Bimator
Bimator Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Bimator is a brand name. Its generic name is Bimatoprost + Timolol.
Introduction
Bimator is a medication used to treat glaucoma and for the treatment of open angle glaucoma and ocular hypertension in adults. It contains a combination of bimatoprost and timolol maleate, two powerful medications that work together to lower intraocular pressure (IOP). It works by reducing the amount of fluid produced in the eye and increasing the outflow of fluid from the eye. The combination of these effects results in a decrease in intraocular pressure.
Uses
Bimator is used to treat glaucoma and ocular hypertension in adults. It helps reduce intraocular pressure, which can lead to vision loss.
Mechanism of Action
Bimator is a combination medication that works to reduce intraocular pressure in glaucoma. It contains bimatoprost, a medication that works by reducing the production of fluid in the eye, and timolol maleate, which increases the outflow of fluid from the eye. The combination of these two medications leads to a decrease in intraocular pressure, which helps prevent vision loss.
How Long Does It Take to Work?
Bimator usually takes several weeks to have its full effect. The decrease in intraocular pressure may be noticeable within a few days, but the full benefits may take 3-6 weeks to be achieved.
Absorption
Bimator is both a topical ophthalmic solution and an eye drop for the treatment of glaucoma. Bimatoprost is absorbed into the ocular tissue and then into the bloodstream. Timolol is absorbed in the ocular tissue, where it binds to receptors which block the production of fluid in the eye.
Route of Elimination
Both bimatoprost and timolol are eliminated primarily in the urine. Bimatoprost is metabolized by the liver and broken down into its active metabolite, and timolol is primarily metabolized in the liver.
Dosage
The dose of Bimator is one drop ophthalmic solution in each affected eye once daily. It is typically well-tolerated and is usually effective in controlling intraocular pressure.
Administration
Bimator ophthalmic solution is administered once daily. It should be instilled directly into the affected eye(s), by pulling down the lower lids and placing the eye dropper into the eye. After instilling, close the eyes for a few minutes to allow the medication to be absorbed.
Side Effects
Some of the common side effects of Bimator include eye itching and irritation, redness of the eyes, change in eye color, blurred vision, dry eyes, and eyelash growth. Serious side effects may include slowed or irregular heartbeat, chest pain, or difficulty breathing.
Toxicity
Bimator has not been reported to be toxic at therapeutic doses. However, if swallowed, seek medical attention or contact a Poison Control Center immediately.
Precautions
Bimator should not be used if you are allergic to any of its ingredients. Patients with a history of active intraocular inflammation, certain serious eye problems, and other medical conditions may not be suitable candidates for this medication. It is important to tell your doctor about all medications and supplements that you are taking to avoid drug interactions.
Interactions
Certain medications can interact with Bimator, including certain antibiotics (e.g. erythromycin), antifungal medications (e.g. ketoconazole), aspirin, and other glaucoma medications (e.g. latanoprost). Tell your doctor about all medications and supplements that you are taking to avoid potential interactions.
Disease Interaction
Bimator may not be suitable for some patients with certain medical conditions. These include certain eye problems, severe asthma, chronic bronchitis, and COPD (chronic obstructive pulmonary disease). Patients with a history of heart disease, kidney or liver problems, or certain rare allergies may also not be suitable for this medication.
Drug Interaction
Certain medications, including certain antibiotics (e.g. erythromycin), antifungal medications (e.g. ketoconazole), aspirin, and other glaucoma medications (e.g. latanoprost) may interact with Bimator and should be avoided. It is important to tell your doctor about all medications and supplements that you are taking to avoid potential interactions.
Food Interactions
Bimator is not known to interact with food. However, it is important to avoid alcohol, as it may increase the side effects of this medication.
Pregnancy Use
Bimator is not recommended for use in pregnant women. Animal studies have not demonstrated any teratogenic effects. The safety and efficacy of this medication in pregnant women has not been established.
Lactation Use
Bimator is not recommended for use in nursing mothers. It is not known if bimatoprost and timolol are excreted in human milk.
Acute Overdose
If an acute overdose of Bimator has been taken, seek immediate medical attention. Symptoms may include chest pain, difficulty breathing, or an irregular heartbeat.
Contraindications
Bimator is contraindicated in patients with a known allergy to bimatoprost or timolol. It is also not recommended for use in patients with certain serious medical conditions, such as heart disease, COPD, active intraocular inflammation, severe asthma, or certain eye problems.
Use Directions
Bimator should be administered as directed by your physician. It should be instilled directly into the affected eye(s), by pulling down the lower lids and placing the eye dropper into the eye. After instilling, close the eyes for a few minutes to allow the medication to be absorbed.
Storage Conditions
Bimator should be stored at room temperature away from direct light and moisture. Do not freeze the medication. Keep it out of the reach of children and pets.
Volume of Distribution
Bimator is widely distributed throughout the body. Bimatoprost is approximately 45% bound to proteins, and timolol is approximately 80% bound.
Half Life
Bimator has a half-life of 13.5 hours. The half-life is the time it takes for the drug to be reduced to half its initial concentration in the body.
Clearance
Bimator is metabolized in the liver by cytochrome P450 3A4 and eliminated primarily in the urine. The clearance of bimatoprost is approximately 0.06 L/h/kg and the clearance of timolol is approximately 2.9 L/h/kg.
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