Cisplatin

Cisplatin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cisplatin is a brand name. Its generic name is Cisplatin.

Cisplatin

Cisplatin is a chemotherapy drug used to treat various forms of cancer, including ovarian, bladder, lung, testicular, head and neck, and cervical. It is a platinum-based drug that works by stopping the cancer cells from dividing and reproducing.

Uses for Cisplatin

Cisplatin is used in combination with other drugs or radiation to try to kill cancer cells. It is used to treat certain types of ovarian, bladder, testicular, head and neck, and cervical cancers in adults and children. Cisplatin may also be used to treat some kinds of tumors in the brain, lung, esophagus, and neck.

Mechanism of Action

Cisplatin works by damaging the DNA of cancer cells, making them unable to divide and grow. The damaged DNA forces the cancer cells to die, which helps stop the growth of the tumor. It is also used to damage the cells of the tumor so surgery can be performed safely.

How Long Does it Take to Work?

The effects of Cisplatin can be seen within a few days after the start of treatment. The amount of time that it takes for the cancer cells to be destroyed can vary depending on the type of cancer being treated.

Absorption

Cisplatin is absorbed in the stomach and small intestine. It is then distributed throughout the body in the bloodstream. The absorption rate of Cisplatin is about 80%.

Route of Elimination

Cisplatin is eliminated mainly in the urine. It is metabolized in the liver and after about 7 hours, it is mostly eliminated in the urine.

Dosage

Cisplatin is typically dosed at 30 to 90 mg/m2 of body surface every 3–4 weeks. The dose may be adjusted depending on the patient's body size, type of cancer, and how the patient tolerates the drug. A healthcare provider should be consulted to determine the appropriate dose for a particular patient.

Administration

Cisplatin is generally given intravenously (injected into a vein) over a period of several hours. It may also be given intramuscularly if a patient is unable to receive the intravenous treatment. It is important to follow the instructions of a healthcare provider when administering Cisplatin.

Side Effects

Cisplatin can cause various side effects, including loss of appetite, nausea, vomiting, fever, diarrhea, fatigue, increased risk of infection, hair loss, and numbness or tingling in the hands and feet. These side effects may be worse if the drug is taken with other chemotherapy drugs. It is important to speak with a healthcare provider about the potential risks and side effects of taking Cisplatin.

Toxicity

Cisplatin can be toxic to the body if taken at too high a dose or in combination with other drugs. It is important to follow the instructions of a healthcare provider carefully when taking Cisplatin. Signs of toxicity include nausea, vomiting, and muscle twitching. If any of these symptoms occur, it is important to seek medical attention immediately.

Precautions

Before taking Cisplatin, it is important to consult with a healthcare provider about any medical history and allergies. It is also important to tell the healthcare provider about any other medications that are being taken, including non-prescription medicines, herbal supplements, and vitamins.

Interactions

Cisplatin should not be taken with other chemotherapy drugs or with certain antibiotics. It can also interact with blood thinners, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs). It is important to speak with a healthcare provider about any potential drug interactions before taking Cisplatin.

Disease Interaction

Cisplatin can interact with certain medical conditions. It is important to discuss any medical conditions with a healthcare provider before taking Cisplatin. These conditions include kidney disease, hearing loss, anemia, and certain heart conditions.

Drug Interaction

Cisplatin can interact with certain drugs, including certain antibiotics, blood thinners, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs). It is important to discuss any potential drug interactions with a healthcare provider before taking Cisplatin.

Food Interactions

Cisplatin should not be taken with dairy products, iron-rich foods (e.g. beef, shellfish, and broccoli), or foods high in nitrates (e.g. processed meats). It should also be taken on an empty stomach to ensure maximum absorption.

Pregnancy Use

Cisplatin may be used to treat certain types of cancer during pregnancy. However, there is a risk of birth defects or other complications when taking this medication during pregnancy. It is important to discuss the risks and benefits with a healthcare provider before taking Cisplatin during pregnancy.

Lactation Use

Cisplatin should not be taken by lactating women, as it has been shown to pass into breast milk. It is important to discuss the risks and benefits with a healthcare provider before taking Cisplatin while breastfeeding.

Acute Overdose

If an overdose of Cisplatin is suspected, a healthcare provider should be consulted immediately. Symptoms of an overdose can include nausea, vomiting, stomach pain, and abnormal bleeding. It is important to follow the instructions of a healthcare provider when taking Cisplatin.

Contraindication

Cisplatin is contraindicated in patients with kidney or liver disease, hearing loss, anemia, bleeding disorders, certain heart conditions, and certain infections. It is important to speaks with a healthcare provider before taking Cisplatin.

Use Direction

Cisplatin should only be used as directed by a healthcare provider. It is important to follow the dosage instructions carefully when taking Cisplatin. The drug should be taken on an empty stomach, and it should not be taken with dairy products, iron-rich foods, or foods high in nitrates.

Storage Condition

Cisplatin should be stored at room temperature, away from excess heat and moisture. It should not be frozen or refrigerated. It is important to keep the medication out of the reach of children and pets.

Volume of Distribution

The volume of distribution of Cisplatin is 5.5 L/kg. This means that the drug is distributed throughout the body in the blood and tissue.

Half Life

The half life of Cisplatin is approximately 8-10 hours. This is the amount of time it takes for the drug to be reduced by half in the body.

Clearance

The clearance of Cisplatin is approximately 0.25 to 0.4 L/hr/kg. This is the rate at which the drug is eliminated from the body.

Here you find in details version of Cisplatin

Some Frequently Asked Questions About Cisplatin

What is Cisplatin?

Cisplatin is a chemotherapy drug used to treat a variety of cancers. It works by stopping the growth of cancer cells by binding to their DNA and stopping them from multiplying.

What type of cancer is Cisplatin used to treat?

Cisplatin is used to treat a variety of cancers, including bladder cancer, ovarian cancer, and testicular cancer.

How does Cisplatin work?

Cisplatin works by binding to DNA within cancer cells, which prevents them from multiplying and leads to their eventual death.

What are the side effects of Cisplatin?

Common side effects of Cisplatin include nausea, vomiting, diarrhea, constipation, hair loss, and fatigue.

How is Cisplatin administered?

Cisplatin is usually given intravenously as an injection or infusion into a vein.

How often is Cisplatin given?

The frequency of Cisplatin depends on the type and stage of cancer being treated. Your doctor will determine the best schedule for you.

What should I do if I experience side effects?

If you experience any side effects, it is important to let your doctor or healthcare team know right away. They can help you manage and reduce any possible side effects.

What are the possible drug interactions with Cisplatin?

You should tell your healthcare team about any medicines you are taking. Certain medicines can interact with Cisplatin and increase the risk of side effects.

What should I do if I miss a dose of Cisplatin?

If you miss a dose of Cisplatin, it is important to contact your doctor right away. Do not take a double dose to make up for a forgotten dose.

What are the long-term effects of Cisplatin?

Long-term effects from Cisplatin can include kidney damage, hearing loss, as well as nerve damage or an increased risk of infection.

Is there a risk of Cisplatin resistance?

Yes, some cancers may become resistant to Cisplatin over time. This is why it is important to follow your doctor's directions and have regular tests to check for resistance.

Can Cisplatin cause infertility?

Yes, Cisplatin can cause infertility in both men and women. If you are considering having children, it is important to discuss this with your doctor before starting Cisplatin treatment.

Do I need a special diet while taking Cisplatin?

It is important to eat a healthy diet while taking Cisplatin. Your doctor may recommend a specific diet or suggest foods that may help to reduce side effects. Speak to your doctor or healthcare team about any specific dietary needs.

What should I do if I become pregnant while taking Cisplatin?

If you become pregnant while taking Cisplatin, it is important to contact your doctor. Cisplatin is not recommended during pregnancy and it can be dangerous for the baby if taken during pregnancy.

What if I experience a severe allergic reaction to Cisplatin?

If you experience a severe allergic reaction to Cisplatin, it is important to seek immediate medical attention.

What other medications should I avoid while taking Cisplatin?

You should avoid taking any other medications without first consulting with your doctor. Certain medications can interact with Cisplatin and increase your risk of side effects.

Are there any specific foods or beverages I should avoid while taking Cisplatin?

It is important to follow your doctor's recommendations when it comes to diet and Cisplatin. Eating a healthy balanced diet and avoiding alcohol and cigarettes can help reduce the risk of side effects.

Can I drink alcohol while taking Cisplatin?

No, it is not advised to drink alcohol while taking Cisplatin. Doing so can increase your risk of serious side effects.

What should I do if I am feeling anxious or depressed while taking Cisplatin?

It is normal to feel anxious or depressed while taking Cisplatin. Speak to your doctor or healthcare team about your feelings and they can discuss ways to manage them.

Can I take antibiotics while taking Cisplatin?

Yes, you can take antibiotics while taking Cisplatin, but it is important to let your doctor or healthcare team know so they can ensure there are no drug interactions.

Can I take over-the-counter medications while taking Cisplatin?

It is important to check with your doctor before taking any over-the-counter medications while taking Cisplatin, as some may interact with the drug and increase your risk of side effects.

Can I drive while taking Cisplatin?

It is not advised to drive while taking Cisplatin due to the risk of side effects like fatigue, nausea, and dizziness.

Can Cisplatin treat advanced cancer?

Cisplatin can be used to treat advanced cancer, but its effectiveness can vary depending on the type and stage of cancer being treated.

Can Cisplatin be used to treat cancers that have spread to other parts of the body?

Yes, Cisplatin can be used to treat cancers that have spread to other parts of the body. However, its effectiveness can vary depending on the type and stage of cancer being treated.

Can Cisplatin be used in combination with other chemotherapy drugs?

Yes, Cisplatin can be used in combination with other chemotherapy drugs. Your healthcare team will determine the best combination of drugs for you.

How long does it take for Cisplatin to take effect?

The length of time it takes for Cisplatin to take effect varies depending on the type and stage of cancer being treated. It typically takes a few weeks to see results.

Can Cisplatin be used to treat children?

Cisplatin can be used to treat certain types of childhood cancer. However, due to its potential for side effects, it is typically only used as a last resort after other treatments have been tried.

Do I need to have regular tests while taking Cisplatin?

Yes, it is important to have regular tests while taking Cisplatin. Your doctor may order regular blood tests, urine tests, and x-rays to check for side effects and monitor the effectiveness of the treatment.

Is Cisplatin covered by insurance?

The cost of Cisplatin can vary depending on your insurance provider. It is important to contact your insurance provider to determine what, if any, costs are covered by your plan.

Can I continue working while taking Cisplatin?

Depending on the type of job you have, it may be possible to continue working while taking Cisplatin. It is important to talk to your doctor or healthcare team about your daily activities before starting Cisplatin treatment.

How long does Cisplatin stay in the body?

The amount of time Cisplatin stays in the body varies depending on the individual. Cisplatin can stay in the body for several weeks or months after treatment has been completed.

Can Cisplatin cause birth defects?

It is possible for Cisplatin to cause birth defects if taken during pregnancy. It is important to speak to your doctor before starting Cisplatin treatment if there is a possibility of becoming pregnant in the future.

What should I do if I think I have been exposed to Cisplatin?

If you think you have been exposed to Cisplatin, it is important to contact your doctor right away. Exposure to Cisplatin can be dangerous and it is important to seek medical attention as soon as possible.

Do I need to take a different form of contraception while taking Cisplatin?

Yes, it is important to talk to your doctor about contraception while taking Cisplatin. Certain forms of birth control can increase your risk of side effects.

Can I get a flu shot while taking Cisplatin?

Yes, it is typically safe to get a flu shot while taking Cisplatin. However, it is important to speak to your doctor about any additional vaccinations you may need while taking the drug.

Are there any long-term effects of Cisplatin?

Yes, there can be long-term effects from Cisplatin, such as hearing loss, nerve damage, or an increased risk of infection. It is important to speak to your healthcare team about any long-term effects you may experience.