Acidum Gadobenicum
Acidum Gadobenicum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Acidum Gadobenicum is a brand name. Its generic name is Gadobenic acid.
Gadobenic Acid
Acidum Gadobenicum is a pharmaceutical compound used to treat various medical conditions, particularly autoimmune disorders. It works by inhibiting an enzyme known as inosine-specific phosphofructokinase-2 (ISPF-2). This enzyme is responsible for converting uridine-diphosphate (UDP)-glucose to UDP-N-acetylglucosamine. By interfering in this pathway, gadobenic acid helps to reduce the symptoms of various autoimmune conditions.
Uses
Acidum Gadobenicum is used to treat autoimmune disorders, such as rheumatoid arthritis, lupus, inflammatory bowel disease, and psoriatic arthritis. It is also used to treat some cases of Crohn’s disease, ulcerative colitis, and sarcoidosis.
Mechanism of Action
Acidum Gadobenicum works by inhibiting the enzyme, ISPF-2, which helps to regulate inflammation in the body. By blocking this enzyme, gadobenic acid helps to reduce inflammation in the body, which in turn helps to reduce the symptoms of various autoimmune conditions.
How Long Does It Take to Work?
Acidum Gadobenicum typically takes several days or weeks to fully take effect. Most patients will start to feel some relief within a few days of starting treatment, but it may take weeks for it to reach its full potential.
Absorption
Acidum Gadobenicum is rapidly absorbed into the bloodstream when taken orally. It has a high bioavailability and is extensively metabolized in the liver.
Route of Elimination
Acidum Gadobenicum is mostly eliminated through the kidneys in the form of metabolites. Small amounts may also be excreted in the urine and feces.
Dosage
Acidum Gadobenicum is available in tablet or capsule form in doses of 10 mg, 20 mg, and 40 mg. The recommended dose is 10 mg twice daily, taken after meals. For patients with kidney impairment, the dose should not exceed 20 mg per day.
Administration
Acidum Gadobenicum should be taken orally with a full glass of water. It should be taken after meals for maximal absorption.
Side Effects
Common side effects of gadobenic acid include headache, nausea, stomach pain, diarrhea, and fatigue. Other serious side effects may include liver failure, allergic reactions, and anemia.
Toxicity
Overdoses of gadobenic acid can be fatal, with symptoms including rapid breathing, seizures, vomiting, and coma. If an overdose is suspected, seek medical attention immediately.
Precautions and Interactions
Acidum Gadobenicum should not be taken with any other drugs without consulting a doctor or pharmacist. It can interact with some medications, including some antibiotics and antifungals. It should also be avoided in patients with kidney or liver problems, as it can be toxic in high doses.
Disease Interactions
Acidum Gadobenicum should be avoided in patients with severe anemia or any other disease that may reduce blood cell counts. It can also interact with some autoimmune conditions, so patients should discuss any possible interactions with their doctor.
Drug Interactions
Acidum Gadobenicum can interact with certain medications, such as antibiotics, antifungals, and some other drugs. Patients should discuss any possible interactions with their doctor before taking this medication.
Food Interactions
Acidum Gadobenicum should be taken with food to maximize absorption. It should not be taken with grapefruit juice or dairy products, as these can affect the absorption of the medication.
Pregnancy Use
Acidum Gadobenicum should not be taken during pregnancy unless absolutely necessary. It has been classified as Pregnancy Category C, meaning that it could cause harm to an unborn baby if taken during pregnancy.
Lactation Use
Acidum Gadobenicum should not be taken while breastfeeding unless absolutely necessary. It can be passed to the baby through breast milk, so caution should be taken when using it while breastfeeding.
Acute Overdose
Acidum Gadobenicum can be toxic in high doses. Symptoms of an overdose can include rapid breathing, seizures, vomiting, and coma. If an overdose is suspected, seek medical attention immediately.
Contraindication
Acidum Gadobenicum should not be taken by patients with severe anemia or any other disease that may reduce white blood cell counts. It should also be avoided in patients with active infections or kidney or liver problems.
Use Directions
Acidum Gadobenicum should be taken orally with a full glass of water. It should be taken after meals for maximal absorption. The recommended dose is 10 mg twice daily.
Storage Condition
Acidum Gadobenicum should be stored at room temperature away from light and moisture. It should be kept out of the reach of children and pets.
Volume of Distribution
Acidum Gadobenicum has a volume of distribution of about 10.9L after a single oral dose.
Half Life
Acidum Gadobenicum has a half-life of about 4.3 hours after a single oral dose.
Clearance
Acidum Gadobenicum has a clearance rate of about 5.71 mL/min after a single oral dose.
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