Coagulation factor ix recombinant
Coagulation factor ix recombinant Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Coagulation factor ix recombinant is a brand name. Its generic name is Coagulation factor ix.
Coagulation Factor IX Introduction
Coagulation Factor IX (also known as Christmas Factor or Antihemophilic Factor B) is a clotting protein made by the liver. It is used to treat hemophilia B, a rare bleeding disorder in which blood does not clot properly. Treatment for hemophilia B typically consists of replacing the missing Factor IX protein with so-called factor concentrates made from donated blood. Factor IX concentrate is used to quickly stop bleeding episodes. It may also be preventive therapy if someone is at a higher risk of bleeding.
Uses For
Coagulation Factor IX is used to treat and prevent bleeding episodes in people with hemophilia B. It is also used to help control bleeding during surgery and invasive procedures in people with hemophilia.
Mechanism of Action
Coagulation Factor IX helps the body form blood clots and stop bleeding by activating the clotting process. It does this by binding to another clotting factor, Factor VIII, as part of the coagulation cascade. Factor IX binds to Factor VIII, which in turn activates Factor X, another clotting factor, which then activates prothrombin to form the enzyme thrombin. Thrombin then helps convert fibrinogen to fibrin, which helps form a blood clot.
How Long Does It Take to Work?
The time it takes for Factor IX to start working depends on the method of delivery. When Factor IX is administered intravenously, it typically begins to work in 15–30 minutes. Factor IX may also be delivered via injection directly into a muscle (intramuscular). When Factor IX is administered intramuscularly, it may take longer for it to start working, but it may last longer in the body.
Absorption
Factor IX is rapidly and fully absorbed when given by intravenous or intramuscular injection. Blood levels reach a peak in approximately 30 minutes and the half-life is approximately 24 hours.
Route of Elimination
Factor IX is eliminated from the body in a combination of processes. It is cleared from the body by the kidneys and intestine, and is also metabolized by the liver.
Dosage and Administration
Factor IX is provided in a solution that must be diluted before use. The recommended dosage for treating or preventing bleeding episodes is based on the weight of the patient. The recommended dosage typically ranges from 100-150 units/kg. The dose may be given in one or two divided doses. If given in a single dose, the dose can be administered intravenously or intramuscularly, depending on the patient's needs. If given in two divided doses, the doses must be given intravenously.
Side Effects
Common side effects of Factor IX include: headaches, redness and swelling at the site of injection, nausea, and rash. Factors IX can also cause an allergic reaction. In rare cases, it can also cause a potentially severe allergic reaction known as anaphylaxis. In this case, it is important to seek medical treatment immediately.
Toxicity
Because Factor IX is made from human blood-derived components, it has the potential to transmit infectious diseases, such as hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Precaution should be taken to ensure that proper safety testing and screening of the donor source is done.
Precautions
It is important to tell your healthcare provider before starting or if you are already taking any medications, including anticoagulants (such as warfarin, heparin), anti-platelet drugs (such as aspirin), or other clotting products. The dose of these medications may need to be adjusted.
Interactions
Factor IX may interact with other drugs. It is important to tell your healthcare provider about all other medications that you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Your healthcare provider will determine if any drug interactions may occur.
Disease Interactions
Factor IX may interact with certain diseases, such as hepatitis B or C infection, cancer, or HIV infection. It is important to tell your healthcare provider about any diseases or other medical conditions before using Factor IX.
Drug Interactions
Factor IX may interact with certain drugs. Your healthcare provider will determine if any drug interactions may occur.
Food Interactions
No food interactions have been reported with Factor IX.
Pregnancy Use
Category C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. Factor IX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation Use
Factor IX is excreted in human milk. Caution should be exercised when Factor IX is administered to a lactating woman.
Acute Overdose
An overdose of Factor IX can be serious and potentially life-threatening. Symptoms of an overdose may include severe headache, chest pain, bleeding, lightheadedness, shortness of breath, and fainting. If an overdose is suspected, seek immediate medical attention.
Contraindications
Factor IX is contraindicated in people with a known hypersensitivity to Factor IX. In addition, Factor IX is not to be used in people with certain coagulation disorders, such as thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, or deficiencies of antithrombin III.
Use Direction
Factor IX is to be administered intravenously or intramuscularly as directed by your healthcare provider. Factor IX is provided in a solution that must be diluted before use. The dose and administration method may vary depending on the patient’s needs.
Storage Conditions
Factor IX should be stored at 2-8°C (36-46°F). It should never be frozen. If it is exposed to high temperatures, it should be discarded.
Volume of Distribution
The volume of distribution of Factor IX is 150 L.
Half Life
The half life of Factor IX is approximately 24 hours.
Clearance
The clearance of Factor IX is approximately 6.3 hours.
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