Cortibiotan
Cortibiotan Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Cortibiotan is a brand name. Its generic name is Prednisolone + sulfacetamide.
Introduction
Prednisolone and Sulfacetamide are two synthetic drugs that together act as an anti-inflammatory and antibiotic combination medication. It is used to treat various types of inflammatory eye conditions, such as iritis and keratitis. It is also prescribed off label for various other uses including skin infections, chronic urticaria, and alopecia areata, an autoimmune disorder characterized by round patches of hair loss.
Uses
The combination of prednisolone and sulfacetamide is used to treat a variety of medical conditions, including:
- Inflammatory eye diseases such as iritis and keratitis
- Neuro-inflammatory diseases such as optic neuritis and multiple sclerosis
- Allergies and hay fever
- Skin infections
- Chronic urticaria
- Alopecia areata
Mechanism of Action
The mechanism of action of prednisolone and sulfacetamide is twofold. Prednisolone is a synthetic corticosteroid that blocks the inflammation process by reducing the activity of the immune system. Sulfacetamide, an anti-bacterial agent, acts by inhibiting the growth of bacteria, thereby reducing the inflammation. The combined action of both drugs results in a reduction in the symptoms associated with the conditions mentioned above.
How Long Does it Take to Work?
It typically takes a few days for the combination of prednisolone and sulfacetamide to start working. Depending on the severity of the condition, it can take up to a few weeks for the drugs to have a significant effect on the symptoms.
Absorption
The combination of prednisolone and sulfacetamide is rapidly absorbed from the gastrointestinal tract after oral administration. After absorption, the drugs are distributed to the target organs, including the eyes, brain, and skin.
Route of Elimination
Prednisolone and sulfacetamide are eliminated mostly via the kidneys. Some of the drugs are also metabolized and eliminated via the liver.
Dosage
The dosage and the duration of treatment depend on the type and severity of the condition being treated. Prednisolone is usually administered orally at a dose of 2-50 mg per day. Sulfacetamide is usually administered topically at a concentration of 10-50%.
Administration
The combination of prednisolone and sulfacetamide is usually administered orally or topically depending on the condition being treated. Oral administration is typically done daily or as directed by a physician. Topical administration is usually twice daily.
Side Effects
The most common side effects of prednisolone and sulfacetamide include: nausea, vomiting, dizziness, headache, upset stomach, abdominal pain, diarrhea, and rash. If any of these side effects worsen or persist, contact a healthcare professional right away.
Toxicity
The toxicity of prednisolone and sulfacetamide is relatively low. High dosages are generally not associated with significant toxicity.
Precaution
Before using this medication, tell your doctor or pharmacist: if you are pregnant, planning to become pregnant, or are breastfeeding; if you are taking any other medications; and if you have any allergies or asthma. Also, inform your doctor or pharmacist if you have any other medical conditions or are planning a surgery.
Interactions
Drug interactions may occur with prednisolone and sulfacetamide. Be sure to inform your doctor or pharmacist about all the drugs you are taking, including prescription, non-prescription, and herbal medications.
Disease Interactions
In some cases, prednisolone and sulfacetamide may interact with certain medical conditions. Before using this medication, inform your doctor if you have any of the following medical conditions: liver or kidney problems, diabetes, glaucoma, or osteoporosis.
Drug Interactions
Drug interactions may occur with prednisolone and sulfacetamide. Be sure to inform your doctor or pharmacist about all the drugs you are taking, including prescription, non-prescription, and herbal medications.
Food Interactions
Food interactions may occur with prednisolone and sulfacetamide. Be sure to tell your doctor or pharmacist about any foods you are eating that may interact with this medication.
Pregnancy Use
This medication has not been studied for its use during pregnancy. Therefore, it is not recommended for use during pregnancy, unless it is absolutely necessary. If you are pregnant or planning to become pregnant, be sure to inform your doctor before starting this medication.
Lactation Use
This medication has not been studied for its use during lactation. Therefore, it is not recommended for use during lactation, unless it is absolutely necessary. If you are breastfeeding or planning to breastfeed, be sure to inform your doctor before starting this medication.
Acute Overdose
Large doses of prednisolone and sulfacetamide may cause serious harm. If an overdose is suspected, contact your local poison control center or emergency medical service right away.
Contraindication
This medication should not be used by people who are allergic to any of its ingredients. It should also not be used by people who have tuberculosis, herpes infection of the eye, fungal infections, or any other type of infection. In addition, this medication should not be used by people with kidney and liver disease.
Use Direction
The combination of prednisolone and sulfacetamide should be taken as directed by a healthcare professional. Be sure to read and follow the instructions on the label. Do not take more or less than what is prescribed.
Storage Condition
This medication should be stored in a cool, dry place away from direct sunlight or heat. Keep the medication out of the reach of children and pets.
Volume of Distribution
The volume of distribution of prednisolone and sulfacetamide is estimated to be approximately 21.5 L/kg.
Half Life
The elimination half-life of prednisolone and sulfacetamide is estimated to be approximately 16 hours.
Clearance
The clearance of prednisolone and sulfacetamide is estimated to be approximately 2.1 L/h/kg.
Here you find in details version of Cortibiotan