Cervidil

Cervidil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cervidil is a brand name. Its generic name is Dinoprostone.

Cervidil

Cervidil is a naturally occurring hormone-like substance that is used to help induce labor or complete an abortion. It is also known as PGE2 or prostaglandin E2.

Uses

Cervidil is used to induce labor in pregnant women who can safely experience childbirth, and to ripen the cervix of pregnant women who require induction of labor. It is also used to complete a medical abortion.

Mechanism of Action

Cervidil stimulates the uterus to contract and is also thought to act in various other ways to prepare the uterus for labor.

How Long Does It Take To Work?

Cervidil usually takes between 30 minutes and 6 hours to begin working. Once dinoprostone is administered, the patient should be monitored closely for changes in contractions.

Absorption

Cervidil is rapidly absorbed when administered via vaginal suppository or gel.

Route of Elimination

Cervidil is rapidly metabolized and eliminated through the kidneys when administered vaginally, but can also be eliminated via other routes.

Dosage

When dinoprostone is used to induce labor, the recommended dosage is a single 0.5 mg to 2 mg suppository or 3mg to 5 mg gel, depending on the patient’s age and medical history. When used to complete a medical abortion, the dose is 0.5 mg.

Administration

Cervidil is administered intravaginally via a suppository or gel.

Side Effect

The most common side effects associated with the use of dinoprostone include nausea, vomiting, diarrhea, and increased contractions.

Toxicity

The safety of dinoprostone has not been evaluated in humans. It should only be used under medical supervision and appropriate dosing must be observed. Overdoses are possible with dinoprostone.

Precaution

It is important to use caution when administering dinoprostone. It is essential that the patient is monitored closely for signs of labor or other side effects. Those with allergies to any form of prostaglandin or with a history of medical complications should avoid the use of dinoprostone.

Interaction

Cervidil may interact with other medications, including anticoagulants, blood thinners, and anti-inflammatory drugs.

Disease Interaction

Cervidil can worsen the symptoms of asthma, heart failure, and diabetes, and should not be used in those with such preexisting conditions.

Drug Interaction

Cervidil can interact negatively with other medications, including anticoagulants, blood thinners, and anti-inflammatory drugs.

Food Interactions

Cervidil should not be taken with certain foods that can swell in the stomach or increase absorption rate. Examples include dairy products, high-fat meals, and alcoholic beverages.

Pregnancy Use

Cervidil is not recommended for use in pregnant women due to potential risk to the fetus.

Lactation Use

Cervidil is not recommended for use in lactating women due to potential risk to the infant.

Acute Overdose

Symptoms of acute overdose include nausea, vomiting, abdominal discomfort, and increased abdominal cramps. Patients experiencing serious side effects should seek immediate medical attention.

Contraindications

Cervidil is contraindicated in pregnant women, those with a history of abortion or miscarriage, and those with a history of any allergy to a prostaglandin.

Use Directions

When using dinoprostone, be sure to closely follow the directions provided by your doctor or pharmacist.

Storage Condition

Cervidil should be stored at room temperature and away from direct sunlight.

Volume of Distribution

Cervidil is rapidly absorbed when administered intravenously and has an estimated volume of distribution of 0.29 L/kg.

Half Life

The elimination half-life of dinoprostone is estimated to be 6 to 10 minutes when administered intravenously.

Clearance

The clearance of dinoprostone is estimated to be 0.13 L/kg/min when administered intravenously.

Here you find in details version of Cervidil

Some Frequently Asked Questions About Cervidil

What is Cervidil?

Cervidil is a synthetic form of prostaglandin E2, a naturally occurring hormone involved in beginning the process of labor in pregnant women.

When is Cervidil usually used?

Cervidil is usually used to induce or augment labor when a pregnant woman's obstetrician determines it is medically necessary.

What are the potential risks related with Cervidil?

The potential risks associated with Cervidil include maternal adverse events such as nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal adverse events such as fetal heart rate abnormalities.

What kind of delivery is Cervidil typically used for?

Cervidil is typically used for vaginal delivery, but can also be used for Cesarean section deliveries.

What is the usual dosage for Cervidil?

The usual dosage for Cervidil is 0.5 mg (measured in milligrams) every 6-8 hours.

How does Cervidil work?

Cervidil works by stimulating the smooth muscle tissue in the uterus, which encourages contractions that can help to open (dilate) the cervix.

How is Cervidil used?

Cervidil is usually administered as a vaginal gel or a tablet that is placed in the vagina. It can also be injected directly into the uterus.

What are the side effects associated with the use of Cervidil?

The side effects associated with the use of Cervidil include nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal heart rate abnormalities.

How long does it take for Cervidil to take effect?

It typically takes around 30 minutes for Cervidil to take effect.

What is the maximum dose of Cervidil that can be used?

The maximum safe dose of Cervidil is 10 mg.

Can Cervidil be used for a preterm labor?

Cervidil can be used for a preterm labor but the use of Cervidil in preterm labor is not currently recommended by the American College of Obstetricians and Gynecologists (ACOG).

Can Cervidil be used to induce labor?

Yes, Cervidil is often used to induce labor when a pregnant woman's obstetrician determines it is medically necessary.

How quickly can Cervidil be administered?

Cervidil can be administered as quickly as every 6-8 hours depending on the doctor's discretion.

Is Cervidil safe for pregnant women?

Yes, Cervidil is generally considered safe for pregnant women when used as prescribed.

How long does it typically take for Cervidil to be effective?

It typically takes around 30 minutes for Cervidil to be effective.

What are the effects of Cervidil on the fetus?

The effects of Cervidil on the fetus can include fetal heart rate abnormalities.

What are the common side effects of Cervidil?

The common side effects of Cervidil include nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal heart rate abnormalities.

What happens if Cervidil is not effective in inducing labor?

If Cervidil is not effective in inducing labor, doctors may recommend other methods of induction such as oxytocin infusion or the use of antibiotics.

How long after Cervidil is administered does labor usually begin?

Labor usually begins within 24 hours of Cervidil administration.

Does Cervidil cause any long-term side effects?

There have been no reported long-term side effects associated with the use of Cervidil.

Is Cervidil effective in all cases?

No, Cervidil may not be effective in some cases, such as when the cervix is not sufficiently dilated or when the placenta is positioned over the cervix.

Can Cervidil be used to induce labor at home?

No, Cervidil should not be used to induce labor at home, as it is a prescription drug and should only be administered in a medical setting.

Does Cervidil increase the risk of complications for mother and baby?

Cervidil increases the risk of certain maternal adverse events, such as nausea, vomiting, diarrhea, and uterine hyperstimulation, as well as fetal adverse events, such as fetal heart rate abnormalities.

Can Cervidil be used for c-sections?

Yes, Cervidil can be used for both vaginal deliveries and Cesarean section (c-section) deliveries.

What are the signs of Cervidil working properly?

The signs of Cervidil working properly include increased uterine activity, increased cervical dilation, and increased descent of the fetus.

What happens if Cervidil is discontinued?

If Cervidil is discontinued, the labor process will stop and further medical intervention may be necessary.

What should be done if Cervidil does not produce effective labor contractions?

If Cervidil does not produce effective labor contractions, then doctors may recommend administration of oxytocin infusion or the use of antibiotics.

Can Cervidil be used for multiple gestations?

Yes, Cervidil can be used for multiple gestations.

Can Cervidil cause fetal distress?

Yes, the use of Cervidil can cause fetal distress, which is characterized by fetal heart rate abnormalities.

What should be done if there is excessive uterine activity after the use of Cervidil?

If there is excessive uterine activity after the use of Cervidil, the dose should be immediately reduced and medical attention should be sought.

Can Cervidil be used to initiate labor in an elective cesarean delivery?

Yes, Cervidil can be used to initiate labor prior to elective cesarean sections.

Can Cervidil be used to shorten labor?

Yes, Cervidil can be used to shorten labour.

What are the contraindications for the use of Cervidil?

The contraindications for the use of Cervidil include, but are not limited to placental previa, previous cesarean section or uterine surgery, an intrauterine pregnancy with an unknown location, fetal macrosomia, and umbilical cord presentation.

What is the recommended monitoring frequency during Cervidil administration?

It is recommended that the fetal heart rate be monitored continuously while administering Cervidil.

Can Cervidil be used for painful labor?

Yes, Cervidil can be used to induce labor in order to reduce the painful contractions associated with labor.

How can Cervidil be administered?

Cervidil is typically administered as a vaginal gel or a tablet that is placed in the vagina. It can also be injected directly into the uterus.

What are the side effects of Cervidil on the mother?

The side effects of Cervidil on the mother include nausea, vomiting, diarrhea, and uterine hyperstimulation.

Does the use of Cervidil increase the risk of infection?

Yes, the use of Cervidil can increase the risk of infection if used for an induction/augmentation process, as Cervidil can contribute to prolonged labor.

Can Cervidil be used with oxytocin?

Yes, Cervidil can be used in combination with oxytocin when medically necessary.

What should be done if fetal distress is detected during the use of Cervidil?

If fetal distress is detected during the use of Cervidil, the dose should be reduced and medical attention should be sought.

What are the alternatives to the use of Cervidil?

Alternatives to the use of Cervidil include the use of oxytocin, antibiotics, and the insertion of a Foley catheter.