Alpha-Diethylaminopropiophenone
Alpha-Diethylaminopropiophenone Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Alpha-Diethylaminopropiophenone is a brand name. Its generic name is Diethylpropion.
Introduction
Alpha-Diethylaminopropiophenone is a prescription weight loss drug used to help people lose weight by suppressing the appetite, increasing metabolism, and increasing energy levels to induce satiety. It is a member of the digestive enzyme inhibitor drug class, and is sometimes referred to as an anti-obesity medication. It is available as an oral tablet and an extended-release capsule.
Uses for
Alpha-Diethylaminopropiophenone is used in the treatment of obesity as a short-term adjunct therapy. It should be used in conjunction with a sensible diet and exercise plan. It is also used to suppress appetite and reduce cravings, and to help promote weight loss.
Mechanism of Action
Alpha-Diethylaminopropiophenone works by increasing the activity of norepinephrine, a neurotransmitter in the brain. This causes a decrease in appetite, thus leading to weight loss. It also acts as a stimulant, resulting in increased energy levels and metabolism.
How Long Does It Take to Work?
The effects of diethylpropion usually take 3-4 hours to be apparent, and are usually experienced within 24 hours.
Absorption
Alpha-Diethylaminopropiophenone is rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are usually reached within 4-5 hours of administration.
Route of Elimination
Alpha-Diethylaminopropiophenone is primarily eliminated renally via the kidneys as unchanged drug and metabolites.
Dosage
Alpha-Diethylaminopropiophenone is typically supplied as 75 mg tablets or extended-release capsules (ER-CAPs®) of ranging from 27.5 mg to 225 mg. The usual dose is 75 mg two to three times a day 15-30 minutes before meals. The extended-release capsules should be taken once daily, preferably in the morning. Treatment should not exceed 12 weeks.
Administration
Alpha-Diethylaminopropiophenone should be taken orally in the morning, usually 15-30 minutes before meals with a full glass of water. It can also be taken at bedtime if it causes nausea.
Side Effects
Common side effects of Alpha-Diethylaminopropiophenone include headache, dry mouth, insomnia, dizziness, constipation, and nausea. Other side effects such as chest pain, psychosis, and an increase in blood pressure have also been reported.
Toxicity
The acute toxicity of Alpha-Diethylaminopropiophenone is relatively low. In animals, doses of up to 1500 mg/kg have been reported to cause no fatalities. Overdoses of up to 400 mg have been reported in humans with no fatalities. Chronic toxicity is generally unknown and more clinical data is needed.
Precautions
Alpha-Diethylaminopropiophenone should be used with caution in patients with high blood pressure, heart disease, diabetes, hyperthyroid, glaucoma, anorexia nervosa, bulimia, kidney or liver disease, or those taking other stimulants such as amphetamines or MAO inhibitors. It should also be used with caution in elderly and pregnant patients.
Interactions
Alpha-Diethylaminopropiophenone may interact with a variety of medications, including antidepressants, hypertensives, diuretics, and antihistamines. It should not be taken with alcohol.
Disease Interaction
Alpha-Diethylaminopropiophenone is contraindicated in patients with the following conditions: hypertension, glaucoma, a history of drug abuse, and cardiovascular or cerebrovascular disease.
Drug Interaction
Alpha-Diethylaminopropiophenone may interact with a variety of medications, including antidepressants, hypertensives, diuretics, and antihistamines. It should not be taken with alcohol.
Food Interactions
Alpha-Diethylaminopropiophenone should be taken with food to be effective. Eating a meal before taking the drug will help reduce the risk of side effects.
Pregnancy Use
Alpha-Diethylaminopropiophenone is not recommended for use during pregnancy. It should not be used unless the potential benefits outweigh the potential risks to the fetus.
Lactation Use
Alpha-Diethylaminopropiophenone is excreted in breast milk and should not be used by nursing mothers.
Acute Overdose
An acute overdose of Alpha-Diethylaminopropiophenone can lead to dizziness, rapid heartbeat, restlessness, tremors, nausea, vomiting, anxiety, and confusion. If an overdose is suspected, the patient should seek medical attention.
Contraindication
Alpha-Diethylaminopropiophenone is contraindicated in patients with hypertension, glaucoma, a history of drug abuse, or cardiovascular or cerebrovascular disease.
Use Direction
Alpha-Diethylaminopropiophenone should be taken orally, usually 15-30 minutes before meals with a full glass of water. It is important to take the medication as prescribed by your doctor and not to exceed the recommended dose.
Storage Condition
Alpha-Diethylaminopropiophenone should be stored in a cool, dry place, away from direct sunlight and out of reach of children and pets. It should also be kept away from heat, moisture, and precipitation.
Volume of Distribution
The volume of distribution for Alpha-Diethylaminopropiophenone is not well established. It is believed to be less than 10 L/kg.
Half Life
The half-life of Alpha-Diethylaminopropiophenone is approximately 4-6 hours.
Clearance
The elimination half-life of Alpha-Diethylaminopropiophenone is approximately 1.5 hours. The renal clearance for this drug is approximately 4-7 L/hr/kg.
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