Alprostadilum
Alprostadilum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Alprostadilum is a brand name. Its generic name is Alprostadil.
Alprostadilum
Alprostadilum is a synthetic prostaglandin E1 that is used to treat erectile dysfunction. It is available in both injectable and intracavernosal forms.
Uses for Alprostadilum
Alprostadilum is most commonly used to treat men who are having difficulty achieving or maintaining an erection. It is also used to treat certain cases of pelvic pain, hypertension, and lack of blood flow to the penis.
Mechanism of Action
Alprostadilum works by increasing the amount of blood flow to the penis, thus aiding in achieving an erection. It does this by relaxing the smooth muscle cells in the penis, which leads to an increase in blood pressure. In addition, alprostadil increases the concentration of nitric oxide. Nitric oxide inhibits phosphodiesterase which increases the release of cGMP, and cGMP causes the smooth muscles in the penis to relax.
How Long Does it Take to Work?
In most cases, the effects of alprostadil can be felt within 10 minutes of injecting the medication. However, this may vary from person to person.
Absorption
The absorption of alprostadil depends on the form of administration. Intracavernosal injection is the most effective and is rapidly absorbed. Alprostadilum is also available as a suppository and can be absorbed by the rectal mucosa. It is also available as a topical cream, which is slowly and incompletely absorbed.
Route of Elimination
Alprostadilum is metabolized predominantly by the liver and is eliminated mainly by the kidneys.
Dosage
The dose of alprostadil depends on the form of administration. The usual dose of the intrapenile injection is 50 mcg to 100 mcg, and the usual dose of the suppository is 125 mcg to 250 mcg. It is also available as a topical cream, and the recommended dose is 50 mcg to 100 mcg.
Administration
Alprostadilum injection should be administered directly into the penis. It is also available as a suppository and should be inserted into the rectal mucosa. Alprostadilum cream should be applied topically to the penis and should be massaged into the skin.
Side Effects
The most common side effects associated with alprostadil are pain, difficulty passing urine, penile redness, and burning sensation. In some cases, prolonged erections may occur.
Toxicity
The toxic effects of alprostadil are mild and rarely occur. However, it may increase the risk of developing Priapism and bleeding in the penis.
Precautions
Patients should be monitored for potential side effects when taking alprostadil. Patients should also tell their doctor about any other medications or supplements they are taking, as they may interact with alprostadil.
Interaction
Alprostadilum may interact with certain medications, such as antifungals and sildenafil. Patients should always speak to their doctor about any medicines they are taking, or any other treatments they may be using.
Disease Interaction
Alprostadilum may interact with certain diseases, such as heart disease, arterial disease, kidney disease, and liver disease. Patients should inform their doctor if they have any of these conditions prior to taking alprostadil.
Drug Interaction
Alprostadilum may interact with certain drugs, such as blood thinners, nitrates, and certain heart medications. Patients should always inform their doctor about any medications they are taking prior to taking alprostadil.
Food Interactions
Alprostadilum may interact with certain foods and beverages, such as alcohol, grapefruit, and certain herbs. Patients should always check with their doctor before consuming any of the aforementioned products while taking alprostadil.
Pregnancy Use
Alprostadilum has not been studied in pregnant women and should not be used during pregnancy.
Lactation Use
Alprostadilum has not been studied in breastfeeding women and should not be used while breastfeeding.
Acute Overdose
The symptoms of an acute overdose of alprostadil include severe pain, abnormal erections, and priapism. If an overdose is suspected, the patient should seek immediate medical attention.
Contraindication
Alprostadilum should not be used in patients who have a history of priapism or any other conditions mentioned in the patient's medical history.
Use Direction
Alprostadilum should be taken as directed by the doctor. It should not be used more than once a day, and the recommended dose should not be exceeded.
Storage Condition
Alprostadilum should be stored in a cool, dry place away from light and moisture. It should be stored at a temperature of room temperature or below.
Volume of Distribution
The volume of distribution of alprostadil is unknown.
Half Life
The half-life of alprostadil is approximately 1.5 hours.
Clearance
The clearance of alprostadil is unknown.
Here you find in details version of Alprostadilum
Some Frequently Asked Questions About Alprostadilum
What is Alprostadilum?
Alprostadilum is a prescription drug that is used to treat erectile dysfunction and can also be used to treat some forms of pulmonary hypertension. It is a synthetic version of prostaglandin E1, the same hormone that is naturally produced in the body.
How is Alprostadilum used to treat erectile dysfunction?
Alprostadilum is typically used in men to treat erectile dysfunction by directly increasing blood flow to the penis. It can be administered orally, topically, intraurethrally, or intracavernosal.
What are the side effects of Alprostadilum?
The most common side effects of Alprostadilum are penile pain, penile swelling, and injection site irritation. Other side effects may include discoloration of the penis, itching, and burning.
Is Alprostadilum safe to use?
Alprostadilum is generally safe to use, although it may cause some side effects. It is important to follow the doctor’s instructions when taking Alprostadilum and to check all potential side effects.
What is the dosage of Alprostadilum?
The dosage of Alprostadilum will depend on your individual needs and must be determined by your doctor. Typically, the dosage will range from 25 to 100mcg.
How long does Alprostadilum take to work?
The effects of Alprostadilum can be felt as quickly as 15 minutes after administration. However, the effects will vary depending on the individual and the dosage being used.
Is Alprostadilum available over the counter?
No, Alprostadilum is a prescription drug and is not available over the counter.
Can Alprostadilum be taken with other drugs?
It is important to consult your doctor before taking Alprostadilum with any other medication. Some medications can interact with Alprostadilum and cause dangerous side effects.
Does Alprostadilum stay in the body after it has been used?
Alprostadilum has a short half-life and is eliminated from the body fairly quickly.
What is the cost of Alprostadilum?
The cost of Alprostadilum will vary depending on the dosage and form of the drug that is used. Generally, the cost can range from $10 to $50 for a single dose.
Are there alternatives to Alprostadilum?
Yes, there are a number of alternatives to Alprostadilum, including other prescriptions drugs, natural remedies, and lifestyle changes.
Can Alprostadilum be used for other purposes?
Yes, Alprostadilum is sometimes used for other purposes, such as to treat some forms of pulmonary hypertension.
Can Alprostadilum cause an erection that is too long?
Yes, Alprostadilum can cause a prolonged erection, lasting more than 4 hours. If this occurs, you should consult your doctor immediately.
Does Alprostadilum work for everyone?
No, Alprostadilum may not be effective for everyone. It may not work for some individuals, or it may only work partially. It is important to discuss your individual needs with your doctor.
Can Alprostadilum be used with condoms?
Yes, it is safe to use Alprostadilum with condoms. However, some condoms may be damaged if Alprostadilum is used, so it is important to check the instructions carefully.
How long does Alprostadilum last for?
The effects of Alprostadilum can last from 30 minutes to several hours, depending on the individual and the dose.
Is Alprostadilum addictive?
No, Alprostadilum is not addictive.
What is the best way to take Alprostadilum?
The best way to take Alprostadilum depends on the individual and what form of Alprostadilum is being used. Your doctor will be able to advise the best way for you.
Is Alprostadilum effective in all cases of erectile dysfunction?
No, Alprostadilum may not be effective in all cases of erectile dysfunction. Your doctor will be able to advise the best treatment for your individual needs.
Can Alprostadilum be used by women?
No, Alprostadilum is not approved for use by women and should not be used by women.
Can Alprostadilum be used to treat premature ejaculation?
No, Alprostadilum is not approved to treat premature ejaculation and should not be used for this purpose.
What are the potential long-term risks of using Alprostadilum?
The long-term risks of using Alprostadilum are not yet known, as it is a relatively new drug. It is important to discuss potential risks with your doctor before using Alprostadilum.
Can Alprostadilum increase sperm count?
No, Alprostadilum is not known to increase sperm count.
Can Alprostadilum be used to treat other types of male sexual dysfunction?
No, Alprostadilum is not approved for use in treating other types of male sexual dysfunction.
Is Alprostadilum available in a generic form?
No, Alprostadilum is only available in brand-name form.
What is the dosage of Alprostadilum for pulmonary hypertension?
The dosage of Alprostadilum for treating pulmonary hypertension depends on the individual needs and must be determined by your doctor.
Does Alprostadilum work immediately?
The effects of Alprostadilum can be felt as quickly as 15 minutes after administration. However, the effects will vary depending on the individual and the dosage being used.
Can Alprostadilum be used with alcohol?
It is not recommended to use Alprostadilum with alcohol, as alcohol can increase the risk of side effects.
Can Alprostadilum cause psychological dependence?
No, Alprostadilum does not cause psychological dependence.
Can Alprostadilum be used with other forms of treatment for erectile dysfunction?
Yes, Alprostadilum can be used in combination with other forms of treatment for erectile dysfunction. However, it is important to consult your doctor before beginning any combination treatment.
Can Alprostadilum be used to treat female sexual dysfunction?
No, Alprostadilum is not approved for use in treating female sexual dysfunction.
Can Alprostadilum cause an allergic reaction?
Yes, Alprostadilum can cause an allergic reaction. If you experience any signs of an allergic reaction, such as hives or difficulty breathing, you should consult your doctor immediately.
Does Alprostadilum interact with any other medications?
It is important to consult your doctor before taking Alprostadilum with any other medication. Some medications can interact with Alprostadilum and cause dangerous side effects.
Can Alprostadilum increase fertility?
No, Alprostadilum does not increase fertility.
Can Alprostadilum be taken by diabetics?
Yes, Alprostadilum can be taken by diabetics. However, it is important to consult your doctor before taking Alprostadilum.
Can Alprostadilum be used while pregnant?
No, Alprostadilum is not approved for use in pregnant women and should not be used while pregnant.
What is the most common side effect of Alprostadilum?
The most common side effect of Alprostadilum is penile pain, penile swelling, and injection site irritation.
How do I dispose of Alprostadilum?
Alprostadilum should be disposed of according to local regulations. You should consult your local pharmacy or doctor for advice on how to safely dispose of Alprostadilum.
Does Alprostadilum interact with other drugs?
Yes, Alprostadilum can interact with other drugs. It is important to consult your doctor before taking Alprostadilum with any other medication.
Can Alprostadilum affect a man’s libido?
No, Alprostadilum is not known to affect a man’s libido.