13-cis-retinoic Acid

13-cis-retinoic Acid Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? 13-cis-retinoic Acid is a brand name. Its generic name is Isotretinoin.

13-cis-retinoic Acid Introduction

13-cis-retinoic Acid (INN, ) (earlier known as Accutane, Roaccutane, Claravis, Amnesteem, Decutan, Isotane, Sotret and Oratane) is a prescription-only medication and is an extremely effective treatment for severe acne. It is a drug derived from Vitamin A and belongs to a class of drugs called retinoids.

Uses For

13-cis-retinoic Acid is used to treat severe types of acne such as nodular or cystic acne which has not responded to other treatments. It can also be used to treat a range of other skin conditions including the signs of sun damage, age spots and other pigmentation disorders.

Mechanism of Action

The exact mechanism of action is not known, but it is thought to work by reducing levels of oils in the skin. This helps to reduce inflammation and prevent the formation of new acne lesions. It also helps to reduce the size of existing lesions and improve skin tone.

How Long Does It Take to Work?

13-cis-retinoic Acid usually begins to work within 1-2 weeks, but it can take a few months to achieve the full benefit of the medication. It is important that patients follow their doctor's instructions in order to get the most out of the medication.

Absorption

13-cis-retinoic Acid is rapidly and completely absorbed in the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration. The absorption is not affected by food.

Route of Elimination

13-cis-retinoic Acid is eliminated from the body primarily by the liver. It is also eliminated through the bile and kidneys.

Dosage

13-cis-retinoic Acid is available in capsules of 10mg, 20mg and 40mg. The recommended starting dose is 0.5-1mg/kg per day for the first four months and should be adjusted according to response. For most patients, the initial dose of 20mg per day is usually sufficient however some might require higher doses. It is important that the dosage is adjusted according to patient response and monitored by your doctor.

Administration

13-cis-retinoic Acid is taken as a single daily dose with or without food. It is important to take the medication at the same time every day to achieve it's full therapeutic effect.

Side Effect

Common side effects of 13-cis-retinoic Acid include: dryness of the skin and mucous membranes, muscle and joint pain, hair loss, elevated liver enzyme levels, itching, rash, and nose bleeds. Serious side effects include depression, psychosis, and increased risk of birth defects.

Toxicity

13-cis-retinoic Acid is considered to be a relatively safe drug but can be toxic in high doses or if taken for long periods of time. It is important to follow the doctor's instructions when taking this medication in order to minimize potential risks.

Precaution

Before taking isotretinoin, patients should consult their doctor about any medical conditions they may have. Women who are pregnant or planning on becoming pregnant should avoid taking isotretinoin as it can cause birth defects. 13-cis-retinoic Acid can cause vision problems, so special precautions may be necessary when driving or operating machinery.

Interaction

13-cis-retinoic Acid can interact with other medications such as antibiotics, antifungal drugs, vitamin A, St. John's wort and birth control pills. Patients should consult their doctor before taking any other medications while on isotretinoin.

Disease Interaction

13-cis-retinoic Acid can interact with other medical conditions such as diabetes, asthma, or depression. Patients should inform their doctor of any existing medical conditions before taking isotretinoin.

Drug Interaction

13-cis-retinoic Acid can interact with other drugs such as birth control pills, antibiotics, antifungal drugs, vitamin A, and St. John's wort. It is important to inform your doctor of any other drugs you are taking before taking isotretinoin.

Food Interactions

13-cis-retinoic Acid can interact with certain foods such as dairy products, kefir, citrus, and chili peppers which may increase the risk of side effects such as dryness and irritation. Patients should avoid these foods when taking isotretinoin.

Pregnancy Use

13-cis-retinoic Acid should not be used by pregnant women as it can cause birth defects. Women who are planning to become pregnant should avoid taking this medication.

Lactationuse

13-cis-retinoic Acid is not recommended for nursing mothers due to the risk of side effects in the infant. Women who are breastfeeding should avoid taking this medication.

Acute Overdose

In case of an acute overdose, the patient should seek medical attention right away. Signs and symptoms of overdose may include severe abdominal pain, vomiting, diarrhea, and low blood pressure.

Contraindication

13-cis-retinoic Acid is contraindicated in people who are sensitive to it or its ingredients, or who have any other allergy. It is also contraindicated in pregnant women, nursing mothers, or people with severe liver disease.

Use Direction

It is important to follow the doctor’s instructions for taking isotretinoin. The tablets should be taken as a single daily dose with or without food. It is important to take the medication at the same time each day for the best effect.

Storage Condition

13-cis-retinoic Acid capsules should be stored in a cool, dry place away from direct sunlight. It is important to keep the capsules in their original container, tightly closed and out of reach of children.

Volume of Distribution

The volume of distribution of isotretinoin is approximately 1-2 L/kg.

Half Life

The half-life of isotretinoin is approximately 21 hours.

Clearance

The total body clearance of isotretinoin is approximately 1.1L/hour per kg.

Here you find in details version of 13-cis-retinoic Acid

Some Frequently Asked Questions About 13-cis-retinoic Acid

What is 13-cis-retinoic Acid?

13-cis-retinoic Acid is a prescription medication used to treat severe acne. It is a powerful medication that works by reducing the amount of facial oil released by the body.

Is 13-cis-retinoic Acid dangerous?

13-cis-retinoic Acid is a safe and effective medication when taken as prescribed by a doctor. It can cause serious side effects if not taken correctly.

What are the side effects of 13-cis-retinoic Acid?

The most common side effects of 13-cis-retinoic Acid include dry skin, chapped lips, nosebleeds, muscle aches, and changes in mood. It can also cause birth defects if taken by pregnant women.

Should 13-cis-retinoic Acid be taken with food?

Your doctor will advise you on whether or not to take 13-cis-retinoic Acid with food. It is important to take it as prescribed in order to reduce the risk of adverse effects.

How long does it take for 13-cis-retinoic Acid to work?

Most people begin to see improvement of their acne symptoms within 2-3 months of taking 13-cis-retinoic Acid. However, it can take up to 6 months for the full effects to be seen.

What are the long-term effects of 13-cis-retinoic Acid?

There are no established long-term side effects associated with 13-cis-retinoic Acid. However, it is important to speak to your doctor regularly to monitor any new symptoms.

What conditions is 13-cis-retinoic Acid used to treat?

13-cis-retinoic Acid is primarily used to treat severe forms of acne, such as nodular or cystic acne. It may also be used to treat other skin conditions such as rosacea.

Can 13-cis-retinoic Acid be taken with other medications?

It is important to talk to your doctor before taking any other medications while taking 13-cis-retinoic Acid. Some medications may interact with 13-cis-retinoic Acid and cause serious side effects.

Will 13-cis-retinoic Acid cause weight gain?

13-cis-retinoic Acid is not known to cause weight gain. However, it can cause changes in mood, and some people may experience an increase in appetite.

Do I need to use sunscreen while taking 13-cis-retinoic Acid?

Yes, it is important to use sunscreen and avoid prolonged sun exposure while taking 13-cis-retinoic Acid. Radiation exposure can increase your risk of side effects.

Are there any foods I should avoid while taking 13-cis-retinoic Acid?

There are no specific foods to avoid while taking 13-cis-retinoic Acid, however it is recommended to maintain a healthy balanced diet. Certain foods such as alcohol and caffeine can aggravate side effects.

Should I take 13-cis-retinoic Acid before or after meals?

Your doctor will advise you on whether to take 13-cis-retinoic Acid before or after meals. It is important to take it as prescribed in order to reduce the risk of adverse effects.

What if I forget to take my 13-cis-retinoic Acid dose?

If you forget to take your regular dose of 13-cis-retinoic Acid, take it as soon as you remember. However, if it is almost time for the next dose, do not double up and take two doses at once.

What if I take too much 13-cis-retinoic Acid?

It is important not to take more than the recommended dose of 13-cis-retinoic Acid. If you think you have taken too much, contact your doctor or pharmacist immediately.

Can I use 13-cis-retinoic Acid while breastfeeding?

It is not advised to take 13-cis-retinoic Acid while breastfeeding. 13-cis-retinoic Acid can pass into the breast milk and could have adverse effects on the baby.

Does 13-cis-retinoic Acid cause depression?

Treatment with 13-cis-retinoic Acid can cause mood changes, and reports of depression have been associated with its use. It is important to speak to your doctor if you experience any negative mental health symptoms.

What is the recommended dosage of 13-cis-retinoic Acid?

The recommended dosage of 13-cis-retinoic Acid varies depending on individual circumstances. Your doctor will advise on the most suitable dose for you.

Can I donate blood while taking 13-cis-retinoic Acid?

It is not advised to donate blood while taking 13-cis-retinoic Acid, as it contains active ingredients that could be harmful to a recipient.

Can I drink alcohol while taking 13-cis-retinoic Acid?

It is not advised to drink alcohol while taking 13-cis-retinoic Acid. Alcohol can worsen side effects or make them more frequent.

What is the most common side effect of 13-cis-retinoic Acid?

The most common side effects of 13-cis-retinoic Acid are dry skin, chapped lips, nosebleeds, muscle aches, and changes in mood.

Can 13-cis-retinoic Acid be used to treat wrinkles?

13-cis-retinoic Acid is not approved to treat wrinkles, and its use is not recommended for this purpose.

Is it safe to exercise while taking 13-cis-retinoic Acid?

It is generally safe to exercise while taking 13-cis-retinoic Acid, however it is important to speak to your doctor before starting any new exercise routine.

Is 13-cis-retinoic Acid available over the counter?

No, 13-cis-retinoic Acid is a prescription medication and is not available over-the-counter.

What if I get pregnant while taking 13-cis-retinoic Acid?

It is important to stop taking 13-cis-retinoic Acid immediately if you think you may be pregnant. 13-cis-retinoic Acid can cause birth defects and should not be taken by pregnant women.

Will 13-cis-retinoic Acid make my acne worse before it gets better?

It is not uncommon to experience an initial worsening of acne before improvement is seen. This is known as the ‘purge period’ and is usually mild and temporary.

Can 13-cis-retinoic Acid help with blackheads?

Yes, 13-cis-retinoic Acid is effective at clearing blackheads. Its powerful anti-acne effects help reduce oil production, decrease inflammation, and unclog pores.

Is 13-cis-retinoic Acid recommended for teenage acne?

13-cis-retinoic Acid can be an effective treatment for teenage acne, however it is important to discuss the risks and benefits with your doctor before taking 13-cis-retinoic Acid.

How is 13-cis-retinoic Acid taken?

13-cis-retinoic Acid is taken in the form of capsules or tablets. It is usually taken twice daily with food or milk, and should be taken at the same time each day.

At what age can 13-cis-retinoic Acid be used?

13-cis-retinoic Acid is approved to treat acne in people aged 12 years and older. It is not recommended for use in children younger than 12.

Will 13-cis-retinoic Acid change my skin colour?

13-cis-retinoic Acid does not usually cause skin discoloration, however it is important to speak to your doctor if you experience any changes in skin colour.

Does 13-cis-retinoic Acid cause hair loss?

Hair loss is an uncommon side effect of isotretinoin treatment. If experienced, it is usually temporary and resolves once the treatment is completed.

Is it possible to overdose on 13-cis-retinoic Acid?

It is possible to overdose on 13-cis-retinoic Acid, however this is uncommon. If you think you have taken too much, contact your doctor or pharmacist immediately.

Does 13-cis-retinoic Acid have any long-term health risks?

There are no confirmed long-term health risks associated with 13-cis-retinoic Acid. However, it is important to speak to your doctor regularly to monitor any new symptoms.

How do I store my 13-cis-retinoic Acid medication?

13-cis-retinoic Acid should be stored at room temperature away from direct sunlight. It should also be kept out of reach of children and pets.

What should I do if I experience side effects from 13-cis-retinoic Acid?

If you experience any side effects from 13-cis-retinoic Acid, it is important to speak to your doctor immediately. Your doctor may suggest altering your dose or changing your medication.

How much does 13-cis-retinoic Acid cost?

The cost of 13-cis-retinoic Acid depends on your insurance provider. It is important to contact your insurance provider before ordering your medication.

Will I need to have regular blood tests while taking 13-cis-retinoic Acid?

It is recommended to have regular blood tests while taking 13-cis-retinoic Acid. This helps to ensure the medication is effective and safely monitored.

Is 13-cis-retinoic Acid safe to take during the summer months?

13-cis-retinoic Acid can be taken in the summer months, however it is important to use sun protection, wear light clothing, and avoid prolonged sun exposure.

Can I still wear makeup while taking 13-cis-retinoic Acid?

Yes, it is safe to wear makeup while taking 13-cis-retinoic Acid. However, it is important to choose non-comedogenic products to reduce the risk of blocked pores.

What are the differences between 13-cis-retinoic Acid and Accutane?

13-cis-retinoic Acid and Accutane are the same medication. Accutane is the brand name of 13-cis-retinoic Acid.