Cetyltrimethylammonium Ion
Cetyltrimethylammonium Ion Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cetyltrimethylammonium Ion is a brand name. Its generic name is Cetrimonium.
Cetyltrimethylammonium Ion Introduction
Cetyltrimethylammonium Ion is an organic trimeric amine derived from a mixture of fatty acids that can be used as a surfactant in cosmetics and personal care products. It helps to reduce the surface tension of aqueous solutions, allowing them to spread easily and bind better to surfaces. It is a quaternary ammonium compound, which carries a positively charged nitrogen atom surrounded by four alkyl groups.
Uses For Cetyltrimethylammonium Ion
Cetyltrimethylammonium Ion is used in cosmetics and personal care products, such as soaps, shampoos, hair conditioners, body washes, and creams, to improve the spreadability of the product, to mask odors, and to increase the foaming ability. It is also used as an antiseptic to preserve and protect products from microbial contamination.
Mechanism Of Action
The mechanism of action of cetrimonium is believed to be due to its strong positive charge that can strongly interact with the negatively charged cell membrane of microorganisms. When the cetrimonium ions come into contact with the negatively charged cell membrane, they disrupt and destroy the membrane, leading to the death of the microorganism.
How Long Does It Take To Work?
Cetyltrimethylammonium Ion is an effective microbicide, and its antiseptic action is typically observed within minutes of application. The speed of the antiseptic action is largely dependent on the concentration of the cetrimonium, the concentration of the microorganism, and environmental conditions.
Absorption
Cetyltrimethylammonium Ion is slowly absorbed through the skin and has a low risk of adverse effects when applied topically. It is quickly metabolized by the liver and eliminated from the body through urine.
Route Of Elimination
Cetyltrimethylammonium Ion is primarily eliminated through the urine via kidney excretion. It is also partially eliminated through the feces.
Dosage
The recommended dose of cetrimonium is dependent on a patient’s age, underlying medical conditions, and body weight. The lowest effective dose should be used. Generally, 0.5 – 2 % cetrimonium is used in many cosmetic and personal care products.
Administration
Cetyltrimethylammonium Ion can be administered topically in the form of a soap, shampoo, cream, or lotion. It can also be administered transdermally in the form of a patch.
Side Effect
Side effects of cetrimonium are rare but may include skin irritation, redness, and itching. In some rare cases, cetrimonium may cause allergic reactions, such as hives, rash, or swelling of the face, lips, tongue, or throat.
Toxicity
Cetyltrimethylammonium Ion is generally considered to be minimally toxic, and no adverse effects have been reported as a result of oral, dermal, or inhalation exposure. It is not considered to be mutagenic or carcinogenic, and no reproductive or developmental effects have been reported.
Precaution
Cetyltrimethylammonium Ion should be used with caution in those with known hypersensitivity to it or any other ingredients in the product. It should also be avoided in those with skin conditions such as eczema or psoriasis.
Interactions
Cetyltrimethylammonium Ion can interact with certain drugs and may affect their activity. It is advised to consult with a healthcare professional before taking any medications while using a cetrimonium-containing product.
Disease Interactions
Cetyltrimethylammonium Ion may interact with certain diseases and may affect their course. Therefore, it is advised to consult with a healthcare professional before using any cetrimonium-containing product if one has kidney, liver, or heart disease.
Drug Interactions
Cetyltrimethylammonium Ion may interact with certain drugs and may affect their activity. It is advised to consult with a healthcare professional before taking any medications while using a cetrimonium-containing product.
Food Interactions
Cetyltrimethylammonium Ion does not interact with food and is not believed to interact with any foods.
Pregnancy Use
Cetyltrimethylammonium Ion is generally considered safe for use in pregnant women, however, it is advisable to consult with a healthcare professional before use.
Lactation Use
Cetyltrimethylammonium Ion is generally considered safe for use in lactating women, however, it is advisable to consult with a healthcare professional before use.
Acute Overdose
An acute overdose of cetrimonium is not expected to cause any systemic effects or toxicity. In case of accidental ingestion, consult with a healthcare professional for appropriate medical care.
Contraindications
Cetyltrimethylammonium Ion should not be used in those with an allergy or hypersensitivity to it or any of its ingredients. It should also be avoided in those with a history of kidney, liver, or heart disease.
Use Direction
Cetyltrimethylammonium Ion should be used according to the directions on the package or as prescribed by a healthcare professional. It can be used in the form of a soap, shampoo, cream, or lotion, and applied topically to the desired area. If necessary, it can be used in the form of a patch.
Storage Conditions
Cetyltrimethylammonium Ion should be stored in a cool, dry place, away from direct sunlight and heat. It should be stored at room temperature (below 77°F or 25°C).
Volume Of Distribution
Cetyltrimethylammonium Ion is well distributed in the body, with an apparent volume of distribution of between 16–36 L/kg in humans.
Half Life
The average elimination half-life of cetrimonium in humans is estimated to be about 3.3 hours.
Clearance
The clearance rate of cetrimonium in humans is estimated to be about 13.9 ml/min/kg.
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