Certine

Certine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Certine is a brand name. Its generic name is Ranitidine.

Introduction

Certine is a histamine-2(H2)-blocker used to treat and prevent stomach and duodenal ulcers, and to treat other stomach and gastrointestinal conditions. It is an over-the-counter drug, available both as a prescription and non-prescription medication.

Uses

Certine is used to treat gastrointestinal disorders such as gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excessive stomach acid. It can also be used to prevent stress ulcers, to treat heartburn, and to reduce the occurrence of stomach or duodenal ulcers

Mechanism of Action

Certine works by reducing the amount of acid produced by the stomach, therefore reducing the symptoms of heartburn and other gastrointestinal conditions. It does this by blocking histamine-2, which reduces the amount of acid production in the stomach in response to food.

How Long Does it Take to Work?

Certine begins to reduce stomach acid production and improve symptoms within a few hours or days after the first dose. The maximum benefit is usually reached within 4 weeks.

Absorption

Certine is well absorbed in the stomach and intestine. It has an oral absorption rate of 65-80%.

Route of Elimination

Certine is eliminated by the kidneys through urine via glomerular filtration and tubular secretion. Its elimination half-life is 1-2 hours.

Dosage

Certine is available in tablets, capsules, and suspension forms. The dosage forms and strengths are as follows:

• Tablet: 75 mg, 150 mg, and 300 mg
• Capsules: 75 mg and 150 mg
• Suspension: 10 mg/mL

The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

For treatment of esophageal reflux, the usual dose is 150 to 300 mg twice daily. For maintenance of healing of esophageal lesions, the recommended dose is 150 mg once daily.

For treatment of conditions involving excessive stomach acid, the recommended dose is 150 to 300 mg twice daily.

Administration

Certine can be taken with or without food. It should be taken with a full glass of water to ensure that it is completely absorbed. It is important to consume the full amount of water that is recommended for each dose.

Side Effects

Common side effects of ranitidine include headache, diarrhea, constipation, nausea, rash, dizziness, and abdominal pain. Less common side effects may include muscle pain, joint pain, fever, mental confusion, and depression.

Toxicity

Certine has a low toxicity and is generally well tolerated. Large doses may cause hypotension and can be fatal in cases of overdose.

Precautions

Certine should be used with caution in people with kidney or liver disease, and those with a history of drug allergies.

Interactions

Certine may interact with other medications including antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines.

Disease Interactions

Certine should not be used in people with porphyria, a rare metabolic disorder. It should also be used with caution in people with severe kidney disease.

Drug Interactions

Certine can interact with certain medications such as antacids, drugs used to treat heartburn, anti-seizure medications, certain antibiotics, and theophyllines. Be sure to discuss all medications you are taking with your healthcare provider before taking ranitidine.

Food Interactions

Certine may interact with food. Consuming alcohol while taking ranitidine may increase the risk of side effects such as headache, dizziness, and drowsiness.

Pregnancy Use

Certine should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Be sure to discuss the use of ranitidine with your healthcare provider before using it during pregnancy.

Lactation Use

Certine is excreted in breast milk and may affect a nursing baby. Therefore, it should be used with caution in breastfeeding women.

Acute Overdose

If an overdose of Certine occurs, seek medical attention immediately. Symptoms of overdose may include low blood pressure, dizziness, and unusual sleepiness.

Contraindication

Certine is contraindicated in people who are allergic to the active ingredient in the drug.

Use Direction

Certine should be taken as directed by your healthcare provider. The usual adult dose for treatment of active duodenal ulcers is 150 mg to 300 mg twice daily. For maintenance of healing of duodenal ulcers, 150 mg once daily is recommended.

Storage Condition

Certine should be stored at room temperature, away from heat and moisture. Keep out of reach of children.

Volume of Distribution

The apparent volume of distribution for Certine is 5L/kg.

Half Life

The half-life of Certine is 1-2 hours.

Clearance

The clearance for Certine is 10 mL/min/kg.

Here you find in details version of Certine

Some Frequently Asked Questions About Certine

What is Certine?

Certine is an over-the-counter and prescription histamine-2 blocker or H2 blocker used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison Syndrome (ZES) and other conditions caused by too much acid in the stomach.

How does Certine work?

Certine works by inhibiting the production of acid in the stomach, thus reducing the symptoms of acid reflux. It can also protect the lining of the stomach from damage due to the excess stomach acid.

What is the brand name of Certine?

The brand name of Certine is Zantac.

What is the dosage of Certine?

The dosage of Certine depends on the medical condition and age of the patient; however, the usual dosage for adults in the treatment of acid reflux is 150 mg twice a day.

What are the side effects of Certine?

The most common side effects of Certine include headache, dizziness, nausea, and diarrhea. Other less common side effects include constipation, stomach pain, and rash.

Does Certine interact with other medications?

Yes, Certine can interact with other medications such as anticoagulants, sulfonylureas, and NSAIDs. Talk to your doctor or pharmacist before taking any other medication while taking Certine.

What is the difference between Certine and Famotidine?

Certine and Famotidine are both H2 blockers used for treating acid reflux and GERD. The main difference between them is that Certine is more effective for treating Zollinger-Ellison Syndrome. In terms of side effects, Certine may cause headaches and dizziness, while Famotidine may cause diarrhea.

Can I take Certine while pregnant/breastfeeding?

It is not recommended to take Certine while pregnant or breastfeeding as it may be harmful to the fetus or infant. Talk to your doctor before taking Certine during pregnancy or while breastfeeding.

How long does it take for Certine to work?

Certine usually begins to work within an hour of taking it and continues to work for up to 12 hours.

Can I take Tylenol (acetaminophen) and Certine together?

Yes, it is safe to take Tylenol (acetaminophen) and Certine together.

Is Certine a laxative?

No, Certine is not a laxative.

How should I take Certine?

Certine should be taken with or without food as prescribed by a doctor. It is important to take Certine exactly as prescribed and not to take more or less than recommended.

Can I take Certine long-term?

Certine can be taken long-term if it is necessary and advised by your doctor. It may be necessary to take Certine long-term to treat certain conditions, such as Zollinger-Ellison Syndrome.

What foods should I avoid while taking Certine?

It is recommended to avoid eating any food that increases the production of acid in the stomach, such as alcohol, caffeine, spicy foods, and citrus fruits while taking Certine.

Can Certine cause weight gain?

No, there is no evidence to suggest that Certine is linked to weight gain.

Can I take Omeprazole and Certine together?

No, it is not recommended to take Omeprazole and Certine together as they are both H2 blockers that work by suppressing acid production in the stomach.

Can I take vitamin C while taking Certine?

Yes, it is safe to take vitamin C while taking Certine.

Does Certine raise blood pressure?

No, there is no evidence to suggest that Certine is linked to increased blood pressure.

Can I take Certine if I have diabetes?

Yes, it is safe to take Certine if you have diabetes.

Can I take ibuprofen and Certine together?

Yes, it is safe to take ibuprofen and Certine together.

Can I take aspirin and Certine together?

Yes, it is safe to take aspirin and Certine together.

Does Certine cause constipation?

Yes, Certine can cause constipation in some people. If you experience constipation while taking Certine, it is important to contact your doctor.

Can I take Pepto-Bismol and Certine together?

No, it is not recommended to take Pepto-Bismol and Certine together as they both contain bismuth, which can have adverse effects when taken together.

What is the best time of day to take Certine?

The best time of day to take Certine depends on the dosage prescribed by your doctor. However, as a general rule, it is best to take the medication after meals or before bedtime.

Can I take Axid and Certine together?

No, it is not recommended to take Axid and Certine together as they both contain similar active ingredients and can lead to an overdose.

Can Certine cause liver damage?

Certine is not known to cause liver damage; however, if you notice any signs or symptoms of liver damage, it is important to contact your doctor immediately.

Can I take synthroid and Certine together?

Yes, it is safe to take synthroid and Certine together.

Does Certine cause weight loss?

No, there is no evidence to suggest that Certine is linked to weight loss.

Can Certine increase anxiety?

Yes, Certine can increase anxiety in some people. If you experience anxiety while taking Certine, it is important to contact your doctor.

Can Certine cause diarrhea?

Yes, Certine can cause diarrhea in some people. If you experience diarrhea while taking Certine, it is important to contact your doctor.

Can I take Prilosec and Certine together?

No, it is not recommended to take Prilosec and Certine together as they both contain similar active ingredients and can lead to an overdose.

Can I take phentermine and Certine together?

Yes, it is safe to take phentermine and Certine together.

Can I take smellaid and Certine together?

Yes, it is safe to take smellaid and Certine together.

Can I take Zofran and Certine together?

Yes, it is safe to take Zofran and Certine together.

Can I take Allegra and Certine together?

Yes, it is safe to take Allegra and Certine together.

Can I take a multivitamin and Certine together?

Yes, it is safe to take a multivitamin and Certine together.

Can I take Tagamet and Certine together?

No, it is not recommended to take Tagamet and Certine together as they both contain similar active ingredients and can lead to an overdose.

Can Certine cause stomach pain?

Yes, Certine can cause stomach pain in some people. If you experience stomach pain while taking Certine, it is important to contact your doctor.

Can I take ibuprofen and Certine at the same time?

Yes, it is safe to take ibuprofen and Certine at the same time.

Can I take aspirin and Certine at the same time?

Yes, it is safe to take aspirin and Certine at the same time.

Can Certine cause headaches?

Yes, Certine can cause headaches in some people. If you experience headaches while taking Certine, it is important to contact your doctor.

Can I take Benadryl and Certine together?

Yes, it is safe to take Benadryl and Certine together.

Can I take Tylenol and Certine together?

Yes, it is safe to take Tylenol and Certine together.

Can I take Prevacid and Certine together?

No, it is not recommended to take Prevacid and Certine together as they both contain similar active ingredients and can lead to an overdose.

Can I take Certine and Pepcid AC together?

No, it is not recommended to take Certine and Pepcid AC together as they both contain similar active ingredients and can lead to an overdose.

Can Certine cause dizziness?

Yes, Certine can cause dizziness in some people. If you experience dizziness while taking Certine, it is important to contact your doctor.