Cefoperazone/Sulbactam
Cefoperazone/Sulbactam Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cefoperazone/Sulbactam is a brand name. Its generic name is Cefoperazone.
Introduction
Cefoperazone/Sulbactam is a semi-synthetic third-generation cephalosporin antibiotic which is used as an anti-infective beta-lactam antibiotic drug. It is used alone or in combination with other antibiotics.Uses
Cefoperazone/Sulbactam is typically used to treat certain bacterial infections, such as pneumonia, urinary tract infections, skin and soft-tissue infections, and others. It is also used to treat and prevent certain fungal infections.Mechanism of Action
Cefoperazone/Sulbactam works by inhibiting the growth of certain bacteria and fungi. It does this by binding to the penicillin-binding proteins in the bacterial cell wall, preventing the bacteria from building and repair their cell wall, which ultimately causes their death.How Long Does It Take to Work?
The effectiveness of cefoperazone usually depends on the type and severity of the infection. In general, it usually takes 2 to 3 days to show the effects of the medicine, and it may take several weeks for the infection to completely resolve.Absorption
Cefoperazone/Sulbactam is rapidly absorbed from the gastrointestinal tract and streptococci are most sensitive to it.Route of Elimination
Cefoperazone/Sulbactam is eliminated primarily through the kidneys via renal excretion, although some of it is eliminated in the bile and feces.Dosage
The dosage of cefoperazone depends on the type of infection being treated and the weight and age of the patient.- For adults, the usual dosage is 500 mg to 1 g, every 6 to 8 hours.
- For children, the dosage is usually 25 to 50 mg/kg body weight, every 8 to 12 hours.
- For newborns and premature babies, the dosage is 5 to 10 mg/kg body weight, every 12 hours.
Administration
Cefoperazone/Sulbactam should be taken orally or by injection. When given by injection, it should be administered slowly over 3–5 minutes. It should never be given intramuscularly.Side Effect
The most common side effects of taking cefoperazone include nausea, vomiting, diarrhea, headaches, abdominal pain, dizziness, and rash.Toxicity
Cefoperazone/Sulbactam can be toxic if taken in high doses or for a prolonged period of time. Symptoms of toxicity include hepatitis, seizures, and cardiac arrest.Precautions
Before taking cefoperazone, it is recommended to tell your doctor about:- Any allergies you have.
- If you have ever had kidney, liver, or heart problems.
- If you are pregnant or breastfeeding.
- If you are taking any other prescription or over-the-counter medication.
- If you have ever had any kind of allergies.
Interactions
Cefoperazone/Sulbactam can interact with other medications, such as anticoagulants, anticonvulsants, proton pump inhibitors, and sulfonylureas. Therefore, it is important to tell your doctor about any other medication you are taking before taking cefoperazone.Disease Interaction
Cefoperazone/Sulbactam may increase the risk of bleeding if taken with certain medical conditions, including liver disease, kidney disease, and bleeding disorders.Drug Interaction
Cefoperazone/Sulbactam may interact with certain other medications. It is important to tell your doctor about any other medications you are taking before taking cefoperazone.Food Interactions
No food interactions have been reported.Pregnancy Use
Cefoperazone/Sulbactam should not be used during pregnancy unless it is absolutely necessary.Lactation Use
Cefoperazone/Sulbactam should not be used during lactation unless it is absolutely necessary.Acute Overdose
Symptoms of an acute overdose of cefoperazone include abdominal pain, nausea, vomiting, diarrhea, thrombocytopenia, and convulsions.Contraindication
Cefoperazone/Sulbactam should not be used if you are allergic to any cephalosporin antibiotics, such as cefadroxil or cephalexin.Use Direction
Cefoperazone/Sulbactam should be taken as directed by your doctor and according to the instructions on the medication label.Storage Condition
Cefoperazone/Sulbactam should be stored at room temperature, away from moisture and heat.Volume of Distribution
Cefoperazone/Sulbactam has an apparent volume of distribution of 0.14 L/kg.Half-Life
The half-life of cefoperazone is approximately 1 hour.Clearance
Cefoperazone/Sulbactam has an apparent clearance of 0.06 L/kg/hr.Here you find in details version of Cefoperazone/Sulbactam
Some Frequently Asked Questions About Cefoperazone/Sulbactam
What is Cefoperazone/Sulbactam?
Cefoperazone/Sulbactam is a type of cephalosporin antibiotic. Cefoperazone/Sulbactam is used to kill bacteria that causes various types of infections.
What is the generic name of Cefoperazone/Sulbactam?
Cefoperazone/Sulbactam is the generic name for the brand name drug Cefobid.
What is Cefoperazone/Sulbactam used for?
Cefoperazone/Sulbactam is used to treat a variety of bacterial infections, including bladder infections, pneumonia, meningitis, and other less common bacterial infections.
What is the recommended dosage of Cefoperazone/Sulbactam?
The recommended dosage of Cefoperazone/Sulbactam depends on the type of infection and severity, as well as other factors such as the patient's age and weight. It is important to follow the doctor's instructions for the correct dosage.
What are the side effects of Cefoperazone/Sulbactam?
The most common side effects of Cefoperazone/Sulbactam include headache, nausea, rash, and diarrhea. Other potential side effects include itching, dizziness, insomnia, and joint and muscle pain.
Can Cefoperazone/Sulbactam be used to treat a urinary tract infection?
Yes, Cefoperazone/Sulbactam is an antibiotic that can be used to treat a urinary tract infection.
Is Cefoperazone/Sulbactam safe to take during pregnancy?
If you are pregnant or nursing, you should speak with your doctor before taking Cefoperazone/Sulbactam as it may not be safe for use during pregnancy.
Is Cefoperazone/Sulbactam considered a penicillin antibiotic?
No, Cefoperazone/Sulbactam is not a type of penicillin antibiotic.
Can Cefoperazone/Sulbactam be used to treat a sinus infection?
Yes, Cefoperazone/Sulbactam can be used to treat a sinus infection as long as the infection is caused by certain types of bacteria.
Does Cefoperazone/Sulbactam cause weight gain?
Weight gain is not a known side effect of Cefoperazone/Sulbactam.
Does Cefoperazone/Sulbactam interact with any other medications?
Yes, Cefoperazone/Sulbactam can interact with some other medications such as antacids and birth control pills. Be sure to tell your doctor about all medications and supplements you are taking to avoid any potential interactions.
Can Cefoperazone/Sulbactam be used to treat a skin infection?
Yes, Cefoperazone/Sulbactam can be used to treat certain types of skin infections caused by certain types of bacteria.
What should I do if I forget to take a dose of Cefoperazone/Sulbactam?
If you forget to take a dose of Cefoperazone/Sulbactam, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time.
Can I drink alcohol while taking Cefoperazone/Sulbactam?
No, it is not recommended to drink alcohol while taking Cefoperazone/Sulbactam as alcohol can increase the risk of side effects.
What are some potential drug interactions with Cefoperazone/Sulbactam?
Cefoperazone/Sulbactam can interact with other medications such as warfarin, aspirin, and diuretics, as well as other antibiotics. Make sure to tell your doctor about all medications and supplements you are taking to avoid any potential interactions.
Can Cefoperazone/Sulbactam be used to treat a strep throat infection?
Yes, Cefoperazone/Sulbactam can be used to treat a strep throat infection as long as the infection is caused by certain types of bacteria.
Can Cefoperazone/Sulbactam be used to treat a bladder infection?
Yes, Cefoperazone/Sulbactam can be used to treat bladder infections caused by certain types of bacteria.
Can Cefoperazone/Sulbactam be used to treat a kidney infection?
Yes, Cefoperazone/Sulbactam can be used to treat a kidney infection as long as the infection is caused by certain types of bacteria.
Can Cefoperazone/Sulbactam be used to treat a yeast infection?
No, Cefoperazone/Sulbactam is not effective against fungal infections such as yeast infections.
Can I take Cefoperazone/Sulbactam with ibuprofen?
Yes, you can take Cefoperazone/Sulbactam with ibuprofen if advised by your doctor. However, it is important to make sure you do not exceed the recommended dosage of either medication.
How long does it take for Cefoperazone/Sulbactam to start working?
The effects of Cefoperazone/Sulbactam can be noticed within a couple of days or up to a week, depending on the type of infection and severity.
Can Cefoperazone/Sulbactam be used to treat a sinus infection?
Yes, Cefoperazone/Sulbactam can be used to treat a sinus infection as long as the infection is caused by certain types of bacteria.
How long should I take Cefoperazone/Sulbactam?
The length of time you should take Cefoperazone/Sulbactam depends on the type of infection and severity. It is important to follow your doctor's instructions and finish the entire course of the medication.
Can I take Cefoperazone/Sulbactam with Tylenol?
Yes, you can take Cefoperazone/Sulbactam with Tylenol as long as you do not exceed the recommended dose of either medication.
Does Cefoperazone/Sulbactam cause drowsiness?
Drowsiness is a potential side effect of Cefoperazone/Sulbactam. If you experience drowsiness, it is important to not drive or operate heavy machinery until the effects wear off.
Can Cefoperazone/Sulbactam be used to treat bronchitis?
Yes, Cefoperazone/Sulbactam can be used to treat certain types of bronchitis caused by certain types of bacteria.
How should Cefoperazone/Sulbactam be stored?
Cefoperazone/Sulbactam should be stored at room temperature away from moisture, light, and heat. It is important to keep it in a tight, light-resistant container.
Can I take Cefoperazone/Sulbactam with food?
Yes, you can take Cefoperazone/Sulbactam with or without food. However, it is important to take it with a full glass of water.
Does Cefoperazone/Sulbactam have any drug interactions with vitamins and supplements?
Yes, Cefoperazone/Sulbactam can interact with some vitamins and supplements. Be sure to tell your doctor about all vitamins and supplements you are taking to avoid any potential interactions.
Is Cefoperazone/Sulbactam safe for children?
Yes, Cefoperazone/Sulbactam is safe for use in children as long as it is taken at the recommended dosage.
What are the signs of an allergic reaction to Cefoperazone/Sulbactam?
Signs of an allergic reaction to Cefoperazone/Sulbactam include swelling of the face, lips, throat, or tongue; difficulty breathing; itching or hives; rash; and lightheadedness. If you experience any of these symptoms, stop taking Cefoperazone/Sulbactam and contact your doctor immediately.
Can Cefoperazone/Sulbactam cause stomach upset?
Yes, stomach upset is a common side effect of Cefoperazone/Sulbactam. It is important to drink plenty of fluids and eat small, light meals to help prevent stomach upset.
Does Cefoperazone/Sulbactam interact with any other antibiotics?
Yes, Cefoperazone/Sulbactam can interact with other antibiotics such as ciprofloxacin, erythromycin, and amoxicillin. Be sure to tell your doctor about all medications and supplements you are taking to avoid any potential interactions.
Can Cefoperazone/Sulbactam be used to treat a urinary tract infection?
Yes, Cefoperazone/Sulbactam is an antibiotic that can be used to treat a urinary tract infection.
Can I take Cefoperazone/Sulbactam if I am pregnant?
If you are pregnant or nursing, you should speak with your doctor before taking Cefoperazone/Sulbactam as it may not be safe for use during pregnancy.
Does Cefoperazone/Sulbactam cause constipation?
Constipation is a potential side effect of Cefoperazone/Sulbactam. It is important to drink plenty of fluids and eat high-fiber foods to help prevent constipation.
Can Cefoperazone/Sulbactam be used to treat an abscess?
Yes, Cefoperazone/Sulbactam can be used to treat an abscess caused by certain types of bacteria.
Does Cefoperazone/Sulbactam interact with any other medications?
Yes, Cefoperazone/Sulbactam can interact with some other medications such as antacids and birth control pills. Be sure to tell your doctor about all medications and supplements you are taking to avoid any potential interactions.
Can Cefoperazone/Sulbactam be used to treat an ear infection?
Yes, Cefoperazone/Sulbactam can be used to treat certain types of ear infections caused by certain types of bacteria.
Does Cefoperazone/Sulbactam cause dry mouth?
Yes, dry mouth is a potential side effect of Cefoperazone/Sulbactam. It is important to drink plenty of fluids to help prevent dry mouth.
Can Cefoperazone/Sulbactam be used to treat an abscessed tooth?
Yes, Cefoperazone/Sulbactam can be used to treat an abscessed tooth caused by certain types of bacteria.
Can Cefoperazone/Sulbactam be used to treat a lung infection?
Yes, Cefoperazone/Sulbactam can be used to treat certain types of lung infections caused by certain types of bacteria.
Does Cefoperazone/Sulbactam cause diarrhea?
Yes, diarrhea is a common side effect of Cefoperazone/Sulbactam. It is important to drink plenty of fluids and avoid foods that may worsen diarrhea.