Aspartic Acid
Aspartic Acid Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Aspartic Acid is a brand name. Its generic name is Aspartic acid.
Aspartic Acid
Aspartic Acid, also known as L-aspartic acid, is an organic compound with the formula HOOCCH(NH2)CH2COOH. It is one of the 20 biologically useful amino acids, and an essential component of proteins. It is also a neurotransmitter in the brain where it influences the release and uptake of neurotransmitters, as well as playing an important role in metabolism.
Uses for Aspartic Acid
Aspartic Acid is used in many applications, including pharmaceutical, nutrition, and energy production. In addition, it has been used as a dietary supplement to prevent and treat symptoms of fatigue and stress. It is also used to treat certain medical conditions such as Parkinson's disease and Alzheimer's. Aspartic Acid has also been studied for use in improving athletic performance and preventing muscle atrophy.
Mechanism of Action
As part of the biosynthesis of the neurotransmitter glutamate, aspartic acid is involved in the modulation of neurotransmitter release from pre-synaptic nerve terminals, as well as in the uptake of glutamate by post-synaptic nerve terminals. Aspartic Acid also stimulates the release of calcium from intracellular stores, allowing the nerve cells to respond to an influx of intracellular calcium. This mechanism of action is thought to occur through its interactions with the NMDA receptors.
How Long Does it Take to Work?
The effects of aspartic acid can be felt within minutes of ingestion. It is thought to reach peak concentrations in the brain approximately 2 - 4 hours after ingestion. Its effects will generally last for up to 6-8 hours.
Absorption
Aspartic Acid is rapidly absorbed by the intestine, reaching peak concentrations within two hours of ingestion. The average absorption rate is approximately 20-30%. It is rapidly metabolized and excreted in the urine.
Route of Elimination
Aspartic Acid is rapidly absorbed by the intestine and eliminated via the kidneys. It is eliminated in the urine with a half-life of approximately 5 - 8 hours.
Dosage
The recommended daily dosage for aspartic acid is between 600 - 1500 mg per day, taken in divided doses. It is typically taken two to three times daily. For specific conditions and treatments, different dosages and regimens may be recommended by your health care provider.
Administration
Aspartic Acid can be taken orally or intravenously. Oral administration is typically in the form of tablets, capsules, or powders, and intravenous administration is typically in the form of an infusion. Aspartic Acid can also be administered as injections directly into the bloodstream.
Side Effect
The most common side effects associated with aspartic acid supplementation are nausea, diarrhea, and headache. Other less common side effects include skin irritation, muscle cramps, dizziness, and difficulty sleeping. In rare cases, aspartic acid supplementation has been associated with kidney damage and elevated levels of calcium in the blood.
Toxicity
Aspartic Acid is generally considered to be safe at recommended doses, but excessive doses can lead to serious health complications. Excessive doses of aspartic acid may lead to increased levels of ammonia in the blood, which can be dangerous. Additionally, aspartic acid may lead to elevated levels of calcium in the blood, which can lead to kidney damage.
Precautions
Aspartic Acid should be avoided in individuals with kidney problems or liver diseases. It may also interact with certain medications or interfere with the efficacy of other drugs, so it is important to discuss any supplements you are taking with your doctor. Women who are pregnant or nursing should not take aspartic acid without consulting their doctor first.
Interactions
- Aspartic Acid may interact with certain medications, including those for epilepsy, gout, and high blood pressure.
- It may also interfere with the efficacy of other drugs, including those for Parkinson’s, Alzheimer’s, and HIV AIDS.
- It should not be taken along with other supplements, including magnesium and calcium.
Disease Interaction
Aspartic Acid may interact with certain diseases or medical conditions. It may have interactions with those with epilepsy, gout, and high blood pressure, and should be avoided in individuals with kidney problems or liver diseases.
Drug Interactions
Aspartic Acid may interact with certain drugs, including those for epilepsy, gout, high blood pressure, Parkinson’s, Alzheimer’s, and HIV AIDS. It is important to consult your healthcare provider before taking aspartic acid with any prescription or over-the-counter medications.
Food Interactions
Aspartic Acid should not be taken with foods high in magnesium, calcium, or other minerals and electrolytes as it may interfere with absorption. Additionally, it should not be taken with alcohol or carbonated beverages as it may interfere with its efficacy.
Pregnancy Use
Aspartic Acid should be avoided during pregnancy unless approved by a healthcare provider. Some evidence suggests that it could lead to birth defects, and it should not be taken during the first trimester of pregnancy as it may cause neural tube defects.
Lactation Use
Aspartic Acid should be avoided by breastfeeding mothers unless approved by a healthcare provider. While the effects of aspartic acid on a lactating woman and her infant are not fully known, its use is best avoided until further study is conducted.
Acute Overdose
An acute overdose of aspartic acid can lead to nausea, vomiting, and abdominal pain. If you take an overdose, seek medical attention immediately.
Contraindication
As aspartic acid may interact with certain drugs or interfere with the efficacy of other drugs, it is important to consult your healthcare provider before taking it if you are taking any medications, including those for epilepsy, gout, and high blood pressure.
Usage Directions
Aspartic Acid should be taken as directed by your healthcare provider. The recommended dosage for aspartic acid is between 600 - 1500 mg per day, taken in divided doses. It is typically taken two to three times daily, but your physician may recommend a different dosage and regimen for specific treatments or conditions.
Storage Conditions
Aspartic Acid should be stored in a cool, dry place, and out of reach of children and pets. Keep the container tightly sealed and away from direct light.
Volume of Distribution
Aspartic Acid has a volume of distribution of approximately 5.6 L/Kg. This indicates that it is rapidly absorbed and circulated throughout the body.
Half Life
The half-life of aspartic acid is approximately 5 - 8 hours. This means that after about 8 hours, half of the aspartic acid will have been eliminated from the body.
Clearance
Aspartic Acid has a clearance rate of approximately 50 L/Kg/h. This means that it is rapidly eliminated from the body through renal function within 6-8 hours of ingestion.
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