Carboprost
Carboprost Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Carboprost is a brand name. Its generic name is Carboprost Tromethamine.
Introduction
Carboprost (also known as Prostin VR Pediatric) is a synthetic analogue of the naturally occurring hormone prostaglandin F2α. It is commonly used in medical settings for the treatment of uterine tonus and cervical ripening, induction of labor, and the treatment of incomplete or inevitable abortion.Uses for
Carboprost is most commonly used as an abortifacient to terminate pregnancy. It has been used safely in medical settings for decades and is the most common medication for early pregnancy termination. It is also used to induce labor and to help move along labor that is progressing too slowly. In addition, it can be used for the treatment of severe bleeding after delivery or miscarriage.Mechanism of Action
Carboprost works by inducing contraction of the uterus in order to end pregnancy and move labor along. It binds to specific prostaglandin F receptors that are located on the surface of uterine cells. This binding stimulates the cells to contract, which eventually leads to expulsion of the fetus.How Long Does It Take To Work?
Carboprost generally takes effect within 30 to 120 minutes after administration. In some cases, it can take up to 24 hours to show full effects.Absorption
Carboprost is rapidly absorbed from the gastrointestinal tract. Its bioavailability is approximately 95%.Route of Elimination
Carboprost is quickly eliminated from the body, with a half-life of only about 4 minutes. It is mainly eliminated via the urine in the form of metabolites.Dosage
The recommended dose of Carboprost is 250 mcg intramuscularly every 90 minutes. In the case of uterine atony, the dose can be increased to 500 mcg.Administration
Carboprost should be administered intramuscularly only. It should not be given intravenously as it can cause severe tissue damage.Side Effect
Common side effects of Carboprost include nausea, vomiting, abdominal pain, diarrhea, and headache. Other more severe side effects may include itching, hives, and rash.Toxicity
Carboprost is generally well tolerated and has a wide safety margin. Serious adverse reactions are rare, and it is generally considered to have low toxicity.Precaution
Carboprost should be used with caution in patients with renal or hepatic impairment, as these patients may experience increased toxicity. It should not be used in patients who are pregnant, as it may cause fetal death.Interaction
Carboprost should not be taken with any other medications that reduce or increase uterine tone, such as prostaglandin E1, oxytocin, or misoprostol. It should also not be taken with any medications that affect hypothalamic and pituitary activity, such as corticosteroids.Disease Interaction
Carboprost should not be used in patients with a known hypersensitivity to the drug or to any of the excipients present in the formulation. It should also not be used in patients with active sickle cell anemia, as it may cause complications.Drug Interaction
Carboprost is known to interact with several other drugs, including anticoagulants, diuretics, and oral contraceptives. It should not be used in combination with these drugs, as it may increase their effects or cause serious side effects.Food Interactions
Carboprost should not be taken with high-fat meals or grapefruit juice, as these may decrease its absorption and effectiveness.Pregnancy Use
Carboprost should not be used during pregnancy, as it may cause fetal death.Lactation Use
Carboprost should not be used during lactation, as it may cause serious side effects in nursing infants.Acute Overdose
In the case of an acute overdose, supportive supportive measures should be taken and medical attention sought immediately.Contraindication
Carboprost should not be used in patients with known hypersensitivity to the drug or to any of the excipients present in the formulation. It should also not be used in patients with active sickle cell anemia, as it may cause complications.Use Directions
Carboprost should be administered intramuscularly only. Care should be taken to avoid intravascular injection, as it can cause serious tissue damage. The recommended dose of Carboprost is 250 mcg intramuscularly every 90 minutes.Storage Condition
Carboprost should be stored at room temperature, away from light and moisture. It should be kept out of reach of children and pets.Volume of Distribution
The volume of distribution of Carboprost is approximately 1.2 L/kg.Half Life
The half-life of Carboprost is approximately 4 minutes.Clearance
The clearance of Carboprost is approximately 12 mL/min/kg.Here you find in details version of Carboprost
Some Frequently Asked Questions About Carboprost
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