Belustine
Belustine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Belustine is a brand name. Its generic name is Lomustine.
etcIntroduction and Uses
Belustine (Gleostine, CCNU), is an alkylating agent commonly used in the treatment of brain tumors, cancer, and Hodgkin’s lymphoma. It works by disrupting the DNA of diseased cells, causing them to die. Belustine is usually used in combination with other anticancer drugs.Mechanism of Action
Belustine works by binding to DNA, thus disrupting the structure and causing DNA damage. This leads to an accumulation of altered cells that disrupts the cell’s normal function, resulting in cell death.How Long Does It Take To Work?
It typically takes one to two weeks for lomustine to start working, though it may take longer or shorter depending on a person’s response to the medication.Absorption
Belustine is readily absorbed after oral administration. The bioavailability is approximately 85%.Route of Elimination
Belustine is metabolized in the liver and eliminated quickly in the urine.Dosage
The usual dose of lomustine Capsules is 40 - 100 mg/m2 once every 6 weeks as an intravenous or oral dose. The dose may be adjusted in certain patients.Administration
Belustine can be administered orally or intravenously.Side Effects
Common side effects of lomustine may include nausea, vomiting, diarrhea, fatigue, decreased appetite, hair loss, swelling of the hands and feet, and tingling or numbness in the hands and feet.Toxicity
Belustine can be toxic in high doses. Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal pain, fever, low blood pressure, and seizures.Precautions
Patients taking lomustine should undergo regular blood tests to monitor for any side effects or adverse reactions.Interaction
Belustine may interact with other medications or substances such as herbal products, vitamins, or other drugs.Disease Interaction
Belustine can interact with certain diseases, such as liver or kidney disease, heart disease, or anemia, and should be used with caution in these patients.Drug Interaction
Drug interactions with lomustine may include antibiotics, antifungals, anticonvulsants, antidiabetes drugs, antipsychotics, and chemotherapy drugs.Food Interactions
Belustine should be taken on an empty stomach, and patients should not take it with or after a meal.Pregnancy Use
Belustine is not recommended for pregnant women as it can cause fetal harm.Lactation Use
Belustine is not recommended during breastfeeding.Acute Overdose
Signs and symptoms of an acute overdose may include nausea, vomiting, diarrhea, abdominal pain, fever, and seizures.Contraindication
Belustine is contraindicated in patients with a known hypersensitivity to the drug.Use Direction
Patients should take lomustine exactly as prescribed by their doctor. Missing doses should not be made up and doses should not be taken more often than recommended by your doctor.Storage Conditions
Belustine should be stored at room temperature, away from moisture and heat. It should not be frozen.Volume of Distribution
The volume of distribution of lomustine is approximately 2.2 L/kg.Half Life
The half life of lomustine is approximately 24 hours.Clearance
The clearance of lomustine is 0.87 ml/min/kg.Here you find in details version of Belustine
Some Frequently Asked Questions About Belustine
https://www.medicinesfaq.com/brand/belustine,
http://classyfire.wishartlab.com/tax_nodes/C0000000,
http://classyfire.wishartlab.com/tax_nodes/C0000264,
http://classyfire.wishartlab.com/tax_nodes/C0000364,
http://classyfire.wishartlab.com/tax_nodes/C0000517,
http://classyfire.wishartlab.com/tax_nodes/C0001229,
http://classyfire.wishartlab.com/tax_nodes/C0000114,
http://classyfire.wishartlab.com/tax_nodes/C0003947,
http://classyfire.wishartlab.com/tax_nodes/C0004557,
http://classyfire.wishartlab.com/tax_nodes/C0001516,
http://classyfire.wishartlab.com/tax_nodes/C0003940,
http://classyfire.wishartlab.com/tax_nodes/C0004150,
http://classyfire.wishartlab.com/tax_nodes/C0001831,
http://classyfire.wishartlab.com/tax_nodes/C0001026,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6520,
http://www.hmdb.ca/metabolites/HMDB0015337,
http://www.genome.jp/dbget-bin/www_bget?drug:D00363,
http://www.genome.jp/dbget-bin/www_bget?cpd:C07079,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3950,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506562,
https://www.chemspider.com/Chemical-Structure.3813.html,
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247919,
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6466,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6520,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL514,
https://zinc.docking.org/substances/ZINC000003831006,
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000991,
http://www.pharmgkb.org/drug/PA164749407,
http://www.rxlist.com/cgi/generic2/lomustine.htm,
https://www.drugs.com/cdi/lomustine-ccnu.html,
https://en.wikipedia.org/wiki/Lomustine,