Cellulose Carboxymethyl Ether

Cellulose Carboxymethyl Ether Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cellulose Carboxymethyl Ether is a brand name. Its generic name is Carboxymethylcellulose.

Cellulose Carboxymethyl Ether (CMC)

Cellulose Carboxymethyl Ether (CMC) is an anionic cellulose-based product derived from cellulose, which is usually obtained from plants. It is a white powdery substance that dissolves in cold and hot water and forms a translucent viscous liquid.

Uses

Cellulose Carboxymethyl Ether (CMC) is used in many industries. It is commonly used in the food industry as a thickener and stabilizer for beverages, jams, sauces, salad dressings, yogurt, ice cream, and many other food items. It can be used in eye drops as an artificial tear, and is also used in pharmaceutical and personal care preparations such as toothpaste, hand soaps, and shower gels.

Mechanism of Action

Cellulose Carboxymethyl Ether (CMC) is an anionic polymer that combines with various compounds to form complexes. These complexes increase the viscosity of the solution which helps in thickening and emulsification of various products. It is also used to improve the stability of surfactants, which helps in preventing separation and improving clarity of food products.

How Long Does it Take to Work?

Generally, it takes a few minutes for carboxymethylcellulose (CMC) to take effect. However, the exact time required can vary depending on the product it is used in.

Absorption

Cellulose Carboxymethyl Ether (CMC) is not absorbed by the body and passes out of the digestive system unchanged.

Route of Elimination

Cellulose Carboxymethyl Ether (CMC) is not absorbed or metabolized by the body and is eliminated in the feces.

Dosage

There is no standard dosage for carboxymethylcellulose (CMC). The amount depends on the product type and its intended use. Generally, CMC is used in low concentrations in food and personal care products usually in the range of 0.1%-10%. For pharmaceutical uses, the concentration can be up to much higher up to 99%.

Administration

Cellulose Carboxymethyl Ether (CMC) is often used in food and personal care products as a thickening and stabilizing agent. It is usually added in the form of a powder or a solution and mixed in with other ingredients. For pharmaceutical uses, it is usually administered orally or intravenously as an oral or liquid solution.

Side Effects

Cellulose Carboxymethyl Ether (CMC) is generally regarded as safe and non-toxic. In some people, it may cause mild gastrointestinal discomfort such as nausea and bloating. It may also cause allergic reactions in some people.

Toxicity

Cellulose Carboxymethyl Ether (CMC) is not considered to be toxic at low concentrations. Acute oral toxicity studies in animals showed that CMC was non-toxic and no adverse effects were observed when it was administered at a dose of up to 4700mg/kg of body weight.

Precautions

Cellulose Carboxymethyl Ether (CMC) should not be used in people with known hypersensitivity or allergy to carboxymethylcellulose or other cellulose derivatives. It should also be used with caution in people suffering from gastrointestinal conditions such as constipation or fecal impaction.

Interactions

Cellulose Carboxymethyl Ether (CMC) may interact with other medications or supplements, including antibiotics, antacids, laxatives, diuretics, and some vitamin and mineral supplements. It should be used with caution in patients taking other medications, or in combination with other drugs or supplements.

Disease Interactions

Cellulose Carboxymethyl Ether (CMC) may interact with certain diseases or conditions. It should be used with caution in people with diabetes, as it may increase the risk of low blood sugar or hypoglycemia. It should also be used with caution in people with a history of gastrointestinal conditions, as it may worsen constipation.

Drug Interactions

Cellulose Carboxymethyl Ether (CMC) may interact with certain drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), antacids, antibiotics, antidiabetic medications, and diuretics. It should be avoided in patients taking these drugs.

Food Interactions

Cellulose Carboxymethyl Ether (CMC) does not interact with food. However, it may interfere with the absorption of certain medications and supplements if taken at the same time.

Pregnancy Use

Cellulose Carboxymethyl Ether (CMC) is not recommended for pregnant or breastfeeding women, as its safety in these populations has not been established. If it is used during pregnancy or breastfeeding, it should be used with caution under the guidance of a healthcare professional.

Lactation Use

Cellulose Carboxymethyl Ether (CMC) is not recommended for breastfeeding women, as its safety in this population is yet to be established. If it is used during breastfeeding, it should be used with caution under the guidance of a healthcare professional.

Acute Overdose

Cellulose Carboxymethyl Ether (CMC) is not toxic and no adverse effects have been observed in animal studies. There is no evidence of an acute toxic effect from overdose. However, if an overdose has occurred, it is important to seek medical attention.

Contraindications

Cellulose Carboxymethyl Ether (CMC) is contraindicated in people with known hypersensitivity or allergy to carboxymethylcellulose or other cellulose derivatives. It should also be used with caution in people with a history of gastrointestinal conditions, as it may worsen constipation.

Use Direction

Cellulose Carboxymethyl Ether (CMC) is used in a variety of products and applications. Generally, it can be used at concentrations of 0.1%-10%, and up to 99% for pharmaceutical uses. It is usually added in the form of a powder or a solution and mixed in with other ingredients.

Storage Condition

Cellulose Carboxymethyl Ether (CMC) should be stored in an airtight container in a cool, dry place. It should not be exposed to moisture and extreme temperatures.

Volume of Distribution

Cellulose Carboxymethyl Ether (CMC) is not absorbed by the body and is not distributed in the body.

Half Life

Cellulose Carboxymethyl Ether (CMC) is not metabolized by the body and therefore does not have a half-life.

Clearance

Cellulose Carboxymethyl Ether (CMC) is not cleared from the body as it is not absorbed into the bloodstream.

Here you find in details version of Cellulose Carboxymethyl Ether

Some Frequently Asked Questions About Cellulose Carboxymethyl Ether

What is Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) is a form of cellulose that has been modified with carboxymethyl groups. It is a white, odorless, and tasteless powder often used as a thickener, emulsifier, water binder, and film former in food products.

What is Cellulose Carboxymethyl Ether used for?

Cellulose Carboxymethyl Ether is used as a food additive, pharmaceutical additive, and in pharmaceutical products. It is used as a thickening agent, emulsifier, stabilizer, and water binder in food products. It is also used as a tablet binder and as a suspending agent in pharmaceuticals.

What is the general chemical structure of Cellulose Carboxymethyl Ether?

The general chemical structure of Cellulose Carboxymethyl Ether (CMC) is a linear chain of glucose units in which each carbon on the glucose is hydrogen bonded to a carboxymethyl group (CH3COO-). This structure provides a high level of uniformity and resistance to degradation.

How is Cellulose Carboxymethyl Ether made?

Cellulose Carboxymethyl Ether (CMC) is made by treating cellulose (plant material) with a reagent containing a carboxymethyl group for a period of time. This treatment leads to the introduction of carboxymethyl groups into the cellulose chain. The product produced is referred to as CMC or modified cellulose.

What is the molecular weight of Cellulose Carboxymethyl Ether?

The molecular weight of Cellulose Carboxymethyl Ether (CMC) is variable, depending on the degree of substitution (Degree of Substitution = number of substituents attached to cellulose/number of hydroxyl groups available to be replaced). Generally, CMC molecules range from 5,000-500,000 g/mol.

What is the melting point of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) does not have a specific melting point as it is a polymeric substance. The thermal and physical properties of the particular substitution level or grade may affect the type of thermal transition that occurs.

How is Cellulose Carboxymethyl Ether used in food?

Cellulose Carboxymethyl Ether (CMC) is used as a thickener, emulsifier, stabilizer, and water binder in a variety of food products. It can be used to thicken soups, sauces, and gravies; stabilize desserts; and bind water in bakery products.

What are the properties of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether has many properties such as good film-forming and gelling properties, viscosity stability, ability to stabilise foam, water binding and water solubility. It also has good heat and shear resistance, enables control of product consistency, high pH stability and low toxicity.

What are the advantages of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether has many advantages over other additives, including its high viscosity, low production cost, low toxicity, broad temperature, pH and shear stability, and its ability to form strong films. It is also easy to use, non-allergenic and can be used in both hot and cold applications.

What is the solubility of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) has good solubility in cold water and some hot water solutions, depending on the substituents of the cellulose. For instance, derivatives containing sulfate or carboxylate ions are more soluble in hot water than derivatives with methoxy groups.

Is Cellulose Carboxymethyl Ether non-toxic?

Cellulose Carboxymethyl Ether (CMC) is generally non-toxic and is approved for use as a food additive in many countries. It is also approved for use in food contact materials and has been recognized as safe for human consumption.

What is the stability of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) is stable over a wide range of pH and temperatures up to 100°C. It is also resistant to shear, making it a good choice for use in food and cosmetic products.

What is the viscosity of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) can have a very high viscosity depending on its level of substitution and degree of hydration. CMC is often used as a viscosity stabilizer at low temperature and concentration.

What is the emulsifying property of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) has excellent emulsifying properties due to its ability to form a film around droplets of oil or fat. This film reduces the interfacial tension between the particles of oil, which makes them easier to disperse and gives a stable emulsion.

Is Cellulose Carboxymethyl Ether vegan?

Yes, Cellulose Carboxymethyl Ether (CMC) is a vegan ingredient, as it is derived from plants. It is also kosher certified.

What is the pH range of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) is stable over a wide pH range, ranging from 1 to 10. It can be used in acidic or basic applications without any significant changes in its properties.

Does Cellulose Carboxymethyl Ether need to be refrigerated?

Cellulose Carboxymethyl Ether (CMC) does not need to be refrigerated. It is a stable substance and can be stored at room temperature.

What is the shelf life of Cellulose Carboxymethyl Ether?

The shelf life of Cellulose Carboxymethyl Ether (CMC) depends on its grade and level of substitution, but generally it can be stored for up to several years in room temperature, in a dry and properly sealed container.

What is the difference between Cellulose Carboxymethyl Ether and Cellulose?

Cellulose Carboxymethyl Ether (CMC) is a form of cellulose (plant material) in which part of the carbohydrates in the cellulose chain have been replaced by carboxymethyl groups. This makes CMC more soluble and stable than cellulose.

Does Cellulose Carboxymethyl Ether contain gluten?

No, Cellulose Carboxymethyl Ether (CMC) does not contain any gluten as it is derived from plants and does not contain any wheat, rye, barley, or other gluten-containing grains.

Does Cellulose Carboxymethyl Ether need to be pre-hydrated?

Yes, Cellulose Carboxymethyl Ether (CMC) usually needs to be pre-hydrated prior to being mixed into a solution or formulation. Pre-hydration allows CMC to dissolve more easily and evenly in the solution.

How is Cellulose Carboxymethyl Ether dissolved in solutions?

To dissolve Cellulose Carboxymethyl Ether (CMC) in solutions, it must first be pre-hydrated in cold water or other polar solvent, before adding it to the formulation. Mixing at a low shear rate and a low concentration can also help with dissolution.

Can Cellulose Carboxymethyl Ether degrade over time?

Yes, Cellulose Carboxymethyl Ether (CMC) can degrade over time due to environmental factors such as the presence of oxygen and light. Controlling the storage conditions such as the storage temperature and relative humidity can help reduce the degradation of CMC.

What is the solubility limit of Cellulose Carboxymethyl Ether?

The solubility of Cellulose Carboxymethyl Ether typically increases with increase in the level of substitution and hydrogen bond formation. The solubility limit of CMC generally decreases with increasing temperature or pH, depending on the particular derivative.

What are the different grades of Cellulose Carboxymethyl Ether available?

Cellulose Carboxymethyl Ether is available in different grades of substitution and molecular weights. Low substitution grades are typically used in food products, while higher substitution grades are often used in industrial applications.

Can Cellulose Carboxymethyl Ether be used in aqueous solutions?

Yes, Cellulose Carboxymethyl Ether can be used in aqueous solutions as it has good water-binding properties and can control the viscosity of the solution. It is also temperature- and pH-stable and has good shear resistance.

What is the difference between Cellulose Carboxymethyl Ether and Hydroxypropylcellulose?

Cellulose Carboxymethyl Ether (CMC) is a form of cellulose with carboxymethyl groups in its chain, while Hydroxypropylcellulose (HPC) is a form of cellulose in which hydroxypropyl groups have been inserted in the chain. Both are often used as thickeners and stabilizers in products such as pharmaceuticals and food products.

What does Degree of Substitution (DS) mean?

The degree of substitution (DS) of Cellulose Carboxymethyl Ether (CMC) is the average number of carboxymethyl groups per glucose unit in the cellulose chain. It is an important factor in determining the properties and applications of CMC.

What are the applications of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) has a wide range of applications including use in food and pharmaceutical products as a thickener, emulsifier, stabilizer, water binder, and film-former. It is also used in the oil industry for drilling fluids and fracturing fluids, in the paper industry, and in adhesives, coatings and textile pastes.

What is the boiling point of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) does not have an exact boiling point as it is a polymeric substance. However, the thermal and physical properties of the particular substitution level or grade may affect the type of thermal transition that occurs.

What is the plastics compatibility of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) is generally compatible with most plastics. However, some grades of CMC can reduce the strength of plastic films due to the plasticizer effect of the CMC.

Does Cellulose Carboxymethyl Ether need to be acid-neutralized?

Cellulose Carboxymethyl Ether (CMC) typically does not need to be acid-neutralized, but it can be beneficial to do so in certain formulations in order to increase its solubility or improve its thermal stability.

What are the regulatory approvals of Cellulose Carboxymethyl Ether?

Cellulose Carboxymethyl Ether (CMC) is approved for use as a food additive in many countries. It is also approved for use in food contact materials and has been recognized as safe for human consumption.

Can Cellulose Carboxymethyl Ether be used in topical applications?

Yes, Cellulose Carboxymethyl Ether (CMC) can be used in topical applications such as creams, lotions, gels and ointments. It has good film-forming properties, and its water-binding properties can help maintain skin hydration in the product.

How is Cellulose Carboxymethyl Ether removed from a formulation?

Cellulose Carboxymethyl Ether (CMC) can be removed from a formulation by decreasing the pH or by adding an ionic or nonionic surfactant. It is important to use compatible surfactants that will not affect the physical properties of the formulation.

What is the effect of temperature on Cellulose Carboxymethyl Ether?

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