with other medications?

Calcium dobesilate may interact with certain medications, such as those used to treat heart conditions, high blood pressure, and diabetes. Be sure to tell your doctor about all medications and supplements you are taking before starting calcium dobesilate.

How long should I take Cocalate?

The length of treatment with calcium dobesilate will vary depending on each individual’s medical history and the severity of their symptoms. Generally, it is recommended to take calcium dobesilate for as long as prescribed by your doctor.

When should Cocalate be taken?

Calcium dobesilate should be taken as prescribed by your doctor. Generally, it is recommended to take calcium dobesilate twice a day with meals.

What is the dosage of Cocalate?

The dosage of calcium dobesilate will vary depending on each patient’s medical history and the severity of their symptoms. It is important to follow your doctor's instructions for the safest and most effective use of the medication.

What are the benefits of taking Cocalate?

The benefits of taking calcium dobesilate include improved microcirculation, reduction of swelling in the blood vessels, increased elasticity of the blood vessels, and relief of symptoms associated with chronic venous insufficiency.

Is Cocalate safe to take?

Yes, calcium dobesilate is generally considered safe to take when taken as prescribed by your doctor. If any side effects develop, stop taking the medication and contact your doctor immediately.

Is Cocalate available over-the-counter?

No, calcium dobesilate is a prescription medication and is not available over-the-counter.

Can Cocalate be used to treat other conditions?

Calcium dobesilate is FDA approved to treat chronic venous insufficiency and has not been approved for use in other conditions. Talk to your doctor about other treatments that may be available for your condition.

Does Cocalate have any effects on blood pressure?

Calcium dobesilate has been known to cause low or high blood pressure. If you experience any changes in your blood pressure while taking calcium dobesilate, contact your doctor immediately.

Can I take Cocalate with other medications?

It is generally safe to take calcium dobesilate with other medications, but it is important to tell your doctor about all medications and supplements you are taking before starting treatment. This will help your doctor determine the best course of treatment for you.

Does Cocalate have any effect on cholesterol levels?

Calcium dobesilate has not been documented to affect cholesterol levels, but it is important to speak to your doctor about any medications or supplements you are taking as they may interact with calcium dobesilate.

Does Cocalate need to be refrigerated?

No, calcium dobesilate does not need to be refrigerated. However, it is important to store the medication out of reach of children and in a cool, dry place.

How long do the effects of Cocalate last?

The effects of calcium dobesilate may begin to be felt shortly after taking it, but the overall effects may take up to several weeks to reach full effectiveness.

Will taking Cocalate cause weight gain?

There is no evidence that calcium dobesilate will cause weight gain. However, diet and exercise are important for overall health and should not be neglected while taking any medication.

Is Cocalate safe to take for extended periods of time?

Yes, calcium dobesilate can be taken for extended periods of time as long as your doctor approves. If any side effects develop, contact your doctor immediately.

Can I take Cocalate if I am pregnant or nursing?

No, calcium dobesilate should not be taken by pregnant or nursing mothers. Speak to your doctor about other treatments that may be available for your condition.

What are the symptoms of chronic venous insufficiency?

Common symptoms of chronic venous insufficiency include swelling of the legs and feet, aching, fatigue, and discoloration of the skin. If you experience any of these symptoms, contact your doctor for diagnosis and treatment.

What is the cost of Cocalate?

The cost of calcium dobesilate will vary based on each patient’s health insurance plan. Your doctor or pharmacist can provide more information about the cost of the medication.

Is Cocalate an anti-inflammatory?

No, calcium dobesilate is not an anti-inflammatory. It works by inhibiting the leakage of albumin from the blood vessels, improving microcirculation, and reducing swelling in the affected area.

Does Cocalate need to be taken with food?

Yes, it is generally recommended to take calcium dobesilate with food. This helps to improve the absorption of the medication.

How does Cocalate improve microcirculation?

Calcium dobesilate works by inhibiting a key enzyme needed for the leakage of albumin from the blood vessel walls. In doing so, it reduces swelling in the affected area and increases the elasticity of the blood vessels, which can help to improve microcirculation.

Do I need to take Cocalate every day?

Yes, it is important to take calcium dobesilate as prescribed by your doctor. Generally, it is recommended to take calcium dobesilate twice a day with meals in order to gain the maximum benefits.

Can Cocalate reduce swelling in my legs?

Yes, calcium dobesilate can be used to reduce swelling in the legs, as it prevents the leakage of albumin from the blood vessel walls and increases the elasticity of the blood vessels. However, it is important to note that other treatments may need to be used to reduce your symptoms.

Can I take Cocalate with other dietary supplements?

It is generally safe to take calcium dobesilate with other dietary supplements, but it is important to tell your doctor about all medications and supplements you are taking before starting treatment. This will help your doctor determine the best course of treatment for you.

Does Cocalate cause constipation?

Calcium dobesilate can cause constipation as a potential side effect. If you experience constipation while taking calcium dobesilate, contact your doctor immediately.

Does Cocalate cause nausea?

Nausea is one of the potential side effects of calcium dobesilate. If you experience nausea while taking calcium dobesilate, contact your doctor immediately.

Does Cocalate cause dizziness?

Dizziness is one of the potential side effects of calcium dobesilate. If you experience dizziness while taking calcium dobesilate, contact your doctor immediately.

Can Cocalate be used to treat leg cramps?

Calcium dobesilate has not been approved to treat leg cramps. Talk to your doctor about other treatments that may be available for your condition.

Can I order Cocalate online?

No, it is not recommended to order prescription medications online as it is important to receive them from a nationally-certified pharmacy. Talk to your doctor about getting a prescription for calcium dobesilate.

Is Cocalate available in generic form?

No, calcium dobesilate is not available in generic form. There are, however, generic versions of other medications used to treat chronic venous insufficiency.

What other medications are used to treat chronic venous insufficiency?

Other medications used to treat chronic venous insufficiency include diuretics, blood thinners, and compression stockings. Speak to your doctor about which medications are best for you.

Can I drink alcohol while taking Cocalate?

It is not recommended to drink alcohol while taking calcium dobesilate as it can interact with the medication and cause complications. If you are concerned, speak to your doctor before drinking alcohol.

Should I take Cocalate with food or on an empty stomach?

It is generally recommended to take calcium dobesilate with food. This helps to improve the absorption of the medication.

Does Cocalate cause headaches?

Headaches are one of the potential side effects of calcium dobesilate. If you experience a headache while taking calcium dobesilate, contact your doctor immediately.

What are the long-term effects of taking Cocalate?

The long-term effects of taking calcium dobesilate are not known, as it has not been studied over an extended period of time. Talk to your doctor about any concerns you may have.

Can Cocalate reduce fatigue?

Yes, calcium dobesilate may reduce fatigue by improving microcirculation and reducing swelling in the affected area. If your fatigue does not improve after taking calcium dobesilate, speak to your doctor.

Can Cocalate be used to treat spider veins?

No, calcium dobesilate is not used to treat spider veins. Speak to your doctor about other treatments that may be available for your condition.