Ado-trastuzumab Emtansine

Ado-trastuzumab Emtansine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ado-trastuzumab Emtansine is a brand name. Its generic name is Trastuzumab.

What is Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine is a type of monoclonal antibody used to treat certain types of breast cancer. It is a tumor suppressor, meaning it helps to slow the growth and spread of tumor cells.

Uses of Ado-trastuzumab Emtansine

Ado-trastuzumab Emtansine is primarily used to treat HER2-positive metastatic breast cancer and HER2-overexpressing early-stage breast cancer. Ado-trastuzumab Emtansine is also indicated for the treatment of gastric cancer in combination with other medications. It may also be used in combination with other cancer treatments to reduce the risk of cancer recurrence.

Mechanism of Action

Ado-trastuzumab Emtansine works by binding to HER2 receptors on cancer cells. This blocks the growth and spread of the cancer cells, thus suppressing the growth of the tumor and slowing the progression of the disease.

How Long Does It Take to Work?

The effects of trastuzumab can start to be seen within 2-4 weeks after beginning treatment. It is important to follow up regularly with your doctor to ensure that your cancer is responding to the treatment.

Absorption, Route of Elimination and Dosage

Ado-trastuzumab Emtansine is administered intravenously. It is rapidly absorbed and its half-life is about 28 days. Dosing of trastuzumab varies and should be determined by a doctor. Usual dosing is 4mg/kg body weight for a single dose, followed by doses of 2mg/kg every three weeks until the desired response is achieved. Your doctor will usually start with a higher dose and then lower it if necessary.

Administration

Ado-trastuzumab Emtansine is administered intravenously with an infusion pump. It is important that the solution is not heated and is well mixed prior to administration.

Side Effects

The most common side effects of trastuzumab include fatigue, nausea, vomiting, diarrhea, constipation, skin rash, and infusion site reactions. Other rare but serious side effects include heart problems, lung problems, and allergic reactions. Talk to your doctor before beginning treatment with trastuzumab.

Toxicity, Precaution and Interaction

Ado-trastuzumab Emtansine has a low risk of toxicity. However, it is important to contact your doctor immediately if any signs of an allergic reaction are experienced, such as a rash, itching, or difficulty breathing. Ado-trastuzumab Emtansine may also interact with other medications, so it is important to let your doctor know about any other medications you are taking.

Disease Interactions and Drug Interactions

Ado-trastuzumab Emtansine can interact with some diseases, such as liver or kidney disease, and with some medications, such as aspirin, nonsteroidal anti-inflammatory drugs, and certain antibiotics. Talk to your doctor before beginning trastuzumab treatment if you have any concerns.

Food Interactions

Ado-trastuzumab Emtansine may interact with some foods, such as caffeine, alcohol, and certain vitamins and minerals. It is important to discuss any dietary restrictions or concerns with your doctor before beginning treatment.

Pregnancy Use and Lactation Use

Ado-trastuzumab Emtansine should not be used during pregnancy. Ado-trastuzumab Emtansine is excreted in breast milk, so it should be avoided during lactation. Women should also not breastfeed while taking trastuzumab.

Acute Overdose

An overdose of trastuzumab can cause serious side effects, such as anaphylaxis and oliguria. If an overdose is suspected, contact your doctor immediately.

Contraindication

Ado-trastuzumab Emtansine should not be used in people who are hypersensitive to it or any of its components. It is also contraindicated in people with prior exposure to any anti-HER2 therapies.

Use Direction, Storage Condition and Volume of Distribution

Ado-trastuzumab Emtansine should only be used under the direction of a doctor. It should be stored at room temperature and must not be frozen or heated. The volume of distribution of trastuzumab is not known.

Half Life and Clearance

The half-life of trastuzumab is about 28 days and its clearance is not known.

Here you find in details version of Ado-trastuzumab Emtansine

Some Frequently Asked Questions About Ado-trastuzumab Emtansine

1. What is Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine is a cancer treatment drug, an antibody used to treat certain types of advanced breast cancer. It is a recombinant DNA-derived humanized monoclonal antibody that binds to HER2 on cancer cells and halts their growth and spread.

2.How effective is Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine has been found to be very effective in advanced breast cancer when used in combination with chemotherapy, and is estimated to improve overall response rate and progression-free survival by nearly 50%.

3. What type of cancer is treated with Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine is used to treat breast cancer that is HER2-positive, meaning that it contains too many HER2 receptors that promote the growth and spread of the cancer cells.

4. How is Ado-trastuzumab Emtansine administered?

Ado-trastuzumab Emtansine is administered intravenously by a healthcare professional in a hospital or clinic.

5. How long does Ado-trastuzumab Emtansine treatment last?

Ado-trastuzumab Emtansine treatment can last anywhere from a few weeks to several months, depending on the severity of the cancer and how well the individual responds to the treatment.

6. What side effects does Ado-trastuzumab Emtansine cause?

Ado-trastuzumab Emtansine can cause a variety of side effects including fever, chills, fatigue, nausea and vomiting, headache, rash, joint pain, and low white blood cell count.

7. What is the cost of Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine can cost anywhere from $35,000 to $50,000 per year.

8. Is Ado-trastuzumab Emtansine safe to use?

Ado-trastuzumab Emtansine has been found to be generally safe when administered correctly and monitored by a healthcare professional.

9. Is Ado-trastuzumab Emtansine available worldwide?

Ado-trastuzumab Emtansine is available in many countries around the world.

10. Is Ado-trastuzumab Emtansine FDA approved?

Ado-trastuzumab Emtansine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced breast cancer.

11. How often is Ado-trastuzumab Emtansine given?

Ado-trastuzumab Emtansine is typically given once every 3 weeks in combination with chemotherapy.

12. Who should not use Ado-trastuzumab Emtansine?

Ado-trastuzumab Emtansine is not recommended for those with an allergy to the drug or in individuals with healthy kidneys or liver, as it can cause kidney or liver damage. It should not be used in pregnant women, as it can cause harm to an unborn baby. Additionally, it is not recommended for individuals with a weakened immune system.

13. Is Ado-trastuzumab Emtansine the same as Herceptin?

Yes, Ado-trastuzumab Emtansine and Herceptin are the same drug.

14. Can Ado-trastuzumab Emtansine cause hair loss?

Ado-trastuzumab Emtansine can potentially cause hair loss as a side effect, but it is usually reversible.

15. Are there any clinical trials for Ado-trastuzumab Emtansine?

Yes, currently there are over 100 clinical trials for Ado-trastuzumab Emtansine.

16. How long does it take for Ado-trastuzumab Emtansine to start working?

Ado-trastuzumab Emtansine usually starts working within several weeks of administration, but it can take a few months for it to reach its peak effectiveness.

17. Is there an alternative to Ado-trastuzumab Emtansine?

The alternative to Ado-trastuzumab Emtansine is Lapatinib, which is a HER2 inhibitor drug.

18. Is Ado-trastuzumab Emtansine safe for children?

Ado-trastuzumab Emtansine is not recommended for use in children.

19. What type of cancer is Ado-trastuzumab Emtansine used for?

Ado-trastuzumab Emtansine is used to treat HER2-positive breast cancer.

20. Is Ado-trastuzumab Emtansine a chemotherapy drug?

No, Ado-trastuzumab Emtansine is an antibody drug used in combination with chemotherapy to treat breast cancer.

21. Does Ado-trastuzumab Emtansine have any long-term effects?

Yes, there have been reports of long-term effects such as heart failure, osteoporosis, and increased risk of infection in those who have used Ado-trastuzumab Emtansine.

22. Can Ado-trastuzumab Emtansine cure cancer?

No, Ado-trastuzumab Emtansine cannot cure cancer, but it can help reduce the amount of cancer cells in the body and help improve symptoms.

23. Is Ado-trastuzumab Emtansine covered by insurance?

The coverage of Ado-trastuzumab Emtansine depends on your insurance provider and policy.

24. How long does Ado-trastuzumab Emtansine stay in the body?

Ado-trastuzumab Emtansine is cleared from the body within a few days of administration.

25. Is Ado-trastuzumab Emtansine given intravenously or orally?

Ado-trastuzumab Emtansine is given intravenously.

26. Can Ado-trastuzumab Emtansine be used with other cancer treatments?

Yes, Ado-trastuzumab Emtansine can be used in combination with other cancer treatments, such as chemotherapy.

27. Is Ado-trastuzumab Emtansine only used for breast cancer?

Yes, Ado-trastuzumab Emtansine is only used to treat HER2-positive breast cancer.

28. Is Ado-trastuzumab Emtansine used for early or late-stage breast cancer?

Ado-trastuzumab Emtansine is typically used in late-stage breast cancer, when the cancer has spread beyond the breast.

29. Are there any gender restrictions for taking Ado-trastuzumab Emtansine?

No, Ado-trastuzumab Emtansine can be used in both men and women.

30. Can Ado-trastuzumab Emtansine be used in combination with other drugs?

Yes, Ado-trastuzumab Emtansine can be used in combination with other drugs, such as chemotherapy.